Ser Sue Ng

Author Correction: The kinase TNIK is an essential activator of Wnt target genes (The EMBO Journal, (2009), 28, 21, (3329-3340), 10.1038/emboj.2009.285)

Tokameh Mahmoudi, Vivian SW Li, Ser Sue Ng, Nadia Taouatas et autres

After being informed of a potential microduplication in Figure 1D, the journal contacted the authors for clarification. The authors provided the original source data, which confirms that no duplication occurred in the original dataset. For transparency, the original source data is published …

Author Correction: The kinase TNIK is an essential activator of Wnt target genes

Tokameh Mahmoudi, Vivian Li, Ser Sue Ng, Nadia Taouatas et autres

After being informed of a potential microduplication in Figure 1D, the journal contacted the authors for clarification. The authors provided the original source data, which confirms that no duplication occurred in the original dataset. For transparency, the original source data is published …

nl (code pays fourni par la source)

The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD (Adv. Sci. 35/2024)

Zun Siong Low, Damien Chua, Hong Sheng Cheng, Rachel Tee et autres

Metabolic Dysfunction-Associated Steatotic Liver Disease The LIDPAD model, a single-mouse metabolic dysfunction-associated steatotic liver disease (MASLD) model using thermoneutral housing and refined diet, replicates key human MASLD features, such as metabolic syndrome, gut dysbiosis, multiorgan dysfunction, and neurobehavioral anomalies in a short …

The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD

Zun Siong Low, Damien Chua, Hong Sheng Cheng, Rachel Tee et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents an impending global health challenge. Current management strategies often face setbacks, emphasizing the need for preclinical models that faithfully mimic the human disease and its comorbidities. The liver disease progression aggravation diet (LIDPAD), a diet-induced …

sg, cn, us, gb, fr, ch (code pays fourni par la source)

Angiopoietin-like 4 shapes the intrahepatic T-cell landscape via eIF2α signaling during steatohepatitis in diet-induced NAFLD

Zun Siong Low, Damien Chua, Hong Sheng Cheng, Rachel Tee et autres

ABSTRACT Adaptive T-cell immune response is essential in conferring protective immunity, a process requiring tight cellular homeostasis regulation. Pathological intrahepatic T-cell landscape has a role in NAFLD propagation; however, its activation remains unknown. To address this gap, we extensively characterized a novel …

sg, cn, us, gb, fr, ch (code pays fourni par la source)

Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

Jiajia Ma, Claire A. Scott, Ying Na Ho, Harsha Mahabaleshwar et autres

Epithelial tissues are primed to respond to insults by activating epithelial cell motility and rapid inflammation. Such responses are also elicited upon overexpression of the membrane-bound protease, Matriptase, or mutation of its inhibitor, Hai1. Unrestricted Matriptase activity also predisposes to carcinoma. How …

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Author response: Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

Jiajia Ma, Claire A. Scott, Ying Na Ho, Harsha Mahabaleshwar et autres

The serine protease Matriptase orchestrates simultaneous epithelial cell motility and inflammation in pathological states through respective activation of the MAPK pathway and generation of hydrogen peroxide.

sg, gb (code pays fourni par la source)

Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis

Jung Eun Park, Gnanasekaran JebaMercy, Kalailingam Pazhanchamy, Xue Guo et autres

sg, nz, gb, nl (code pays fourni par la source)

Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis

Jung Eun Park, Gnanasekaran JebaMercy, Kalailingam Pazhanchamy, Xue Guo et autres

Abstract Background and Aims Aging is the primary risk factor for cardiovascular disease (CVD), but the mechanisms underlying age-linked atherosclerosis remain unclear. We previously observed that long-lived vascular matrix proteins can acquire ‘gain-of-function’ isoDGR motifs that might play a role in atherosclerotic …

sg, nz, gb, nl (code pays fourni par la source)

Increased isoDGR motifs in plasma fibronectin are associated with atherosclerosis through facilitation of vascular fibrosis

Jung Eun Park, Xue Guo, Ken Cheng Kang Liou, Soe EinSi Lynn et autres

Abstract Abnormal matrix deposition on vessels and recruitment of inflammatory cells into the arterial wall are critical events in atherosclerotic plaque formation. Fibronectin protein is a key matrix component that exhibits high levels of deamidation in atherosclerotic plaques and blood plasma, but …

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Pulsed SILAM Reveals In Vivo Dynamics of Murine Brain Protein Translation

Ser Sue Ng, Jung Eun Park, Wei Meng, Christopher Chen et autres

Identification of proteins that are synthesized de novo in response to specific microenvironmental cues is critical for understanding molecular mechanisms that underpin vital physiological processes and pathologies. Here, we report that a brief period of SILAM (Stable Isotope Labeling of Mammals) diet …

sg, cn, fr, gb, au (code pays fourni par la source)

Dynamics of murine brain protein synthesis in vivo identify the hippocampus, cortex and cerebellum as highly active metabolic sites

Ser Sue Ng, Jung Eun Park, Wei Meng, Christopher Chen et autres

Abstract Identification of proteins that are synthesized de novo in response to specific microenvironmental cues is critical to understanding the molecular mechanisms that underpin key physiological processes and pathologies. Here we report that a brief period of pulsed SILAC diet (Stable Isotope …

sg, gb (code pays fourni par la source)