Roberto R. Ricardo-González

Mite-induced migratory skin-like CD103 + ILC2s establish lung residency and impact immunity

Mi Lian, Tithi Roy, Lena Tama, Fanglue Peng et autres

Summary Tissue-resident immune cells are critical for lung homeostasis and protection against inflammation. Here, we describe a novel population of migratory inflammatory CD103 + skin ILC2s (skILC2s) that accumulate in the lung vasculature following transient infestation with ubiquitous Demodex mites, hair follicle …

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Inflammatory migration-associated skin-like CD103+ ILC2s impact lung immunity 9270

Lian Mi, Tithi Roy, Hong-Erh Liang, Richard M. Locksley et autres

Abstract Description Group 2 innate lymphoid cells (ILC2s) are tissue-resident cells with transcriptional signatures imprinted by tissues in which they reside. Post-inflammatory expansion, migration and protective roles in distant organs have been described for small intestinal and bone marrow ILC2s, but whether …

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IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity

Victor S. Cortez, Sara Viragova, Satoshi Koga, Meizi Liu et autres

Adaptation of intestinal helminths to vertebrates involved the evolution of strategies to attenuate host tissue damage to support parasite reproduction and dissemination of offspring to the environment. Helminths initiate the IL-25-mediated tuft cell-type 2 innate lymphoid cell (ILC2) circuit that enhances barrier …

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Unrestrained MyD88 Signaling in A20-Deficient Keratinocytes Triggers T-Cell–Dependent Psoriatic Arthritis–Like Disease

Sugandh Kumar, Jared Liu, Nika Lenci, Ameneh Gharabi et autres

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RORγt eTACs mediate oral tolerance and Treg induction

Im‐Hong Sun, Anita Qualls, Han Yin, Jiaxi Wang et autres

The immune system must distinguish pathogens from innocuous dietary antigens, but the precise mechanisms and cellular actors remain unclear. Here, we demonstrate that RORγt-lineage APCs are required for oral tolerance. Using lineage tracing and single-cell sequencing, we show these APCs consist of …

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IL-25-induced memory ILC2s mediate long-term small intestinal adaptation

Victor S. Cortez, Sara Viragova, S Koga, Meizi Liu et autres

The adaptation of intestinal helminths to vertebrates evolved strategies to attenuate host tissue damage to support reproductive needs of parasites necessary to disseminate offspring to the environment. Helminths initiate the IL-25-mediated tuft cell-ILC2 circuit that enhances barrier protection of the host although …

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In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313

William A. Nyberg, Charlotte H. Wang, Jonathan Ark, Chang Liu et autres

T cells, including naive T cells. Ark313-mediated transgene delivery presents an efficient approach to target mouse T cells in vivo and a resource for the interrogation of T cell biology and for immunotherapy applications.

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A single-cell atlas of IL-23 inhibition in cutaneous psoriasis distinguishes clinical response

David Wu, Ashley Hailer, Sijia Wang, Michelle Yuan et autres

Psoriasis vulgaris and other chronic inflammatory diseases improve markedly with therapeutic blockade of interleukin-23 (IL-23) signaling, but the genetic mechanisms underlying clinical responses remain poorly understood. Using single-cell transcriptomics, we profiled immune cells isolated from lesional psoriatic skin before and during IL-23 …

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Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche

Jarish N. Cohen, Victoire Gouirand, Courtney E. Macon, Margaret M. Lowe et autres

Immune tolerance is maintained in lymphoid organs (LOs). Despite the presence of complex immune cell networks in non-LOs, it is unknown whether self-tolerance is maintained in these tissues. We developed a technique to restrict genetic recombination to regulatory T cells (T regs …

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Innate type 2 immunity controls hair follicle commensalism by Demodex mites

Roberto R. Ricardo-González, Maya E. Kotas, Claire E. O’Leary, Katelyn Singh et autres

Demodex mites are commensal parasites of hair follicles (HFs). Normally asymptomatic, inflammatory outgrowth of mites can accompany malnutrition, immune dysfunction, and aging, but mechanisms restricting Demodex outgrowth are not defined. Here, we show that control of mite HF colonization in mice required …

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012 Tissue-specific manipulation of regulatory T cells reveals the skin to be a site of immune tolerance

Joshua G. Cohen, J. Moreau, Victoire Gouirand, Courtney Macon et autres

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Innate type 2 immunity controls hair follicle commensalism by Demodex mites

Roberto R. Ricardo-González, Maya E. Kotas, Claire E. O’Leary, Iliana Tenvooren et autres

Abstract Demodex mites are obligate commensal parasites of hair follicles (HF) in mammals. Normally asymptomatic, inflammatory outgrowth of mites can accompany malnutrition, immune dysfunction and aging, but mechanisms restricting Demodex outgrowth and pathogenesis are not defined. Here, we show that control over …

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