Weiguo Yao

Investigating the Effects of Moxibustion on Gastrointestinal Function and Gut Microbiota in Chronic Renal Failure: A CARE Non-Placebo Randomized Controlled Study in Peritoneal Dialysis Patients

Weiguo Yao, Chunli Yu, Aiying Xiong, Li Li et autres

INTRODUCTION: Moxibustion is regarded as a complementary and alternative treatment for chronic renal failure (CRF) patients. METHODS: This study was a randomized controlled trial, and we collected case data from 52 CRF patients who received moxibustion combined with PD treatment (moxibustion group) …

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Associations between the intake of single and multiple dietary vitamins and depression risk among populations with chronic kidney disease

Chunli Yu, Kun Liu, Weiguo Yao, Dingzhong Tang

Background The effects of multivitamin exposure on depression among patients with chronic kidney disease (CKD) have not been thoroughly explored. This study aimed to explore the effects of individual vitamin intakes and the joint effect of the intake of multiple vitamins (including …

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Effect of Acupuncture Intervention on Chronic Musculoskeletal Pain in Hemodialysis-Dependent Kidney Failure Patients: Study Protocol for a Randomized Controlled Clinical Trial

Cuina Yan, Huirong Liu, Qi Kong, Jia Hui Gan et autres

Background: Chronic musculoskeletal pain is prevalent in individuals with hemodialysis-dependent renal failure (HDKF). The current opioid crisis highlights the urgent need for effective non-pharmacological pain management. Acupuncture, identified as a non-pharmacological intervention in clinical settings, holds promise for alleviating chronic musculoskeletal pain …

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Serum glucose mediated association of serum lactate with acute kidney injury among AIS patients

Chunli Yu, Weiguo Yao, Kun Liu, Dingzhong Tang

BACKGROUND: The serum lactate level has been confirmed to be an independent risk factor for the occurrence of acute kidney injury (AKI) in many diseases. However, the correlation between serum lactate level and AKI in critical patients with acute ischemic stroke (AIS) …

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The Effect of Acupuncture Intervention on Chronic Musculoskeletal Pain in HDKF Patients: Study Protocol for A Randomized Controlled Clinical Trial

Cui-Na Yan, Huirong Liu, Qi Kong, Jiayi Gan et autres

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The Effects of serum glucose level on the association of between serum lactate level and acute kidney injury among critical patient with acute ischemic stroke

Chunli Yu, Weiguo Yao, Kun Liu, Dingzhong Tang

Abstract Background: Serum lactate level has been confirmed to be an independent risk factor for the occurrence of acute kidney injury (AKI) in many diseases. However, the correlation between serum lactate level and AKI in critical patients with acute ischemic stroke (AIS) …

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Allelochemicals-mediated interaction between algae and bacteria: Direct and indirect contact

Jie Fan, Xingyu Du, Huangbo Zhao, Weiguo Yao

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Immunological evaluation of an mRNA vaccine booster in individuals fully immunized with an inactivated SARS‐CoV‐2 vaccine

Xingli Xu, Yun Liao, Guorun Jiang, Weiguo Yao et autres

Immunological evaluation of an mRNA vaccine booster in individuals fully immunized with an inactivated SARS-CoV-2 vaccineDear Editor, More than 5.75 million deaths and 396.55 million cases of coronavirus disease 2019 (COVID-19) have been reported, including those caused by at least five variants …

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Quercetin attenuates the proliferation, inflammation, and oxidative stress of high glucose-induced human mesangial cells by regulating the miR-485-5p/YAP1 pathway

Huan Ying Wan, Yaping Wang, Qingyun Pan, Xia Chen et autres

BACKGROUND: Diabetic nephropathy (DN) is a kidney damage caused by diabetes and the main cause of end-stage renal disease. However, the current treatment of DN has many limitations. Quercetin is a bioflavonoid compound with therapeutic benefits in metabolic diseases. This study aims …

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A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity

Ren Yang, Yao Liang Deng, Baoying Huang, Lei Huang et autres

Although inoculation of COVID-19 vaccines has rolled out globally, there is still a critical need for safe and effective vaccines to ensure fair and equitable supply for all countries. Here, we report on the development of a highly efficacious mRNA vaccine, SW0123 …

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Heterologous vaccination strategy for containing COVID-19 pandemic

Ang Lin, Jingjing Liu, Xiaopin Ma, Fanfan Zhao et autres

Summary An unequitable vaccine allocation and continuously emerging SARS-CoV-2 variants pose challenges to contain the pandemic, which underscores the need for licensing more vaccine candidates, increasing manufacturing capacity and implementing better immunization strategy. Here, we report data from a proof-of-concept investigation in …

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Algorithm for Optimized mRNA Design Improves Stability and Immunogenicity

He Zhang, Liang Zhang, Ang Lin, Congcong Xu et autres

Messenger RNA (mRNA) vaccines are being used for COVID-19, but still suffer from the critical issue of mRNA instability and degradation, which is a major obstacle in the storage, distribution, and efficacy of the vaccine. Previous work showed that optimizing secondary structure …

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