Markus Wiederstein

Self-assembling proteins compose the chemically resistant shell biomaterial of planktonic tintinnid ciliates

Maximilian H. Ganser, Markus Wiederstein, Christof Regl, Laura A. Katz et autres

Biomaterials provide superior properties and sustainable alternatives relevant to medicine, textiles, and high-tech applications. Research has mainly focused on animal-derived proteinaceous biomaterials, which remain challenging to reproduce while retaining their remarkable properties. Here, we show that the shell biomaterial of tintinnid ciliates, …

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Self-assembling proteins compose the chemically resistant shell biomaterial of planktonic tintinnid ciliates (Supplementary Files)

Maximilian H. Ganser, Markus Wiederstein, Christof Regl, Laura A. Katz et autres

Supplementary Files to the Article "Self-assembling proteins compose the chemically resistant shell biomaterial of planktonic tintinnid ciliates", M. H. Ganser, M. Wiederstein, C. Regl, L. A. Katz & S. Agatha (2026), Nature Communications, DOI: https://doi.org/10.1038/s41467-026-74402-4

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Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures

Angelika Lahnsteiner, Victoria Ellmer, Esther Schönauer, Julia Huber et autres

BACKGROUND: The global prevalence of metabolic diseases (MetDs) continues to rise and is associated with an increased cancer risk. Genome-wide association studies have identified numerous single nucleotide variants (SNVs) linked to MetDs, some within genes also implicated in tumorigenesis. G-quadruplexes (G4s) are …

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Additional file 2 of Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures

Angelika Lahnsteiner, Victoria Ellmer, Esther Schönauer, Julia Huber et autres

Additional file 2: Contains Supplementary Methods and figures Figs. S1-S19.

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Additional file 2 of Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures

Angelika Lahnsteiner, Victoria Ellmer, Esther Schönauer, Julia Huber et autres

Additional file 2: Contains Supplementary Methods and figures Figs. S1-S19.

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Additional file 1 of Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures

Angelika Lahnsteiner, Victoria Ellmer, Esther Schönauer, Julia Huber et autres

Additional file 1: Contains Supplementary Tables S1-S18.

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Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures

Angelika Lahnsteiner, Victoria Ellmer, Esther Schönauer, Julia Huber et autres

Abstract Background The global prevalence of metabolic diseases (MetDs) continues to rise and is associated with an increased cancer risk. Genome-wide association studies have identified numerous single nucleotide variants (SNVs) linked to MetDs, some within genes also implicated in tumorigenesis. G-quadruplexes (G4s) …

at, cz (code pays fourni par la source)

Additional file 1 of Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures

Angelika Lahnsteiner, Victoria Ellmer, Esther Schönauer, Julia Huber et autres

Additional file 1: Contains Supplementary Tables S1-S18.

at, cz (code pays fourni par la source)

Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures

Angelika Lahnsteiner, Victoria Ellmer, Esther Schönauer, Julia Huber et autres

Abstract Background The global prevalence of metabolic diseases (MetDs) continues to rise and is associated with an increased cancer risk. Genome-wide association studies have identified numerous single nucleotide variants (SNVs) linked to MetDs, some within genes also implicated in tumorigenesis. G-quadruplexes (G4s) …

at, cz (code pays fourni par la source)

A new class of proteinaceous biomaterial with unprecedented properties in unicellular eukaryotes

Maximilian H. Ganser, Markus Wiederstein, Christof Regl, Laura A. Katz et autres

Abstract Biomaterials fundamentally reshape material use, providing superior properties and sustainable alternatives relevant to medicine, textiles, and high-tech applications. Research mainly focuses on animal-derived proteinaceous biomaterials, which remain challenging to reproduce while retaining their remarkable properties. We discovered that the shells of …

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Iron-Dependent allergenicity of Alt a 1: A link between fungal nutritional immunity and allergic sensitization

Aila Fakhimahmadi, Karin Hufnagl, Ilir Hasanaj, Nathalie Szepannek et autres

The major fungal allergen Alt a 1 from Alternaria alternata is linked to allergic asthma. We assessed its biological role in nutritional immunity to iron and its allergenic potential using in silico, in vitro, and in vivo approaches. Alternaria was cultured with …

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SNPs associated with Metabolic Disorders Disrupt Structural Properties of DNA G-Quadruplexes in Regulatory Regions relevant during Tumor Development

Angelika Lahnsteiner, Victoria Ellmer, Esther Schönauer, Markus Wiederstein et autres

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