Daniel Maunder

POS1371 A UNIQUE CIRCULATING SOLUBLE SERUM MEDIATOR PROFILE, TREG EXPANSION AND IL-6 INDUCED STAT3 PHOSPHORYLATION IN CD4+ T CELLS ARE BIOMARKERS OF DISEASE FLARE IN RHEUMATOID ARTHRITIS

Amy E. Anderson, Fiona Rayner, J. Swift, Daniel Maunder et autres

Background: Little is known of the factors that trigger disease relapses/flares in patients with rheumatoid arthritis (RA). These mechanisms have been difficult to study due to the unpredictable nature of flare. The BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (BIO-FLARE) …

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Micro-RNA content of circulating extracellular vesicles in early rheumatoid arthritis as biomarkers and mediators of methotrexate efficacy

Daniel Maunder, Philip M. Brown, Ben Barron‐Millar, Dennis Lendrem et autres

OBJECTIVES: Extracellular vesicles (EVs) are abundant in body fluids, contributing to intercellular signalling by transferring cargo that includes microRNAs (miRs)-themselves implicated in pathobiology. For the first time we evaluated the potential of EV miRs to contribute diagnostic information in early RA, predict …

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P114 Exploring micro-RNA content of circulating extracellular vesicles as biomarkers in early rheumatoid arthritis

Daniel Maunder, Philip M. Brown, Ben Barron‐Millar, Dennis Lendrem et autres

Abstract Background/Aims Early diagnosis and prompt and effective intervention for people with immune-mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis (RA) improves outcomes. Non-invasive biomarkers that reflect unique aspects of underlying biology could facilitate this. Extracellular vesicles (EVs) released by many cell …

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Blood and immune development in human fetal bone marrow and Down syndrome

Laura Jardine, Simone Webb, Issac Goh, Mariana Quiroga Londoño et autres

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Comparison of heat-inactivated and infectious SARS-CoV-2 across indoor surface materials shows comparable RT-qPCR viral signal intensity and persistence

Rodolfo A. Salido, Victor Cantu, Alex E. Clark, Sandra L. Leibel et autres

Abstract Environmental monitoring in public spaces can be used to identify surfaces contaminated by persons with COVID-19 and inform appropriate infection mitigation responses. Research groups have reported detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) on surfaces days or weeks after …

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Automated, miniaturized, and scalable screening of healthcare workers, first responders, and students for SARS-CoV-2 in San Diego County

Sydney Morgan, Stefan Aigner, Catelyn Anderson, Pedro Belda‐Ferre et autres

Abstract Background Successful containment strategies for SARS-CoV-2, the causative virus of the COVID-19 pandemic, have involved widespread population testing that identifies infections early and enables rapid contact tracing. In this study, we developed a rapid and inexpensive RT- qPCR testing pipeline for …

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Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome

Laura Jardine, Simone Webb, Issac Goh, Mariana Quiroga Londoño et autres

Abstract Throughout postnatal life, haematopoiesis in the bone marrow (BM) maintains blood and immune cell production. Haematopoiesis first emerges in human BM at 12 post conception weeks while fetal liver (FL) haematopoiesis is still expanding. Yet, almost nothing is known about how …

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Developmental cell programs are co-opted in inflammatory skin disease

Gary Reynolds, Péter Végh, James Fletcher, Elizabeth Poyner et autres

The skin confers biophysical and immunological protection through a complex cellular network established early in embryonic development. We profiled the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and …

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Automated, Miniaturized, and Scalable Screening of Healthcare Workers, First Responders, and Students for SARS-Cov-2 in San Diego County

Sydney Morgan, Stefan Aigner, Catelyn Anderson, Pedro Belda‐Ferre et autres

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Poised cell circuits in human skin are activated in disease

Gary Reynolds, Péter Végh, James Fletcher, Elizabeth Poyner et autres

Abstract The human skin confers biophysical and immunological protection through a complex cellular network that is established early in development. We profiled ~500,000 single cells using RNA-sequencing from healthy adult and developing skin, and skin from patients with atopic dermatitis and psoriasis. …

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A cell atlas of human thymic development defines T cell repertoire formation

Jong-Eun Park, Rachel A. Botting, Cecilia Domínguez Conde, Dorin-Mirel Popescu et autres

Thymus development, cell by cell The human thymus is the organ responsible for the maturation of many types of T cells, which are immune cells that protect us from infection. However, it is not well known how these cells develop with a …

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A cell atlas of human thymic development defines T cell repertoire formation

Jong-Eun Park, Rachel A. Botting, Cecilia Domínguez Conde, Dorin-Mirel Popescu et autres

Abstract The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We utilised single-cell RNA-sequencing (scRNA-seq) to create a cell census of the human thymus and to …

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