Accès ouvert
2026
article
OpenAlex
Fleur E Groualle, David Onion, Julie A. Watts, Graham A. Rance et autres
ABSTRACT Disruption of membrane potential (V mem ) can activate pathways associated with cancer proliferation. Manipulating ion channels may therefore present an effective strategy for treating cancers that fail to respond to conventional therapies. One approach to target these channels is to …
gb, us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Fleur E Groualle, David Onion, Julie Watts, Graham A. Rance et autres
ABSTRACT The membrane potential (V mem ) and faradaic charge transfer, resulting from altered charge distribution due to ion channels, play a crucial role in cellular bioelectricity. Disruption of V mem can activate pathways associated with cancer proliferation. Manipulating ion channels may …
gb, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Jessica Oliveira de Santis, Graziella Ribeiro de Sousa, Rosane Gomes de Paula Queiróz, Marina Ferreira Cândido et autres
Medulloblastoma (MB) is the most common malignant brain tumor in children, comprising four distinct subgroups: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4. MYC amplification and metastatic dissemination are challenges in clinical management, and tumor-associated macrophages (TAMs) play an essential …
br, gb
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Akhil Jain, Philippa Wade, Snow Stolnik, Alistair N. Hume et autres
Abstract Resistance mechanisms in brain tumors, such as medulloblastoma and glioblastoma, frequently involve the entrapment of chemotherapeutic agents within endosomes and the extracellular expulsion of drugs. These barriers to effective treatment are exacerbated in nanotechnology-based drug delivery systems, where therapeutic nanoparticles often …
gb, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Niek van Bree, Ann-Sophie Oppelt, Susanne Lindström, Leilei Zhou et autres
BACKGROUND: Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Current preclinical in vivo model systems for MB have increased our understanding of molecular mechanisms regulating MB development. However, they may not be suitable for large-scale studies. The …
se, gb
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
Danai Stella Gkotsi, Isabelle Forder-Denham, Timothy Ritzmann, Judith M. Ramage et autres
Abstract BACKGROUND Paediatric brain tumours pose a formidable challenge in oncology, necessitating innovative approaches to bridge the gap between molecular understanding and therapeutic efficacy. Current preclinical models lack fidelity in capturing the dynamic interplay between tumour cells and their microenvironment, hindering translation …
gb
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
Joseph D. Allen, Susannah Entwistle, Beth Coyle, Alistair N. Hume
Abstract BACKGROUND Medulloblastoma is the most common solid paediatric neoplasm and is among the leading causes of cancer-related deaths in children. Patients associated with high-risk molecular subgroups convey poor outcomes due to frequent relapse and metastasis, with two thirds of survivors experiencing …
gb
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
Isabelle Forder-Denham, Ian D. Kerr, Andrew M. Jackson, Beth Coyle
Abstract BACKGROUND Medulloblastoma is the most common malignant childhood brain-tumour, predominantly affecting children between the ages of one and nine. It is divided into four molecular subgroups amongst which, Group 3 (G3) and Group 4 (G4) subgroups have the worst prognosis. Subgroups …
gb
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
Connor T. Levers, Hannah K. Jackson, Ian D. Kerr, Federico Dajas‐Bailador et autres
Abstract BACKGROUND Small Extracellular Vesicles (sEVs) are major intercellular communicators, with growing evidence of a role in establishing favourable metastatic niches during cancer progression. We have shown that, relative to their paired primary counterpart, Group 4 (Grp4) metastatic Medulloblastoma (MB) cell-lines release …
gb
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
Hannah K. Jackson, Anna M. Grabowska, Victoria James, Federico Dajas‐Bailador et autres
Abstract BACKGROUND Childhood cancer-related pain and its treatment lack sufficient clinical attention due to limited understanding of the underlying mechanisms. While chemotherapy-induced peripheral neuropathic pain (CIPN) mechanisms in adults have been extensively studied, those in early life remain unexplored. In the CIPN …
gb
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Akhil Jain, Philippa Wade, Snow Stolnik, Alistair N. Hume et autres
Abstract Chemotherapy resistance and endosomal entrapment, controlled by intracellular trafficking processes, are major factor in treatment failure. Here, we test the hypothesis that external electrical stimulus can be used to modulate intracellular trafficking of chemotherapeutic drugs in most common malignant brain tumors …
gb
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Ursula S. Sandau, Setty M. Magaña, Júlia Costa, John P. Nolan et autres
Cerebrospinal fluid (CSF) is a clear, transparent fluid derived from blood plasma that protects the brain and spinal cord against mechanical shock, provides buoyancy, clears metabolic waste and transports extracellular components to remote sites in the brain. Given its contact with the …
us, pt, au, gb, cr, gr, es, nl
(code pays fourni par la source)