Sandrine Giscard d’Estaing

Lifetime occupational and para-occupational exposure to organic solvents and testicular germ cell tumor risk: a French case–control study—TESTIS

Margot Guth, Marie A. Lefèvre, Astrid Coste, Delphine Praud et autres

BACKGROUND: Despite an incidence increase in recent decades, the etiology of testicular germ cell tumors (TGCT) remains poorly understood. The hypothesis of a two-stage development, combining initial alteration in utero followed by malignant transformation later in life, has been suggested. This study …

fr, us (code pays fourni par la source)

COVID‐19 and Oncofertility: No SARS‐CoV‐2 in Semen but Inflammation Seems to Affect Sperm Parameters

Laure Chaput, Hanae Pons‐Rejraji, Hélène Chabrolles, Mélanie Fiot et autres

The COVID-19 pandemic, driven by SARS-CoV-2, led authorities to recommend halting assisted reproductive technology programs, focusing instead on fertility preservation, for cancer patients. The presence of SARS-CoV-2 in semen remains controversial. This multicentric prospective cohort study, conducted across 12 university medical centers, …

fr (code pays fourni par la source)

ICSI using testicular spermatozoa after failure of ICSI with ejaculated spermatozoa could be a good choice: A propensity score‐matched cohort study

Mehdi Benchaïb, Elsa Labrune, Sandrine Giscard d’Estaing, Cynthia Jovet et autres

BACKGROUND: Ejaculated spermatozoa are considered to possess a higher fertilisation potential than testicular spermatozoa. In selected cases, the use of testicular spermatozoa from non-azoospermic infertile men resulted in a higher implantation and pregnancy rate than the use of ejaculated spermatozoa. OBJECTIVE: The …

fr (code pays fourni par la source)

Impact of low- or moderate-risk gonadotoxic chemotherapy prior to testicular tissue freezing on spermatogonia quantity in human (pre)pubertal testicular tissue

Aurélie Rives‐Feraille, Agnès Liard, Nathalie Rives, Michaël Bubenheim et autres

STUDY QUESTION: What is the impact of low- or moderate-risk gonadotoxic chemotherapy received prior to testicular tissue freezing (TTF), and of the cancer itself, on spermatogonia quantity in testicular tissue from (pre)pubertal boys? SUMMARY ANSWER: Vincristine, when associated with alkylating agents, has …

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Case Report: Longitudinal follow-up and testicular sperm extraction in a patient with a pathogenic NR5A1 (SF-1) frameshift variant: p.(Phe70Serfs*5)

Jordan Teoli, Delphine Mallet, Lucie Renault, Claire-Lise Gay et autres

Background Steroidogenic factor 1 (SF-1), encoded by the nuclear receptor subfamily 5 group A member 1 (NR5A1) gene, is a transcriptional factor crucial for adrenal and gonadal organogenesis. Pathogenic variants of NR5A1 are responsible for a wide spectrum of phenotypes with autosomal …

fr (code pays fourni par la source)

Testicular germ cell tumour risk by occupation and industry: a French case–control study – TESTIS

Margot Guth, Astrid Coste, Marie Lefèvre, Floriane Deygas et autres

Objective Testicular germ cell tumours (TGCT) are the most common cancer in men of working age and its incidence has increased notably over the past 40 years. Several occupations have been identified as potentially associated with TGCT risk. The aim of this …

fr, us, ch, pk (code pays fourni par la source)

Delaying testicular sperm extraction in 47,XXY Klinefelter patients does not impair the sperm retrieval rate, and AMH levels are higher when TESE is positive

Lucie Renault, Elsa Labrune, Sandrine Giscard d’Estaing, Béatrice Cuzin et autres

STUDY QUESTION: Should testicular sperm extraction (TESE) in non-mosaic 47,XXY Klinefelter syndrome (KS) patients be performed soon after puberty or could it be delayed until adulthood? SUMMARY ANSWER: The difference in sperm retrieval rate (SRR) in TESE was not significant between the …

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What should be done in terms of fertility preservation for patients with cancer? The French 2021 guidelines

Nathalie Rives, Blandine Courbière, Thierry Almont, Diana Kassab et autres

AIM: To provide practice guidelines about fertility preservation (FP) in oncology. METHODS: We selected 400 articles after a PubMed review of the literature (1987-2019). RECOMMENDATIONS: Any child, adolescent and adult of reproductive age should be informed about the risk of treatment gonadotoxicity. …

fr, mq (code pays fourni par la source)

P-013 Testicular spermatozoa for intra-cytoplasmic sperm injection after IVF failure with ejaculated spermatozoa: a propensity score-matched cohort study

M Benchaib, Gaëlle Soignon, Elsa Labrune, P Jaeger et autres

Abstract Study question Does the use of testicular spermatozoa from non-azoospermic infertile men after failed IVF with ejaculated spermatozoa increases the pregnancy rate? Summary answer Depending on semen characteristics and obtained embryos number at the previous IVF failure with ejaculated spermatozoa, it …

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Fertility in men with Klinefelter's syndrome

Ingrid Plotton, Lucie Renault, Marion Lapoirie, Damien Sanlaville et autres

fr (code pays fourni par la source)

Effect of Recombinant Gonadotropin on Testicular Function and Testicular Sperm Extraction in Five Cases of NR0B1 (DAX1) Pathogenic Variants

Jordan Teoli, Vincent Mezzarobba, Lucie Renault, Delphine Mallet et autres

Background NR0B1 pathogenic variants can cause congenital adrenal hypoplasia or primary adrenal insufficiency in early childhood usually associated with hypogonadotropic hypogonadism. NR0B1 is necessary for organogenesis of the adrenal cortex and to maintain normal spermatogenesis. In humans, restoration of fertility in patients …

fr (code pays fourni par la source)

Shallow artificial networks with morphokinetic time‐lapse parameters coupled to ART data allow to predict live birth

Mehdi Benchaïb, Elsa Labrune, Sandrine Giscard d’Estaing, Bruno Salle et autres

Purpose: The purpose of this work was to construct shallow neural networks (SNN) using time-lapse technology (TLT) from morphokinetic parameters coupled to assisted reproductive technology (ART) parameters in order to assist the choice of embryo(s) to be transferred with the highest probability …

fr (code pays fourni par la source)