신명수

A Sulfonamide Intermediate Elicits Therapeutic Effect Against Sepsis by Enhancing Neutrophil Maturation

Ji Ye Park, Yu Sun Jeong, 신명수, Jiwoo Choi et autres

ABSTRACT Sepsis, a life‐threatening condition characterized by systemic inflammation and immune dysregulation, remains a major cause of mortality worldwide. Here, we identify a synthetic sulfonamide intermediate, 1‐[5‐(2‐fluorophenyl)furan‐2‐yl]‐N‐(4‐methylbenzyl)methanamine (FMM), as a host‐directed therapeutic candidate that enhances neutrophil maturation and antimicrobial function via autophagy. …

kr (code pays fourni par la source)

Stereoselective Syntheses of Octadecanoids, 9( S )-HODE, and 9( S ),10( S ),13( S )-TriHOME

신명수, Youngjoo Byun

High Resolution Image Download MS PowerPoint Slide Octadecanoids and their metabolites are known to be biologically active lipid mediators. 9( S )-HODE and 9( S ),10( S ),13( S )-TriHOME, the main metabolites of linoleic acid produced by 15-lipoxygenase, exhibit enantioselective potency …

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Mechanism by which a linoleic acid metabolite suppresses cancer cell growth by inhibiting mTOR

Seung Ju Park, Sera Kim, Hongmok Kwon, Jiyeon Choi et autres

kr, us (code pays fourni par la source)

Anti-Proliferative Activity of Ethanol Extracts from Taxilli Ramulus (Taxillus chinensis (DC.) Danser) Through Cyclin D1 Proteasomal Degradation in Human Colorectal Cancer Cells

박광훈, Hun-min Song, 박수빈, 박지혜 et autres

In this study, we elucidated anti-cancer activity and potential molecular mechanism of 70% ethanol extracts from Taxilli Ramulus (Taxillus chinensis (DC.) Danser) (TR-E70) against human colorectal cancer cells. Anti-cell proliferative effect of TR-E70 was evaluated by MTT assay. The effect of TR-E70 …

독활 에탄올 추출물의 대장암 세포에서 Cyclin D1 단백질 분해 유도를 통한 세포 생육 억제활성

박수빈, 박광훈, 송훈민, 박지혜 et autres

Background: In this study, we evaluated the anti-cancer activity and potential molecular mechanism of 70% ethanol extracts of the root of Aralia cordata var. continentalis (Kitagawa) Y. C. Chu (RAc-E70) against human colorectal cancer cells. Methods and Results: RAc-E70 suppressed the proliferation …

폐고무 분말과 플라이애시를 포함한 개질유황 복합체의 강도 발현 특성

권성우, 신명수