Erica Villegas

Author Correction: A combined risk score enhances prediction of type 1 diabetes among susceptible children

Lauric A. Ferrat, Kendra Vehik, Seth A. Sharp, Åke Lernmark et autres

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Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes

Ingrid Brænne, Suna Önengüt-Gümüşcü, Ruoxi Chen, Ani W Manichaikul et autres

Significant progress has been made in elucidating genetic risk factors influencing Type 1 diabetes (T1D); however, features other than genetic variants that initiate and/or accelerate islet autoimmunity that lead to the development of clinical T1D remain largely unknown. We hypothesized that genetic …

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An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood

Ezio E. Bonifacio, Andreas Weiß, Christiane Winkler, Markus Hippich et autres

OBJECTIVE Islet autoimmunity develops before clinical type 1 diabetes and includes multiple and single autoantibody phenotypes. The objective was to determine age-related risks of islet autoantibodies that reflect etiology and improve screening for presymptomatic type 1 diabetes. RESEARCH DESIGN AND METHODS The …

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Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity

Sari Niinistö, Iris Erlund, Hye‐Seung Lee, Ulla M. Uusitalo et autres

Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type …

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A combined risk score enhances prediction of type 1 diabetes among susceptible children

Lauric A. Ferrat, Kendra Vehik, Seth A. Sharp, Åke Lernmark et autres

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Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study

Kendra Vehik, Ezio E. Bonifacio, Åke Lernmark, Liping Yu et autres

OBJECTIVE The first-appearing β-cell autoantibody has been shown to influence risk of type 1 diabetes (T1D). Here, we assessed the risk of autoantibody spreading to the second-appearing autoantibody and further progression to clinical disease in The Environmental Determinants of Diabetes in the …

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Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study

Qian Li, Hemang M. Parikh, Martha D. Butterworth, Åke Lernmark et autres

Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) at a very young age. Metabolic profile changes over time may imply responses to exposures and signal development of the first IA. Our …

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Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study

Xiang Liu, Kendra Vehik, Yangxin Huang, Helena Elding Larsson et autres

OBJECTIVE: This study investigates two-phase growth patterns in early life and their association with development of islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: The Environmental Determinants of Diabetes in the Young (TEDDY) study followed 7,522 genetically high-risk …

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Serum and Muscle Levels of alpha-Tocopherol, Ascorbic Acid, and Retinol Are Normal in Chronic Alcoholic Myopathy

J. Fern ndez-Sol, Erica Villegas, J. M. Nicol s, R. Deulofeu et autres

Some authors have suggested a possible loss of antioxidant factors in alcoholic skeletal myopathy. To assess the relationship between ethanol consumption and serum and muscle levels of α-tocopherol, ascorbic acid, and retinol in chronic alcoholics with and without skeletal myopathy, a prospective …

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