Steven Chun-Min Shih

Do chip mutations predict frailty and toxicity in transplant-eligible patients with multiple myeloma?

Steven Chun-Min Shih, Harjot Singh Vohra, Sahar Khan, Salman Basrai et autres

Abstract Background We have previously reported that current frailty tools have limited ability to predict treatment-related toxicity in transplant-eligible (TE) patients with multiple myeloma (MM) (Devasia, ASH 2022). Although clonal hematopoiesis of indeterminate potential (CHIP) mutations has been associated with more frailty …

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Operationalising Patient Selection for Outpatient Transplant in Multiple Myeloma: Subjective Versus Objective Measures

Steven Chun-Min Shih, Harjot Singh Vohra, Anup Joseph Devasia, Sahar Khan et autres

Minimal Residual Disease Testing Infrastructure in Multiple Myeloma: Guidance for Clinical Trial and Routine Practice Use in Canada

Hira S. Mian, Alissa Visram, Steven Chun-Min Shih, Suzanne Trudel et autres

Measurable/minimal residual disease (MRD) is 1 of the most powerful prognostic factors for progression-free survival and overall survival in multiple myeloma (MM) and may guide therapeutic approaches. Here, we provide an overview of the current state of MRD testing in MM in …

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Treatment of elderly and frail myeloma patients

Steven Chun-Min Shih, Alissa Visram, Hira S. Mian

Multiple myeloma (MM) is an incurable cancer of older adults. Given the aging population, the prevalence of older adults with MM is expected to further increase over the next decade. Challenges in treating older adults result from the heterogeneity of both aging …

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Review of CAR T-Cell Therapy in Multiple Myeloma: A Canadian Perspective

Steven Chun-Min Shih, Sita Bhella

Multiple myeloma (MM) is an incurable plasma cell malignancy. In the context of the current standard of care therapies in Canada, outcomes among patients with relapsed/refractory multiple myeloma (RRMM), particularly those with triple-class (or more) refractory disease remain poor. Immunotherapies have significantly …

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A +220 GATA motif mediates basal but not endotoxin-repressible expression of the von Willebrand factor promoter in Hprt-targeted transgenic mice

Ju Liu, Yasuharu Kanki, Yoshiaki Okada, EonSeon Jin et autres

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Supplementary Material for: Skin Biopsies Demonstrate Site-Specific Endothelial Activation in Mouse Models of Sepsis

Nathan Ivan Shapiro, Kimihiko Yano, Midori Sorasaki, C. Fischer et autres

Background/Aims: Skin biopsies allow for direct phenotyping of the endothelium in clinical settings. Objectives: We hypothesize that in murine sepsis endothelial activation is manifested by changes in protein and mRNA expression in skin biopsies, and that such alterations differ from other organs. …

Lobulated colonic lipoma mimicking carcinoma with intermittent intussusception

I-Chun Lin, Wei-Chin Chang, Tzu-Chao Hsu, Steven Chun-Min Shih et autres

Lipomas are the most common nonepithelial tumors of the colon, and rank third in frequency among benign colonic tumors after hyperplastic and adenomatous polyps [ 1 ]. Symptomatic colonic lipomas are uncommon, accounting for 6 % in clinical series at the Mayo …

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