Camille Noiray

Progression of fiber bundle damage in amnestic Alzheimer’s disease and LATE: a 2-year fixel-based study

Aurélie Lebrun, Yann Leprince, Pauline Olivieri, Martin Moussion et autres

Alzheimer's disease (AD) and limbic-predominant age-related TDP-43 encephalopathy (LATE) are two neurodegenerative diseases underpinned by distinct proteinopathies, which share a similar initial amnestic clinical phenotype but have a different clinical course. Some pathophysiological models suggest a role for white matter (WM) fiber …

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Progression of fiber bundle damage in amnestic Alzheimer’s disease and LATE: a 2-year fixel-based study

Aurélie Lebrun, Yann Leprince, Pauline Olivieri, Martin Moussion et autres

Abstract Alzheimer’s disease (AD) and limbic-predominant age-related TDP-43 encephalopathy (LATE) are two neurodegenerative diseases underpinned by distinct proteinopathies, which share a similar initial amnestic clinical phenotype but have a different clinical course. Some pathophysiological models suggest a role for white matter (WM) …

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How fiber bundle alterations differ in presumed LATE and amnestic Alzheimer's disease

Aurélie Lebrun, Yann Leprince, Julien Lagarde, Pauline Olivieri et autres

INTRODUCTION: Typical Alzheimer's disease (AD) and limbic-predominant age-related TAR DNA-binding protein 43 (TDP-43) encephalopathy (LATE) are two neurodegenerative diseases that present with a similar initial amnestic clinical phenotype but are associated with distinct proteinopathies. METHODS: We investigated white matter (WM) fiber bundle …

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Combined in vivo MRI assessment of locus coeruleus and nucleus basalis of Meynert integrity in amnestic Alzheimer’s disease, suspected-LATE and frontotemporal dementia

Julien Lagarde, Pauline Olivieri, Mattéo Tonietto, Camille Noiray et autres

BACKGROUND: The locus coeruleus (LC) and the nucleus basalis of Meynert (NBM) are altered in early stages of Alzheimer's disease (AD). Little is known about LC and NBM alteration in limbic-predominant age-related TDP-43 encephalopathy (LATE) and frontotemporal dementia (FTD). The aim of …

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Assessment of Mendelian and risk-factor genes in Alzheimer disease: A prospective nationwide clinical utility study and recommendations for genetic screening

Gaël Nicolas, Aline Zaréa, Morgane Lacour, Olivier Quenez et autres

PURPOSE: To assess the likely pathogenic/pathogenic (LP/P) variants rates in Mendelian dementia genes and the moderate-to-strong risk factors rates in patients with Alzheimer disease (AD). METHODS: We included 700 patients in a prospective study and performed exome sequencing. A panel of 28 …

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Hypersomnia and narcolepsy in 42 adult patients with craniopharyngioma

Pauline Dodet, Camille Noiray, Smaranda Leu‐Semenescu, Etienne Lefevre et autres

STUDY OBJECTIVES: To evaluate sleep, sleepiness, and excessive need for sleep in patients with craniopharyngioma (a suprasellar tumor which can affect sleep-wake systems). METHODS: A retrospective study of all adult patients living with craniopharyngioma referred to the sleep clinic, who received a …

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Penetrance estimation of Alzheimer disease in SORL1 loss-of-function variant carriers using a family-based strategy and stratification by APOE genotypes

Catherine Schramm, Camille Charbonnier, Aline Zaréa, Morgane Lacour et autres

BACKGROUND: Alzheimer disease (AD) is a common complex disorder with a high genetic component. Loss-of-function (LoF) SORL1 variants are one of the strongest AD genetic risk factors. Estimating their age-related penetrance is essential before putative use for genetic counseling or preventive trials. …

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Sweet or Bland Dreams? Taste Loss in Isolated REM ‐Sleep Behavior Disorder and Parkinson's Disease

Milan Nigam, Inès Ayadi, Camille Noiray, Ana Brás et autres

BACKGROUND: Hyposmia and isolated REM sleep behavior disorder are well-established features of prodromal Parkinson's disease (PD). OBJECTIVES: The objective of the present study was to evaluate whether taste loss (reported in PD and possibly suggesting brain stem involvement) is present at the …

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Alanyl-tRNA Synthetase 2-Related Dementia with Selective Bilateral Frontal Cystic Leukoencephalopathy

Guilhem Carle, Alexandre Morin, Camille Noiray, Perrine Roy-Joly et autres

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