Ulrike Schumann

P08.06.B THE EGFL7-INTEGRIN Β2 AXIS: A NOVEL REGULATOR OF IMMUNE EVASION IN GLIOBLASTOMA

Sudipta Mahajan, Patrick M. Abe, Felix Ehret, C. Fabian et autres

Abstract BACKGROUND Glioblastoma is the most aggressive form of malignant brain cancer, characterized by an immunosuppressive environment that leads to immune evasion. Multiple strategies have been undertaken to shift the immune landscape within the glioma microenvironment (GME) to an anti-tumorigenic state, with …

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EGFL7, an Angiogenic Protein, Acts as an Immunosuppressive Factor in Glioma Development

Sukrit Mahajan, Mirko H. H. Schmidt, Ulrike Schumann

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P-03.06 EGFL7, an angiogenic factor, induces immunosuppression in malignant glioma

Sudipta Mahajan, Ulrike Schumann

Background Glioma is the most aggressive form of primary brain tumor, characterized by immune evasion, rapid growth, extensive angiogenesis and peritumoral invasion into the brain parenchyma. Recent evidence indicates that epidermal growth factor-like protein 7 (EGFL7), a known angiogenic factor, is highly …

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c-Cbl Regulates Murine Subventricular Zone-Derived Neural Progenitor Cells in Dependence of the Epidermal Growth Factor Receptor

Maximilian Vogt, Madhukrishna Kolothara Unnikrishnan, Nora Heinig, Ulrike Schumann et autres

The localization, expression, and physiological role of regulatory proteins in the neurogenic niches of the brain is fundamental to our understanding of adult neurogenesis. This study explores the expression and role of the E3-ubiquitin ligase, c-Cbl, in neurogenesis within the subventricular zone …

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Correction: EGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory

Kathrin Barth, Verica Vasić, Brennan McDonald, Nora Heinig et autres

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The Glioma Immune Landscape: A Double-Edged Sword for Treatment Regimens

Sukrit Mahajan, Mirko H. H. Schmidt, Ulrike Schumann

Immune cells constitute a major part of the tumor microenvironment, thereby playing an important role in regulating tumor development. They interact with tumor cells, resulting in the suppression or promotion of glioma development. Therefore, in recent years, scientists have focused on immunotherapy …

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EGFL7 loss correlates with increased VEGF-D expression, upregulating hippocampal adult neurogenesis and improving spatial learning and memory

Kathrin Barth, Verica Vasić, Brennan McDonald, Nora Heinig et autres

Neural stem cells reside in the subgranular zone, a specialized neurogenic niche of the hippocampus. Throughout adulthood, these cells give rise to neurons in the dentate gyrus, playing an important role in learning and memory. Given that these core cognitive processes are …

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Gamma Irradiation Triggers Immune Escape in Glioma-Propagating Cells

Nicola Hoppmann, Nora Heinig, Ute Distler, Ella Kim et autres

Glioblastoma multiforme is the most common and devastating form of brain tumor for which only palliative radio- and chemotherapy exists. Although some clinical studies on vaccination approaches have shown promising efficacy due to their potential to generate long-term immune surveillance against cancer …

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Less is more - loss of EGFL7 improves memory by upregulation of VEGF-D

Verica Vasić, Kathrin Barth, Frank Bicker, Ulrike Schumann et autres

Abstract Neural stem cells reside in a specialized neurogenic niche of the hippocampus termed the subgranular zone. Throughout life, they give rise to adult-born neurons in the dentate gyrus thereby contributing to learning and memory. Here, we report that neurons together with …

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Targeting Immune Modulators in Glioma While Avoiding Autoimmune Conditions

Lynn Bitar, Ulrike Schumann, Renate König, Frauke Zipp et autres

Communication signals and signaling pathways are often studied in different physiological systems. However, it has become abundantly clear that the immune system is not self-regulated, but functions in close association with the nervous system. The neural-immune interface is complex; its balance determines …

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Photobiomodulation Mediates Neuroprotection against Blue Light Induced Retinal Photoreceptor Degeneration

Nora Heinig, Ulrike Schumann, Daniela Calzia, Isabella Panfoli et autres

Potent neuroprotective effects of photobiomodulation with 670 nm red light (RL) have been demonstrated in several models of retinal disease. RL improves mitochondrial metabolism, reduces retinal inflammation and oxidative cell stress, showing its ability to enhance visual function. However, the current knowledge …

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Light‐induced oxidative stress production in the rod outer segments

Isabella Panfoli, Daniela Calzia, Nora Heinig, Ulrike Schumann et autres

Purpose Oxidative stress is involved in retinal diseases such as diabetic retinopathy, age‐related macular degeneration and retinal damage by light, characterized by Reactive Oxygen Intermediates (ROI) production. Rod Outer Segments (OS), display a mitochondria‐like activity, producing ATP and consuming oxygen through the …

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