Butuo Li

Comparative safety of immune checkpoint inhibitor combined with chemotherapy as first-line treatment for solid tumors: a systematic review and network meta–analysis

Yiyue Xu, Butuo Li, Aiqin Gao, Qian Zhao et autres

Immune checkpoint inhibitors (ICIs) combined with chemotherapy have become standard first-line treatment for multiple solid tumors, yet their safety profiles vary across therapeutic agents and tumor types. This systematic review and network meta-analysis (NMA) compared the safety of ICI plus chemotherapy regimens …

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Deep Learning-Driven Anticancer Drug Discovery: Emodepside as a Potential Therapeutic Candidate for Triple-Negative Breast Cancer

Yiyue Xu, Taotao Dong, Butuo Li, Jinming Yu et autres

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with a poor prognosis. The absence of effective targeted therapies and endocrine treatment options leads to limited therapeutic options, which remains one of the major clinical challenges in TNBC management. Drug discovery …

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PD-1+CD8+ T cell infiltration complements PD-L1 to predict first-line chemo-immunotherapy outcomes in advanced ESCC

Qian Zhao, Shuping Cheng, Yiyu Meng, Butuo Li et autres

Only a subset of patients with esophageal squamous cell carcinoma (ESCC) benefits from first-line immunochemotherapy, and PD-L1 alone has limited predictive value, underscoring the need for complementary biomarkers. We analyzed pretreatment FFPE biopsies from 147 ESCC patients treated with PD-1 inhibitors plus …

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Comparative safety of immune checkpoint inhibitor–chemotherapy regimens across multiple tumor types: A systematic review and network meta-analysis.

Yiyue Xu, Butuo Li, Aiqin Gao, Qian Zhao et autres

e14571 Background: Immune checkpoint inhibitors (ICIs) combined with chemotherapy have become standard first-line treatment for multiple solid tumors, yet their safety profiles vary across therapeutic agents and tumor types. This systematic review and network meta-analysis (NMA) compared the safety of ICI plus …

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Impact of lymphatic ablation approaches on immunotherapy efficacy in advanced/metastatic esophageal squamous cell carcinoma: A multi‐institutional retrospective cohort study

Yingxin Liu, Butuo Li, Ziyi Wang, Shuqiao Zheng et autres

Immune checkpoint inhibitor (ICI)-based therapy is standard care for advanced or recurrent esophageal squamous cell carcinoma after radical treatment, yet the effect of prior lymphatic interventions on ICI efficacy remains unclear. Because tumor-draining lymph nodes serve as key hubs of anti-tumor immunity, …

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Combining evidence and practice: evaluating proton re-irradiation in recurrent lung cancer

Yingxin Liu, Junyi He, Butuo Li, Huiwen Alex Yang et autres

BACKGROUND: Locoregional recurrence of lung cancer after definitive radiotherapy remains a clinical challenge. Although re-irradiation offers curative potential, its application is limited by cumulative toxicity to organs at risk. Proton re-irradiation therapy (PRT) provides favorable dosimetric properties that may mitigate treatment-related adverse …

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Combining evidence and practice: evaluating proton re-irradiation in recurrent lung cancer

Yingxin Liu, Junyi He, Butuo Li, Yixuan Wang et autres

Locoregional recurrence of lung cancer after definitive radiotherapy remains a clinical challenge. Although re-irradiation offers curative potential, its application is limited by cumulative toxicity to organs at risk. Proton re-irradiation therapy (PRT) provides favorable dosimetric properties that may mitigate treatment-related adverse events …

Combining evidence and practice: evaluating proton re-irradiation in recurrent lung cancer

Yingxin Liu, Junyi He, Butuo Li, Yixuan Wang et autres

Locoregional recurrence of lung cancer after definitive radiotherapy remains a clinical challenge. Although re-irradiation offers curative potential, its application is limited by cumulative toxicity to organs at risk. Proton re-irradiation therapy (PRT) provides favorable dosimetric properties that may mitigate treatment-related adverse events …

Maximizing survival benefit with precision therapy based on progressive patterns after immunochemotherapy in metastatic esophageal cancer

Yingnan Liu, Shuping Cheng, Taotao Dong, Butuo Li et autres

< 0.002). Overall, RT is more important for patients with REO, while IO rechallenge could play a more dominant role for REP.

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Characteristics of Pharyngeal Foreign Bodies on Flexible Fiberoptic Endoscopy

Yongming Pan, Jing Li, Changzhen Wu, Ye Li et autres

OBJECTIVES: The inconspicuous location and nonspecific symptoms of pharyngeal foreign bodies (FBs) can lead to diagnostic challenges and suboptimal outcomes. This retrospective cohort study aimed to investigate the endoscopic characteristics of pharyngeal FBs to provide guidance for clinical diagnosis and management. METHODS: …

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Potential applications of metal-based nanomaterials in tumor radiotherapy: from x-ray to particle therapies

Yingxin Liu, Butuo Li, Linlin Wang

The integration of radiotherapy (RT) with nanotechnology has emerged as a promising strategy for enhancing cancer treatment efficacy. While RT remains a cornerstone in oncology, challenges such as tumor hypoxia, radioresistance, and off-target toxicity limit its therapeutic potential. Metal-based nanoparticles (MNPs), including …

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Deep learning for survival prediction in triple-negative breast cancer: development and validation in real-world cohorts

Yiyue Xu, Butuo Li, Bing Yu Zou, Bingjie Fan et autres

Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous disease, highlighting the need for better patient stratification to guide treatment. We developed a deep learning-based survival model and an individualized prognosis system using data from 37,818 TNBC patients in the SEER database …

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