Tsuyoshi Takara

Effects of Soybean-derived Phosphatidylserine on Working Memory and Motor Speed in Healthy Adults with Subjective Memory Complaints: A 12-Week Randomized, Placebo-Controlled Trial

Yin Liu, Yunping Tang, Neoh Galex K.S., Yangfan Lu et autres

Phosphatidylserine (PS) is a functional phospholipid widely studied for cognitive support, yet evidence in healthy adults with subjective cognitive decline remains limited. This 12-week randomized, double-blind, placebo-controlled trial evaluated the safety and cognitive effects of 300 mg/day of soybean-derived PS in 70 …

us, cn, jp (code pays fourni par la source)

Orally administered scallop-derived plasmalogens improve cognitive function in healthy middle-aged and older adults: a randomized, double-blind, placebo-controlled trial

Mina Fukuchi, Mizuho Tanaka, Masafumi Nagata, Tsuyoshi Takara et autres

Background: Plasmalogens (Pls) are ether phospholipids enriched in the brain that help maintain synaptic integrity and support cognitive function. However, evidence of their cognitive benefits in otherwise healthy individuals remains limited. This randomized, double-blind, placebo-controlled trial examined whether supplementation with scallop-derived Pls …

jp, se (code pays fourni par la source)

Ampelopsin-rich ResoVine™ reduces abdominal fat area in healthy Japanese participants

Tsuyoshi Takara, Masafumi Nagata, Kazuo Yamamoto, Naoko Suzuki et autres

Background: Vine tea, which is rich in ampelopsin, has demonstrated beneficial effects on lipid metabolism and adiposity in preclinical studies. However, clinical evidence of its effects on body fat remains limited. Objective: This study evaluated the effects of ResoVine™-P, a standardized vine …

jp (code pays fourni par la source)

Cognitive improvement by daily intake of coffee cherry pulp extract from Coffea canephora var. Robusta in a Japanese population: A randomized, placebo-controlled, double-blind, parallel-group comparison trial

Shingo Ariki, Rikito Mitsuzane, Shiori Morimoto, Mao Nakagawa et autres

BACKGROUND: In coffee-producing regions, coffee cherry pulp is usually discarded despite its potential bioactivity. This study examined the effects of coffee cherry pulp extract from Coffea canephora var. Robusta (CCPER) on cognitive function in healthy adults and its neurite outgrowth effect on …

jp (code pays fourni par la source)

Effect of D-β-Hydroxybutyric Acid on Body Fat in Japanese Adults: A Randomized, Double-Blind, Placebo-Controlled Study

Shohei Katsuya, Yoshikazu Kawata, Jun Kawamura, Tsuyoshi Goto et autres

Ketone metabolism is currently being spotlighted for its health benefits. Strict dietary carbohydrate restriction is required to increase plasma ketone levels, which can be achieved with D-β-hydroxybutyric acid (D-BHB) supplementation as well. Although 2.9 g/day of D-BHB may reduce body fat without …

jp (code pays fourni par la source)

Apple Polyphenols and Defecation in Overweight Adults with Constipation – A Randomized Controlled Trial

Takahiro Sekikawa, Yanmei Li, Tsuyoshi Takara

Constipation is a prevalent symptom in adults and has been linked to an increased risk of serious complications, including cardiovascular and renal diseases. This study evaluated the effect of apple polyphenols on defecation among Japanese adults with a body mass index of …

se (code pays fourni par la source)

Effect of Probiotic Drinks Containing 2,3-Dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one on Cognitive Function of Middle-Aged and Older Individuals

Taiki Sato, Shuichi Segawa, Shin-ichiro Iio, Tsuyoshi Takara

The compound 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP) possesses antioxidant properties; however, its effects on cognitive function are unclear. This study examined the effects of DDMP-containing beverages on the cognitive function of healthy middle-aged and older Japanese individuals. We conducted a randomized, double-blind, and placebo-controlled parallel …

jp, se (code pays fourni par la source)

Effects of Consumption of Black Soybean Seed Coat Extract on Sleep Quality in Healthy Japanese: A Randomized, Placebo‐Controlled, Double‐Blind, Parallel‐Group Comparison Study

Ryota Akagi, T. Maruo, Tsuyoshi Takara, Kentaro Maruyama

ABSTRACT This study examined the effect of the intake of a test food containing black soybean seed coat extract (BE) on the sleep quality of healthy Japanese adults with poor sleep quality. This double‐blind, placebo‐controlled, randomized, parallel‐group trial included 94 participants. We …

jp (code pays fourni par la source)

Safety study of Lutein (VitaLutein®) in healthy Japanese adults: A randomized, placebo-controlled, double-blind, parallel-group comparative study

Hyunjin Lee, T. Itano, Faizal Mohamed, Naoko Suzuki et autres

Background Lutein is a natural pigment with antioxidant properties, present in the eye's lens and macula. Daily exposure to light—particularly blue and infrared wavelengths—increases the eyes' vulnerability to oxidative damage caused by free radicals. However, lutein’s antioxidant effect helps protect against this …

jp (code pays fourni par la source)

Supplementation with heat-sterilized Lactobacillus crispatus strain KT-11 stimulates the T cell–related immune function of healthy Japanese adults: A pilot randomized, placebo-controlled, double-blind, parallel-group study

Itsuki Watanabe, Naoko Suzuki, Tsuyoshi Takara

jp (code pays fourni par la source)

Effects of the consumption of Acacia bark-derived proanthocyanidins on visceral fat: A randomized, double-blind, placebo-controlled, parallel-group comparative study

Asami Baba, Sosuke Ogawa, Kengo Yokosho, Naoko Suzuki et autres

Background: Obesity is an important risk factor for diabetes, kidney, liver, and cardiovascular diseases, and chronic obstructive pulmonary diseases. Factors such as dietary choices, decreased physical activity due to urbanization and economic expansion, and increased nutritional consumption have made obesity a growing …

jp (code pays fourni par la source)

Effectiveness of Partially Hydrolyzed Guar Gum on Cognitive Function and Sleep Efficiency in Healthy Elderly Subjects in a Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study

Aya K. Abe, Mahendra Parkash Kapoor, So Morishima, Makoto Ozeki et autres

The consumption of functional foods in a daily diet is a promising approach for the maintenance of cognitive health. The present study examines the effects of water-soluble prebiotic dietary-fiber, partially hydrolyzed guar gum (PHGG), on cognitive function and mental health in healthy …

jp (code pays fourni par la source)