Pilar Dongil

Onion and Apple Functional Ingredients Intake Improves Antioxidant and Inflammatory Status and Vascular Injury in Obese Zucker Rats

Claudia Balderas, Javier Angulo, Alejandro Sevilleja-Ortiz, Concepción Peiró et autres

The objective of this study was to investigate the effects of onion and apple functional ingredients in homozygous (fa/fa) obese Zucker rats. Rodents were fed three diets: standard diet [obese control (OC) group], standard diet containing 10% onion [obese onion 10% (OO) …

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Resolvin E1 attenuates endothelial senescence induced by doxorubicin through the modulation of NLRP3 inflammasome activation.

Licia Shamoon, Jenaro Espitia-Corredor, Pilar Dongil, Marta Menéndez-Ribes et autres

Introduction: Vascular aging is associated with endothelial cell senescence, favoring low-grade inflammation, endothelial dysfunction, and cardiovascular diseases. Cell senescence arises from a wide variety of endogenous and exogenous stressors including some anticancer agents such as doxorubicin. Recently, doxorubicin was linked to the …

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Resolvin E1 attenuates doxorubicin-induced endothelial senescence by modulating NLRP3 inflammasome activation

Licia Shamoon, Jenaro Espitia-Corredor, Pilar Dongil, Marta Menéndez-Ribes et autres

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DPP4 Promotes Human Endothelial Cell Senescence and Dysfunction via the PAR2–COX-2–TP Axis and NLRP3 Inflammasome Activation

Inés Valencia, Susana Vallejo, Pilar Dongil, Alejandra Romero et autres

BACKGROUND: Abnormal accumulation of senescent cells in the vessel wall leads to a compromised vascular function contributing to vascular aging. Soluble DPP4 (dipeptidyl peptidase 4; sDPP4) secretion from visceral adipose tissue is enhanced in obesity, now considered a progeric condition. sDPP4 triggers …

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Pharmacological Blockade of NLRP3 Inflammasome/IL-1β-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction

Alejandra Romero, Pilar Dongil, Inés Valencia, Susana Vallejo et autres

The clinical relevance of IL-1β in chronic inflammation underlying atherosclerosis has been reinforced by recent evidence associating pharmacological inhibition of the cytokine with lower cardiovascular risk. Previously, we have demonstrated a direct involvement of IL-1β in endothelial senescence. Therefore, this can be …

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Preventing Oxidative Stress in the Liver: An Opportunity for GLP-1 and/or PASK

Verónica Hurtado-Carneiro, Pilar Dongil, Ana Pérez-García, Elvira Álvarez et autres

The liver's high metabolic activity and detoxification functions generate reactive oxygen species, mainly through oxidative phosphorylation in the mitochondria of hepatocytes. In contrast, it also has a potent antioxidant mechanism for counterbalancing the oxidant's effect and relieving oxidative stress. PAS kinase (PASK) …

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Storage and Utilization of Glycogen by Mouse Liver during Adaptation to Nutritional Changes Are GLP-1 and PASK Dependent

Ana Pérez-García, Verónica Hurtado-Carneiro, Carmen M. Herrero-de-Dios, Pilar Dongil et autres

Glucagon-like peptide 1 (GLP-1) and PAS kinase (PASK) control glucose and energy homeostasis according to nutritional status. Thus, both glucose availability and GLP-1 lead to hepatic glycogen synthesis or degradation. We used a murine model to discover whether PASK mediates the effect …

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Soluble dipeptidyl peptidase 4 (sDPP4) as inducer of vascular inflammaging: a role for NLRP3 inflammasome.

Inés Valencia, Pilar Dongil, Susana Vallejo, Alejandra Méndèz Romero et autres

PAS kinase deficiency reduces aging effects in mice

Pilar Dongil, Ana Pérez-García, Verónica Hurtado-Carneiro, Carmen M. Herrero-de-Dios et autres

, and maintained elevated PCNA protein, suggesting that hepatic cell repair mechanisms might be functional. PASK-deficient mice have better insulin sensitivity and no glucose intolerance, as confirmed by a normal HOMA-IR index. PASK may be a good target for reducing damage during …

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PK-profiling method for identifying the expression of resistance-associated genes in partially resistant oats to crown rust

Yolanda Loarce, Pilar Dongil, A. Fominaya, Juan Manuel González Gonzalez et autres

BACKGROUND: Protein kinases play a key role in plant cell homeostasis and the activation of defense mechanisms. Partial resistance to fungi in plants is interesting because of its durability. However, the variable number of minor loci associated with this type of resistance …

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Pas Kinase Deficiency Triggers Antioxidant Mechanisms in the Liver

Pilar Dongil, Ana Pérez-García, Verónica Hurtado-Carneiro, Carmen M. Herrero-de-Dios et autres

Metabolic dysfunction in the liver is the cause of numerous pathologies, which are associated with an altered redox state. PASK (PAS Domain Kinase) is a nutrient and bioenergetic sensor. We contend that PASK could act as an oxidative stress sensor in liver …

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PAS Kinase deficiency alters the glucokinase function and hepatic metabolism

Ana Pérez-García, Pilar Dongil, Verónica Hurtado-Carneiro, Enrique Blázquez et autres

The liver controls metabolic homeostasis in response to fasting and refeeding periods. Glucokinase (GCK) adjusts hepatic glucose phosphorylation to blood glucose levels, acting as a glucose sensor. Our objective was to determine whether PAS kinase (PASK), a nutrient sensor, could be affecting …

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