Verena Lang

Abstract B044: Targeting the “undruggable” oncogene CCNE1 using a molecular glue degrader in CCNE1 amplified cancers

William Tahaney, Yimao Liu, Ahmed Abdullah, Vittoria Massafra et autres

Abstract Using our QuEENTM molecular glue degrader (MGD) discovery engine that integrates biochemical and cellular assays with in silico modeling, we identified and optimized MGDs that induce proteasomal degradation of cyclin E1 (CCNE1) as a therapeutic strategy for CCNE1-amplified cancers. We generated …

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Abstract PR003: Targeting the “undruggable” oncogene CCNE1 using a molecular glue degrader in CCNE1 amplified cancers

William Tahaney, Yimao Liu, Ahmed Abdullah, Vittoria Massafra et autres

Abstract Using our QuEENTM molecular glue degrader (MGD) discovery engine that integrates biochemical and cellular assays with in silico modeling, we identified and optimized MGDs that induce proteasomal degradation of cyclin E1 (CCNE1) as a therapeutic strategy for CCNE1-amplified cancers. We generated …

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Abstract 6778: Selective targeting of CCNE1 using molecular glue degraders for the treatment of CCNE1 amplified cancers

William M. Tahaney, Yimao Liu, Ahmed Abdullah, Vittoria Massafra et autres

Abstract Cyclin E1 (CCNE1) is a critical driver of cell cycle progression and cell proliferation. It acts as the regulatory subunit for the CCNE1-CDK2 holoenzyme, which coordinates cell cycle progression through the G1/S phases and effectively drives cell proliferation via RB phosphorylation …

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Trend analysis of methane uptake in 13 forest soils based on up to 24 years of field measurements in south-west Germany

Verena Lang, Valentin Gartiser, Peter Hartmann, Martin Maier

Methane (CH₄) plays a crucial role in global climate dynamics as a potent greenhouse gas. Forest soils are the most important terrestrial CH 4 -sinks, yet long-term trends in CH 4 -uptake remain underexplored, due to the lack of long-term field measurements …

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The Cancer/Testis Antigen FATE1 Antagonizes Fission and Preserves Mitochondrial Network Integrity under Cytotoxic Stress

Verena Lang, Jessica Zahn, Deepti Pai Tonse, Nathan Brady et autres

ABSTRACT FATE1 (Fetal and Adult Testis Expressed 1), also known as BJ-HCC-2, is a cancer-testis antigen with highly restricted expression in normal tissues but aberrant activation in diverse tumor types, where it localizes to both the outer mitochondrial membrane and the endoplasmic …

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ConFluxPro: A toolkit for soil gas analysis

Valentin Gartiser, Verena Lang, Martin Maier

ConFluxPro is an R-package to model soil gas fluxes with the flux-gradient method (FGM).The FGM is a cost-effective way to measure fluxes and production rates of gases in soils (Maier & Schack-Kirchner, 2014).It relies on the principle that gas exchange in soils …

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A New Approach to Address Soil Heterogeneity as a Source of Uncertainty in the Flux‐Gradient Method: CO 2 Case Studies

Valentin Gartiser, Verena Lang, Martin Maier

ABSTRACT The flux‐gradient method (FGM) is an important tool to study soil‐atmosphere and subsurface gas fluxes. The simplicity of the approach can lead to an uncritical application. Typical uncertainty found in the input parameters is not considered in most cases. Their potential …

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Management von Produktinnovationen in der deutschen Industrie vor einer erwarteten Rezession

Verena Lang, Esther Bollhöfer

Liming leads to changes in the physical properties of acidified forest soils

Peter Hartmann, Lelde Jansone, Lucas Mahlau, Martin Maier et autres

Abstract Background Forest liming is a common practice in many German forests, which aims primarily at improving soil chemical properties that have been negatively impacted by acid rain. Effects on physical functions have not yet been studied widely. Aims The hypothesis of …

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Spotting ethylene in forest soils—What influences the occurrence of the phytohormone?

Verena Lang, Veronika Schneider, Heike Puhlmann, Alexander Schengel et autres

Abstract Due to the rapid microbial degradation, ethylene (ethene; C 2 H 4 ) detection in most soils is difficult. The knowledge about factors favoring the occurrence of C 2 H 4 is mainly based on laboratory experiments which are not necessarily …

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Methanotrophic bacteria in forest soils – should I stay or should I go?

Verena Lang, Peter Hartmann, Alexander Schengel, Martin Maier

Methanotrophic bacteria are capable to uptake methane (CH4) from the atmosphere. They are mainly found in forest soils, making them the most important terrestrial sink for methane. While agricultural soils have partially lost their methane sink function due to the negative effect …

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Beyond one-size-fits-all: Estimating effective soil physical parameters for gas flux modelling

Valentin Gartiser, Verena Lang, Laurin Osterholt, Hubert Jochheim et autres

The flux-gradient method (FGM) is a versatile approach for modelling soil gas fluxes from concentration profiles. It is especially useful for continuous and long-term estimations of gas fluxes based on concentrations from permanently installed probes or sensors, focussing on relative changes and …

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