2026
article
OpenAlex
Bridget Kelly, Emily Buttigieg, Fei Cai, Nicholas Burns et autres
BACKGROUND: Robust ambulatory clinic teaching can better prepare residents for ambulatory practice. The objective of this study was to implement a standardized ambulatory clinic curriculum in obstetrics and gynecology (OB-GYN) residency training and evaluate its feasibility and acceptability. METHODS: A curriculum consisting …
us
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2022
article
OpenAlex
Bridget Kelly, Emily Buttigieg
us
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Accès ouvert
2022
article
OpenAlex
Marissa Cloutier, Surinder Kumar, Emily Buttigieg, Laura Keller et autres
X-chromosome inactivation is a paradigm of epigenetic transcriptional regulation. Female human embryonic stem cells (hESCs) often undergo erosion of X-inactivation upon prolonged culture. Here, we investigate the sources of X-inactivation instability by deriving new primed pluripotent hESC lines. We find that culture …
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Accès ouvert
2015
article
OpenAlex
Mrinal K. Sarkar, Srimonta Gayen, Surinder Kumar, Emily Maclary et autres
The transcriptional imbalance due to the difference in the number of X chromosomes between male and female mammals is remedied through X-chromosome inactivation, the epigenetic transcriptional silencing of one of the two X chromosomes in females. The X-linked Xist long non-coding RNA …
us, jp
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Accès ouvert
2015
article
OpenAlex
Srimonta Gayen, Emily Maclary, Emily Buttigieg, Michael Hinten et autres
Differentiating pluripotent epiblast cells in eutherians undergo random X-inactivation, which equalizes X-linked gene expression between the sexes by silencing one of the two X-chromosomes in females. Tsix RNA is believed to orchestrate the initiation of X-inactivation, influencing the choice of which X …
us
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Accès ouvert
2014
article
OpenAlex
Emily Maclary, Emily Buttigieg, Michael Hinten, Srimonta Gayen et autres
us
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