Marta Puerto

FRI-442 Stage-dependent central and peripheral dysregulation of platelet biogenesis in experimental cirrhosis

Carolina Franco, Iris Asensio, Marta Puerto, Elena Vázquez-Ogando et autres

SAT-350 Liver atrophy drives transcriptomic reprogramming of extrahepatic organs in experimental cirrhosis

Javier Vaquero, Iris Asensio, Marta Puerto, Carolina Franco et autres

Canola Meal in Poultry Diet: Impact on pH, Color, Drip Loss, Nutritional Composition and Oxidative Status of Fresh and Stored Meat

Marta Puerto, M.C. Cabrera, Ayrton da Silva, Roberto Olivero et autres

Canola meal, with environmentally friendly attributes, lower cost, and previous studies, is an interesting proteic source to partially replace the soybean meal for poultry nutrition. For that, in this work we aimed to investigate canola meal as a partial replacement of soybean …

uy (code pays fourni par la source)

Mesenteric Adipose Tissue Volume Predicts Response to Antitumor Necrosis Factor Therapy in Biological-Naïve Patients With Crohn's Disease

Helena Martínez-Lozano, Javier Martinez-Ollero, Carlos Iniesta, José C. Garrido-Bermejo et autres

INTRODUCTION: Crohn's disease is associated with varying degrees of mesenteric adipose tissue (MAT) hypertrophy. The study aimed to evaluate whether MAT hypertrophy, measured by MAT volume, is associated with worse response to anti-tumor necrosis factor alpha (TNF-α) therapy in biologic-naïve patients with …

es (code pays fourni par la source)

EXTRACELLULAR VESICLE PROFILING IN SEVERE COVID-19 RELATED ARDS: THE IMPACT OF CHRONIC LIVER DISEASE

José Luis Román, Mireya Montero, Antonio J. Ferruelo, Raquel Murillo et autres

Chronic liver disease (CLD) increases the risk of acute respiratory distress syndrome (ARDS). Extracellular vesicles (EVs) and their microRNA (EV-miRNA) cargo mediate liver–lung interaction, but their role in ARDS remains unclear. 1) To characterize EV-miRNA profiles in critically ill patients with COVID-19 …

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37 - THE PERIPHERAL AND CENTRAL DETERMINANTS OF PLATELET PRODUCTION SHOW DYNAMIC, STAGE-DEPENDENT ALTERATIONS IN EXPERIMENTAL CIRRHOSIS

Carolina Franco Herrera, Iris Asensio, Marta Puerto, Elena Vázquez-Ogando et autres

40 - DEVELOPMENT OF LIVER ATROPHY RESHAPES THE TRANSCRIPTOMIC PROFILES OF EXTRAHEPATIC ORGANS IN EXPERIMENTAL CIRRHOSIS

Javier Vaquero, Iris Asensio, Marta Puerto, Elena Vázquez-Ogando et autres

A single-nucleus multimodal framework reveals epigenomic priming of chemoresistant states in ovarian cancer

Yuna Landais, Juliette Bertorello, Marta Puerto, Amélie Roehrig et autres

Abstract Non-genetic intratumor heterogeneity (ITH) drives therapeutic failure in cancer, yet its clinical monitoring remains challenging. We develop a multimodal single-nucleus framework that simultaneously profiles transcriptional and histone modification landscapes from frozen biopsies. Applied to longitudinal samples from 16 patients with high-grade …

fr (code pays fourni par la source)

128O Evolution of transcriptomic and epigenomic intra-tumor heterogeneity in high-grade serous ovarian cancer with chemotherapy

Yuna Landais, Juliette Bertorello, Marta Puerto, Brett A. Simon et autres

Background: Tumor-infiltrating lymphocyte (TIL) therapy can elicit durable responses in advanced cancers.While it is established that response to TIL therapy relies in large part on the activity of CD8 + T cells, the intratumoral CD8 + T cell states that determine clinical …

fr (code pays fourni par la source)

Abstract 1252: Evolution of transcriptomic and epigenomic intra-tumor heterogeneity in high-grade serous ovarian cancer with chemotherapy

Yuna Landais, Juliette Bertorello, Marta Puerto, Amélie Roehrig et autres

Background: Intra-tumor heterogeneity (ITH) refers to the presence of diverse cell populations within a single tumor, each with distinct genetic, epigenetic, and phenotypic characteristics. This complexity presents significant challenges in treatment, as different subpopulations may respond variably to therapies, yet the non-genetic …

fr, us (code pays fourni par la source)

Vitamin D Supplementation Is Associated with Inflammation Amelioration and Cognitive Improvement in Decompensated Patients with Cirrhosis

Raquel Diaz-Ruiz, María Poca, Eva María Román, Rocío Panadero et autres

Background/Objectives: Decompensated cirrhosis is characterized by systemic inflammation and innate and adaptive immune dysfunction. Hepatic encephalopathy (HE) is a prevalent and debilitating condition characterized by cognitive disturbances in which ammonia and inflammation play a synergistic pathogenic role. Extraskeletal functions of vitamin D …

es, au (code pays fourni par la source)

The zinc-finger protein Z4 cooperates with condensin II to regulate somatic chromosome pairing and 3D chromatin organization

Marta Puerto, Mamta Shukla, Paula Bujosa, Juan Pérez-Roldán et autres

Chromosome pairing constitutes an important level of genome organization, yet the mechanisms that regulate pairing in somatic cells and the impact on 3D chromatin organization are still poorly understood. Here, we address these questions in Drosophila, an organism with robust somatic pairing. …

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