Joseph M. Hwang

Adeno-associated virus gene therapy–mediated CCR5 blockade suppresses virus replication long term in SHIV-infected macaques

Helen L. Wu, Gabriela M. Webb, Sebastian P. Fuchs, Cleiton T. Pessoa et autres

Adeno-associated virus (AAV) vectors are promising vehicles for the delivery and long-term expression of antibodies for treatment of chronic diseases. Given the strong link between the C-C chemokine receptor 5 (CCR5)–Δ 32/ Δ 32 genotype and protection from HIV, we explored the …

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Abstract 1954: Spatial and single-cell DNA methylation analysis of primary breast cancer reveals lineage independent epigenetic plasticity.

Ruslan Strogantsev, Aysegul Ors, Jamie L. Endicott, Aaron Reid Doe et autres

Abstract Introduction: Intra-tumoral heterogeneity is governed by the interplay between rigid genetic evolution and plastic epigenetic states. However, dissecting the distinct contributions of these forces remains a challenge. While single-cell methods have traced genetic phylogeny, the spatial logic of epigenetic evolution and …

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Effect of metabolic status on response to SIV infection and antiretroviral therapy in nonhuman primates

Gabriela M. Webb, Kristin A. D. Sauter, Diana Lynn Takahashi, Melissa Ann Kirigiti et autres

Current antiretroviral therapy (ART) regimens efficiently limit HIV replication, thereby improving the life expectancy of people living with HIV; however, they also cause metabolic side effects. The ongoing obesity epidemic has resulted in more people with metabolic comorbidities at the time of …

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Immune restoration by TIGIT blockade is insufficient to control chronic SIV infection

Gabriela M. Webb, Cleiton T. Pessoa, Allyson J. McCullen, Joseph M. Hwang et autres

ABSTRACT TIGIT is a negative immune checkpoint receptor associated with T cell exhaustion in cancer and HIV. TIGIT upregulation in virus-specific CD8 + T cells and NK cells during HIV/SIV infection results in dysfunctional effector capabilities. In vitro studies targeting TIGIT on …

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Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques

Helen L. Wu, Kathleen Busman‐Sahay, Whitney C. Weber, Courtney M. Waytashek et autres

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Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species

Daniel Malouli, Roxanne M. Gilbride, Helen L. Wu, Joseph M. Hwang et autres

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Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species

Xiao Chang, Jason S. Reed, Gabriela M. Webb, Helen L. Wu et autres

The CCR5-specific antibody Leronlimab is being investigated as a novel immunotherapy that can suppress HIV replication with minimal side effects. Here we studied the virological and immunological consequences of Leronlimab in chronically CCR5-tropic HIV-1 infected humans (n = 5) on suppressive antiretroviral …

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CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab

Xiao Chang, Helen L. Wu, Gabriela M. Webb, Meenakshi Tiwary et autres

CCR5 plays a central role in infectious disease, host defense, and cancer progression, thereby making it an ideal target for therapeutic development. Notably, CCR5 is the major HIV entry co-receptor, where its surface density correlates with HIV plasma viremia. The level of …

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