Manuela Heßmann

Correction to “Isoindolinone-Based PET Tracers for Imaging Mutant Huntingtin Aggregates”

Longbin Liu, Peter Johnson, Matthew R. Mills, Penelope A. Turner et autres

Isoindolinone-Based PET Tracers for Imaging Mutant Huntingtin Aggregates

Longbin Liu, Peter Johnson, Matthew R. Mills, Penelope A. Turner et autres

Huntington’s disease (HD) is caused by the repeat expansion of the CAG trinucleotide in the mutant Huntingtin gene (m HTT ) within the exon1 region, resulting in an expanded polyglutamine-containing mHTT exon1 protein that serves as the source of the hallmark mHTT …

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Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates

Longbin Liu, Peter Johnson, Michael E. Prime, Vinod K. Khetarpal et autres

Therapeutic interventions are being developed for Huntington’s disease (HD), a hallmark of which is mutant huntingtin protein (mHTT) aggregates. Following the advancement to human testing of two [ 11 C]-PET ligands for aggregated mHTT, attributes for further optimization were identified. We replaced …

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Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s disease

Daniele Bertoglio, Jonathan Bard, Manuela Heßmann, Longbin Liu et autres

Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin ( HTT ) gene that encodes the pathologic mutant HTT (mHTT) protein with an expanded polyglutamine (polyQ) tract. Whereas several therapeutic programs targeting mHTT …

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Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates

Frank Herrmann, Manuela Heßmann, Sabine Schaertl, Karola Berg-Rosseburg et autres

Huntington's disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the huntingtin (HTT) gene coding for the huntingtin (HTT) protein. The misfolding and consequential aggregation of CAG-expanded mutant HTT (mHTT) underpin HD pathology. Our interest in …

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[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins

Longbin Liu, Peter Johnson, Michael E. Prime, Vinod K. Khetarpal et autres

The expanded polyglutamine-containing mutant huntingtin (mHTT) protein is implicated in neuronal degeneration of medium spiny neurons in Huntington’s disease (HD) for which multiple therapeutic approaches are currently being evaluated to eliminate or reduce mHTT. Development of effective and orthogonal biomarkers will ensure …

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A novel imaging ligand as a biomarker for mutant huntingtin-lowering in Huntington’s disease

Daniele Bertoglio, Jonathan Bard, Manuela Heßmann, Longbin Liu et autres

Abstract Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin ( HTT ) gene that encodes the pathologic mutant HTT (mHTT) protein with an expanded polyglutamine (PolyQ) tract. While several therapeutic programs targeting …

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Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand

Longbin Liu, Michael E. Prime, Matt R. Lee, Vinod K. Khetarpal et autres

Abstract Mutant huntingtin (mHTT) protein carrying the elongated N-terminal polyglutamine (polyQ) tract misfolds and forms protein aggregates characteristic of Huntington’s disease (HD) pathology. A high-affinity ligand specific for mHTT aggregates could serve as a positron emission tomography (PET) imaging biomarker for HD …

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Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis

Erik Schmok, Mahin Abad Dar, Jochen Behrends, Hanna Erdmann et autres

Suppressor of cytokine signaling 3 (SOCS3) is a feedback inhibitor of interleukin (IL)-6 signaling in macrophages. In the absence of this molecule, macrophages become extremely prone to an IL-6-dependent expression of arginase-1 (Arg1) and nitric oxide synthase (NOS)2, the prototype markers for …

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SOCS3 in macrophages prevents exacerbated IL-6-dependent arginase-1 activity and early permissiveness to experimental tuberculosis

Erik Schmok, Mahin Abad Dar, Jochen Behrends, Hanna Erdmann et autres

Efficacy of drugs used in the treatment of IBD and combinations thereof in acute DSS-induced colitis in mice

Holger Sann, Jasmin von Erichsen, Manuela Heßmann, Andreas Pahl et autres

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DAP10 contributes to CD8+ T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection

Manuela Heßmann, Alexandra Rausch, Dominik Rückerl, Pamela Scott Adams et autres

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