Balázs Varga

Focal white matter lesions drive grey matter inflammation and synapse loss

Omar de Faria, Stavros Vagionitis, Andrea López-López, Michael Perry et autres

Abstract Focal white matter lesions occur in most neurodegenerative disorders 1–3 . Despite occurring early in disease, white matter lesions are considered to be independent of, or secondary to, grey matter neuroinflammation, synapse loss and altered neuronal activity 4–7 . Notably, their …

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Focal white matter lesions drive grey matter inflammation and synapse loss.

Omar de Faria, Stavros Vagionitis, Andrea López-López, Michael Perry et autres

Heterogeneity in oligodendrocyte precursor cell proliferation is dynamic and driven by passive bioelectrical properties

Helena Pivoňková, Sergey Sitnikov, Yasmine Kamen, An Vanhaesebrouck et autres

Oligodendrocyte precursor cells (OPCs) generate myelinating oligodendrocytes and are the main proliferative cells in the adult central nervous system. OPCs are a heterogeneous population, with proliferation and differentiation capacity varying with brain region and age. We demonstrate that during early postnatal maturation, …

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iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer

Dong Shin Park, Tatsuya Kozaki, Satish Kumar Tiwari, Marco Moreira et autres

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Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

Makis Tzioras, Michael J. Daniels, C. T. M. Davies, Paul Baxter et autres

Synapse loss correlates with cognitive decline in Alzheimer's disease (AD). Data from mouse models suggests microglia are important for synapse degeneration, but direct human evidence for any glial involvement in synapse removal in human AD remains to be established. Here we observe …

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Corrigendum: Electrochemically induced in vitro focal hypoxia in human neurons

Joseph J. Y. Wong, Balázs Varga, Ragnhildur Thóra Káradóttir, Elizabeth A. H. Hall

[This corrects the article DOI: 10.3389/fcell.2022.968341.].

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Electrochemically induced in vitro focal hypoxia in human neurons

Joseph J. Y. Wong, Balázs Varga, Ragnhildur Thóra Káradóttir, Elizabeth A. H. Hall

Focalised hypoxia is widely prevalent in diseases such as stroke, cardiac arrest, and dementia. While in some cases hypoxia improves cellular functions, it mostly induces or exacerbates pathological changes. The lack of methodologies that can simulate focal acute hypoxia, in either animal …

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Signal requirement for cortical potential of transplantable human neuroepithelial stem cells

Balázs Varga, Maryam Faiz, Helena Pivoňková, Gabriel Khelifi et autres

The cerebral cortex develops from dorsal forebrain neuroepithelial progenitor cells. Following the initial expansion of the progenitor cell pool, these cells generate neurons of all the cortical layers and then astrocytes and oligodendrocytes. Yet, the regulatory pathways that control the expansion and …

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Periods of synchronized myelin changes shape brain function and plasticity

Omar de Faria, Helena Pivoňková, Balázs Varga, Sebastian Timmler et autres

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(IMCS First Place Best Paper Award) Local Hypoxia System as a Sensing Interface of Cellular Responses

Joseph J. Y. Wong, Balázs Varga, Ragnhildur Thóra Káradóttir, Elizabeth Hall

Oxygen concentration is one of the critical factors tightly controlled in each part of an organism to regulate the cells’ role and function. Yet, changes in tissue oxygenation often occur in small focal areas with aging or as a result of an …

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Transplantation of Human Cortically-Specified Neuroepithelial Progenitor Cells Leads to Improved Functional Outcomes in a Mouse Model of Stroke

Rehnuma Islam, Stasja Drecun, Balázs Varga, Ilan Vonderwalde et autres

Stroke is a leading cause of death and long-term disability worldwide. Current therapeutic options are limited in terms of their time for implementation and efficacy in promoting recovery. Cell transplantation has been shown to have promise in several animal models however significant …

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Microglial exosomes: taking messaging to new spheres

Deborah Kronenberg‐Versteeg, Balázs Varga

This scientific commentary refers to ‘The influence of the R47H TREM2 variant on microglial exosome profiles’ by Mallach et al. (https://doi.org/10.1093/braincomms/fcab009). The negative impact of neurodegenerative conditions on life quality has been increasing due to the lengthening of human lifespan. It is …

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