Dmitry Alexeev

Operational numerical weather prediction with ICON on GPUs (version 2024.10)

Xavier Lapillonne, Daniel Hupp, Fabian Gessler, André Walser et autres

Abstract. Numerical weather prediction and climate models require continuous adaptation to take advantage of advances in high-performance computing hardware. This paper presents the port of the ICON model to GPUs using OpenACC compiler directives for numerical weather prediction applications. In the context …

ch, us, de (code pays fourni par la source)

New trends in non-surgical treatment of osteoarthritis. Short review

Anzhela Sergeevna Mulyk, Dmitry Alexeev, A. A. Akulaev, А. В. Губин

At least 240 million people worldwide have symptomatic osteoarthritis and its prevalence is increasing. Current protocols for non-surgical treatment are very limited, and the number of surgical interventions on joints is increasing. Given the global prevalence of this disease, an effective disease-modifying …

ru, es (code pays fourni par la source)

Translation dysregulation in cancer as a source for targetable antigens

Chen Weller, Osnat Bartok, Christopher S. McGinnis, Heyilimu Palashati et autres

Aberrant peptides presented by major histocompatibility complex (MHC) molecules are targets for tumor eradication, as these peptides can be recognized as foreign by T cells. Protein synthesis in malignant cells is dysregulated, which may result in the generation and presentation of aberrant …

il, us, no, jp, de, gb (code pays fourni par la source)

Smart spaces and ensuring their information security

В.Н. Шведенко, O. V. Shchekochikhin, Dmitry Alexeev

ru, us (code pays fourni par la source)

ICON NWP on GPUs

Marek Jacob, Dmitry Alexeev, Remo Dietlicher, Victoria Cherkas et autres

Weather prediction centers are always looking for the best computational performance for their numerical weather prediction (NWP) model, given their financial budget. Over the last decades, most centers relied on computer systems with scalar x86 architectures. This, however, might not be the …

de, gb, ch (code pays fourni par la source)

Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone

Alina D. Nikotina, Snezhana A. Vladimirova, Elena Y. Komarova, Dmitry Alexeev et autres

Hyperglycemia may contribute to the progression of carcinomas by triggering epithelial-to-mesenchymal transition (EMT). Some proteostasis systems are involved in metastasis; in this paper, we sought to explore the mechanism of Hsp70 chaperone in EMT. We showed that knockdown of Hsp70 reduced cell …

ru (code pays fourni par la source)

Yogurt fortified with vitamins and probiotics impacts the frequency of upper respiratory tract infections but not gut microbiome: A multicenter double-blind placebo controlled randomized study

Vera Odintsova, Natalia Klimenko, Alexander Tyakht, Olesya Volokh et autres

Probiotics and vitamins can impact immune responses and modulate gut microbiome. We evaluated the effects of consuming a yogurt fortified with vitamins and probiotic Lacticaseibacillus casei and rhamnosus on upper respiratory tract infections frequency and gut microbiome during a 3-month intervention. The …

ru (code pays fourni par la source)

Temporal dynamics of probiotic Lacticaseibacillus casei and rhamnosus abundance in a fermented dairy product evaluated using a combination of cultivation-dependent and -independent methods

Yulia Berezhnaya, Irina Bikaeva, Anastasiia Gachkovskaia, А. В. Демиденко et autres

ru (code pays fourni par la source)

Two-Element Keyboard-Block Model Of Megathrust Earthquakes Generation For Central Kurils

Yu. V. Gabsatarov, I. S. Vladimirova, Dmitry Alexeev, L. I. Lobkovsky

The strongest subduction earthquakes (M≥8) lead to the release of the huge amount of elastic stresses accumulated over hundreds or even thousands of years. Prediction of such earthquakes, causing significant socio-economic and environmental damage, is one of the most important and urgent …

ru (code pays fourni par la source)

Gut microbiome signature of Viliuisk encephalomyelitis in Yakuts includes an increase in microbes linked to lean body mass and eating behaviour

Veronika Kuznetsova, Alexander Tyakht, Lyudmila V. Akhmadishina, Vera Odintsova et autres

BACKGROUND: Viliuisk encephalomyelitis (VE) is a rare endemic neurodegenerative disease occurring in the Yakut population of Northeastern Siberia. The main clinical features of VE are spasticity, dysarthria, dementia, central paresis and paralysis, and cortical atrophy observed via MRI. Many hypotheses have been …

ru, gb, au (code pays fourni par la source)

Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies

Alexandra S. Shadrina, Tatiana Shashkova, Anna A. Torgasheva, Sodbo Sharapov et autres

Genome-wide association studies have led to a significant progress in identification of genomic loci affecting coronary artery disease (CAD) risk. However, revealing the causal genes responsible for the observed associations is challenging. In the present study, we aimed to prioritize CAD-relevant genes …

ru, gb, hr, us, nl (code pays fourni par la source)

The role of the fault-block structure of the continental margin in the generation of the strongest subduction earthquakes

I. S. Vladimirova, Yu. V. Gabsatarov, Dmitry Alexeev, L. I. Lobkovsky

Modern seismotectonic studies are aimed at obtaining a self-consistent explanation of fault zone heterogeneity, the rupture process, recurrence times and rupture mode of large earthquake sequences. In subduction regions large earthquakes are often characterized by very long source zones and complex long-term …

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