Kristaps Leškovskis

Bioinspired Energetic Materials: A Co‐Crystal of Explosophore‐Functionalized Nucleobase Analogs

Dāgs Dāvis Līpiņš, Elena Reinhardt, Thomas M. Klapoetke, Anatoly Mishnev et autres

A new class of bio-inspired insensitive energetic materials has been designed, synthesized, and comprehensively characterized. Co-crystal of 2,8-diazidoadenine and 8-nitrotetrazolo[1,5-c]pyrimidine-5,7(1H,6H)-dione was formed upon simple suspension in EtOAc. The crystalline phases were characterized by powder x-ray diffractograms, which unambiguously confirmed the formation of …

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Gut microbiome encoded purine and amino acid pathways present prospective biomarkers for predicting metformin therapy efficacy in newly diagnosed T2D patients

Ilze Elbere, Zigmunds Orlovskis, Laura Ansone, Ivars Silamiķelis et autres

Metformin is widely used for treating type 2 diabetes mellitus (T2D). However, the efficacy of metformin monotherapy is highly variable within the human population. Understanding the potential indirect or synergistic effects of metformin on gut microbiota composition and encoded functions could potentially …

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Annelētu azidopirimidīnu enerģētiskais profils un reakcijas ar nukleofīliem

Kristaps Leškovskis

Promocijas darbs sagatavots kā tematiski vienotu zinātnisko publikāciju kopa, kas ietver pētījumus par azidogrupas izmantošanu sintētiskajā metodoloģijā – reģioselektivitātes un reaģētspējas inducēšanai annelētos pirimidīnos – un materiālzinātnē – jaunu primāro sprāgstvielu izstrādē. Promocijas darbā apskatīti pirido[2,3-d]pirimidīni un pirido[3,2‑d]pirimidīni kā jauna tipa struktūras, …

CCDC 2208559: Experimental Crystal Structure Determination

Kristaps Leškovskis, Anatoly Mishnev, Irina Novosjolova, Māris Turks

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2208562: Experimental Crystal Structure Determination

Kristaps Leškovskis, Anatoly Mishnev, Irina Novosjolova, Māris Turks

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2208557: Experimental Crystal Structure Determination

Kristaps Leškovskis, Anatoly Mishnev, Irina Novosjolova, Māris Turks

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2208558: Experimental Crystal Structure Determination

Kristaps Leškovskis, Anatoly Mishnev, Irina Novosjolova, Māris Turks

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2208560: Experimental Crystal Structure Determination

Kristaps Leškovskis, Anatoly Mishnev, Irina Novosjolova, Māris Turks

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2208561: Experimental Crystal Structure Determination

Kristaps Leškovskis, Anatoly Mishnev, Irina Novosjolova, Māris Turks

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2208556: Experimental Crystal Structure Determination

Kristaps Leškovskis, Anatoly Mishnev, Irina Novosjolova, Māris Turks

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

CCDC 2257695: Experimental Crystal Structure Determination

Kristaps Leškovskis, Anatoly Mishnev, Irina Novosjolova, Burkhard Krumm et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

2,4,6,8-Tetraazidopyrimido[5,4- d ]pyrimidine: a novel energetic binary compound

Kristaps Leškovskis, Anatoly Mishnev, Irina Novosjolova, Burkhard Krumm et autres

The novel binary energetic compound C 6 N 16 is synthesized. Its chemical structure is fully characterized by NMR spectroscopy and X-ray analysis, and its energetic properties are determined by experimental and computational methods.

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