Katherine V. Houser

Multicounty Outbreak of Salmonella Agbeni Linked to Ice in a Cooler at a County Fair — Illinois, August 2024

Katherine V. Houser

On August 5, 2024, the Brown County (Illinois) Health Department (BCHD) was informed by the county sheriff that numerous potential jurors being screened for an upcoming trial had reported recently experiencing a gastrointestinal illness. One week later, on August 12, a laboratory-confirmed …

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Safety and pharmacokinetics of N6LS, a broadly neutralising monoclonal antibody for HIV: a phase 1, open-label, dose-escalation study in healthy adults

Richard L Wu, Katherine V. Houser, Martin R. Gaudinski, Alicia T. Widge et autres

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Early influenza virus exposure shapes the B cell response to influenza vaccination in individuals 50 years later

Abby Spangler, Geoffrey D. Shimberg, Grace Mantus, Lauren Y. Cominsky et autres

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Phase 1 dose-escalation trial evaluating a group 2 influenza hemagglutinin stabilized stem nanoparticle vaccine

Joseph P. Casazza, Amelia R. Hofstetter, Pamela Costner, LaSonji A Holman et autres

The relative conservation of the influenza hemagglutinin (HA) stem compared to that of the immunodominant HA head makes the HA stem an attractive target for broadly protective influenza vaccines. Here we report the first-in-human, dose-escalation, open-label trial (NCT04579250) evaluating an unadjuvanted group …

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Immune memory shapes human polyclonal antibody responses to H2N2 vaccination

Yuhe R. Yang, Julianna Han, Hailee R. Perrett, Sara T. Richey et autres

Influenza A virus subtype H2N2, which caused the 1957 influenza pandemic, remains a global threat. A recent phase 1 clinical trial investigating a ferritin nanoparticle vaccine displaying H2 hemagglutinin (HA) in H2-naive and H2-exposed adults enabled us to perform comprehensive structural and …

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Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials

Myra Happe, Amelia R. Hofstetter, Jing Wang, Galina V. Yamshchikov et autres

Ebola virus disease (EVD) is a filoviral infection caused by virus species of the Ebolavirus genus including Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV). We investigated the safety and immunogenicity of a heterologous prime-boost regimen involving a chimpanzee adenovirus 3 vectored Ebola …

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Immune memory shapes human polyclonal antibody responses to H2N2 vaccination

Yuhe R. Yang, Julianna Han, Hailee R. Perrett, Sara T. Richey et autres

Summary Influenza A virus subtype H2N2, which caused the 1957 influenza pandemic, remains a global threat. A recent phase I clinical trial investigating a ferritin nanoparticle displaying H2 hemagglutinin in H2-naïve and H2-exposed adults. Therefore, we could perform comprehensive structural and biochemical …

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Safety, tolerability, and immunogenicity of the Ebola Sudan chimpanzee adenovirus vector vaccine (cAd3-EBO S) in healthy Ugandan adults: a phase 1, open-label, dose-escalation clinical trial

Betty Mwesigwa, Katherine V. Houser, Amelia R. Hofstetter, Ana M. Ortega‐Villa et autres

Ouganda, us (code pays fourni par la source)

An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans

Sarah F. Andrews, Lauren Y. Cominsky, Geoffrey D. Shimberg, Rebecca A. Gillespie et autres

Current yearly seasonal influenza vaccines primarily induce an antibody response directed against the immunodominant but continually diversifying hemagglutinin (HA) head region. These antibody responses provide protection against the vaccinating strain but little cross-protection against other influenza strains or subtypes. To focus the …

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An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults

Alicia T. Widge, Amelia R. Hofstetter, Katherine V. Houser, Seemal F. Awan et autres

Influenza vaccines could be improved by platforms inducing cross-reactive immunity. Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines impedes induction of cross-reactive neutralizing stem-directed antibodies. A vaccine without the variable HA head domain has the potential to focus the …

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Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial

Melinda Hamer, Katherine V. Houser, Amelia R. Hofstetter, Ana M. Ortega‐Villa et autres

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List Of Contributors

Roshini S. Abraham, Behdad Afzali, Ana Águeda, Cem Akin et autres