Leo Nicolai

Splenic regulation of systemic platelet activation state

Lisa Laun, Alexander Leunig, Felix Zhang, Sezer Akgöl et autres

Platelets are essential to prevent blood loss and to orchestrate inflammation. Thrombotic complications of vascular disease and hyperresponsive platelets are associated with adverse outcomes, yet physiological mechanisms counteracting systemic platelet activation are poorly defined. In mice, we found that the spleen filters …

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Procoagulant platelets in haemostasis and thrombosis

Siyu Sun, Rainer Kaiser, Johan W.M. Heemskerk, Leo Nicolai

Procoagulant platelets are characterized by sustained high cytosolic Ca2+, surface exposure of phosphatidylserine (PS) and P-selectin, and a balloon-shaped morphological transformation. These features strongly facilitate the generation of coagulation factor Xa and thrombin on the platelet membrane. Here, we provide a referenced …

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Blocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA

Gemma Llovera, Steffanie Heindl, Dániel Péter Varga, Nikolett Lénárt et autres

Our research presents a new animal model of transient ischemic attack (TIA) that mimics brief episodes without cell loss, but results in neuronal and behavioral deficits. We identified excessive microglial reactivity, driven by acute ATP release, as a key factor in post-TIA …

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Platelet effector functions in inflammation

Raphael Escaig, Lennart Kreutz, Rainer Kaiser, Leo Nicolai

A State of the Art lecture titled "Platelet effector functions in inflammation" was presented at the International Society on Thrombosis and Haemostasis congress in 2025. It is increasingly recognized that platelets are critical orchestrators of innate and adaptive immune responses. In this …

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Procoagulant platelets: linking coagulation and thromboinflammation in cardiovascular disease

Rainer Kaiser, Leo Nicolai

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Thrombosis magnified—zooming in to get to the bottom of clot formation

Leo Nicolai

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Platelet heterogeneity in disease: the many and the diverse?

Rainer Kaiser, Afra Anjum, Leo Nicolai

ABSTRACT: Platelets in peripheral blood critically drive clot formation in health and disease. Previously considered to uniformly respond to vascular injury and inflammatory cues, recent studies have highlighted that circulating platelets exhibit marked heterogeneity, with distinct populations contributing differentially to hemostasis, thrombosis, …

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Reticulated platelets in coronary artery disease: a multidimensional approach unveils prothrombotic signalling and novel therapeutic targets

Kilian Kirmes, Jiaying Han, Melissa Klug, Conor J. Bloxham et autres

BACKGROUND AND AIMS: Reticulated platelets (RPs), hyperreactive and RNA-rich, are associated with increased risk of cardiovascular events and suboptimal response to antiplatelet therapy in coronary artery disease (CAD). However, the underlying mechanisms remain poorly defined. This study aimed to characterize the molecular …

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Platelets in vascular inflammation: fire-fighters or pyromaniacs?

Yacine Boulaftali, Steffen Maßberg, Leo Nicolai

PURPOSE OF REVIEW: In this review, we aim to highlight recent insights into the mechanisms through which platelets contribute to vascular inflammation. We will discuss how platelets interact with other cellular players in the vascular milieu, their role in shaping inflammatory responses, …

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Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution

Kami Pekayvaz, Badr Kilani, Markus Joppich, Luke Eivers et autres

phenotype. This immunothrombolytic axis results in thrombus resolution. Together, with this immune landscape of thrombosis, we provide a valuable resource and introduce the concept of "immunothrombolysis" with broad mechanistic and translational implications at the crossroad of inflammation and thrombosis.

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Platelet-activating histone/antihistone IgG complexes in anti-PF4–negative thrombosis and thrombocytopenia syndrome

Max Esefeld, Stefan Handtke, Rainer Kaiser, Leo Nicolai et autres

ABSTRACT: Thrombosis and thrombocytopenia syndromes (TTS) describe immune-mediated thrombotic adverse reactions after vaccination against COVID-19. Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a well-known subentity of TTS, caused by adenovirus vector-based vaccines. VITT is mediated by anti-platelet factor 4 (PF4) immunoglobulin G (IgG) …

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Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma

Adrian Gottschlich, Ruth Grünmeier, Gordon Victor Hoffmann, Sayantan Nandi et autres

ABSTRACT: The success of targeted therapies for hematological malignancies has heralded their potential as both salvage treatment and early treatment lines, reducing the need for high-dose, intensive, and often toxic chemotherapeutic regimens. For young patients with classic Hodgkin lymphoma (cHL), immunotherapies provide …

de, no, nl, fr (code pays fourni par la source)