Gustavo Sevlever

Multidomain lifestyle intervention for the prevention of cognitive decline in at-risk older adults in Latin America (LatAm-FINGERS): a single-blind, multicentre, randomised controlled trial

Lucía Crivelli, Cláudia Kimie Suemoto, Ana Luisa Sosa, Francisco Lopera et autres

ar, us, mx, co, br, nl, uy, cl, do, cr, bo, pe, ec, pr, se (code pays fourni par la source)

Abstract 4784: Galectin-1 as a central regulator of angiogenesis and metabolic reprogramming in glioblastoma

Luisina Belén Ripari, Joaquín P. Merlo, Mariana Belén Vera, Olivia Morris-Hanon et autres

Abstract Glioblastoma (GB) is the most aggressive tumor of the central nervous system characterized by rapid growth and remarkable resistance to current therapies. Its biology is shaped by profound inter- and intra-tumoral heterogeneity, a highly immunosuppressive microenvironment, and a strong dependence on …

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A Decline in Metabotropic Glutamate mGlu3 Receptor Levels Is Associated With Amyloid Plaques in Alzheimer's Disease and Is Detectable in Serum During Mild Cognitive Impairment

Eugenia Olivera, Albany Sáez, Micaela Castro, Pilar Garaventa et autres

Subtype 3 metabotropic glutamate receptors (mGlu3R) play neuroprotective roles and are involved in superior executive functions and memory in humans. However, this target has been scarcely studied in the context of Alzheimer's disease (AD). Our previous results showed that astroglial mGlu3R promoted …

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Modulating SPARC Expression in Mesenchymal Stem Cells Improves Secretome-Mediated Skin Regeneration and Wound Repair

Antonella Lombardi, Joaquín Smucler, María Belén Palma, Ailén Iribarne et autres

ABSTRACT Mesenchymal stem cells (MSCs) have garnered significant attention over the past three decades due to their robust regenerative potential, primarily mediated by their paracrine activity by releasing soluble bioactive factors and extracellular vesicles (EVs). The MSC secretome plays a pivotal role …

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Generation of a human induced pluripotent stem cell line (FLENIi004-A) from an Autosomal-Dominant Alzheimer’s disease PSEN1 p.M146L patient

M. Vautier, Patricio Chrem Méndez, Guillermo Jerez Ferreyra, Victoria Massazza et autres

Human induced pluripotent stem cell (hiPSC) line FLENIi004-A was generated from peripheral blood mononuclear cells (PBMCs) using the lentiviral-hSTEMCCA-loxP vector. FLENIi004-A was derived from a 41-year-old Argentinean Caucasian male patient with Autosomal-Dominant Alzheimer's Disease, who carried the heterozygous PSEN1 p.M146L mutation. The …

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Frontotemporal dementia: Clinical aspects, genetics, and neuropathology of a family with a C9ORF72 expansion in Argentina

Karen Roman, Carolina Agatha Ardohain, Ezequiel Surace, Mónica B. Mezmezian et autres

Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia, typically manifesting before the age of 65, with a mean onset at 58 years. FTD may encompass a spectrum of neurodegenerative disorders resulting from frontotemporal lobar degeneration (FTLD), affecting behavior, …

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Recognition memory in individuals with mild cognitive impairment and Alzheimer’s dementia: a systematic review

María Julieta Russo, José Bueri, Lucía Alba‐Ferrara, E Labos et autres

BACKGROUND: Episodic memory impairment is a hallmark of Alzheimer's disease (AD) and is already present in its prodromal stage. While recall deficits are well established as predictors of memory performance, the role of recognition memory-particularly the dissociation between familiarity and recollection-remains less …

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Recognition memory in individuals with mild cognitive impairment and Alzheimer’s dementia: a systematic review

María Julieta Russo, José Bueri, Lucía Alba‐Ferrara, Edith Labos et autres

Episodic memory impairment is a hallmark of Alzheimer’s disease (AD) and is already present in its prodromal stage. While recall deficits are well established as predictors of memory performance, the role of recognition memory—particularly the dissociation between familiarity and recollection—remains less explored. …

Recognition memory in individuals with mild cognitive impairment and Alzheimer’s dementia: a systematic review

María Julieta Russo, José Bueri, Lucía Alba‐Ferrara, Edith Labos et autres

Episodic memory impairment is a hallmark of Alzheimer’s disease (AD) and is already present in its prodromal stage. While recall deficits are well established as predictors of memory performance, the role of recognition memory—particularly the dissociation between familiarity and recollection—remains less explored. …

Progressive Supranuclear Palsy associated with an SQSTM1/p62 variant: A clinicopathological study

Indiana Páez-Paz, Mariana Holubiec, Nahuel Fonseca, Mónica Mezmezian et autres

[Concussions in football: Recent advances and challenges in clinical and preventive management].

María Julieta Russo, Fernando Salvat, Sebastián Ameriso, Donato Villani et autres

Concussions in soccer are a key challenge for neurological health due to their high incidence, diagnostic complexity, and risk of long-term sequelae. This article provides a narrative review of their definition, epidemiology, pathophysiology, diagnosis, management, and prevention, integrating the most recent international …

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Novel in-frame variant in DES (p.Glu353dup) causes myofibrillar myopathy: clinical, in silico and functional studies

Sheila Lucía Castañeda, Guadalupe Amín, María Inés Freiberger, Federico Zabalegui et autres

BACKGROUND: Desmin (DES) is a major intermediate filament protein involved in the structural integrity and function of striated muscles. Pathogenic mutations in DES are predominantly missense variants, causing isolated cardiomyopathy and combinations of myopathy and cardiomyopathy. In-frame insertions are very rare and …

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