Katsuichi Ohtsuki

Development and Evaluation of a Novel 99mTc-Labeled Annexin A5 for Early Detection of Response to Chemotherapy

Kazuma Ogawa, Katsuichi Ohtsuki, T Shibata, Miho Aoki et autres

(99m)Tc-HYNIC-annexin A5 can be considered as a benchmark in the field of apoptosis imaging. However, (99m)Tc-HYNIC-annexin A5 has characteristics of high uptake and long retention in non-target tissues such as kidney and liver. To minimize this problem, we developed a novel (99m)Tc-labeled …

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Abstract 15492: Imaging Oxidative Stress in Unstable Atherosclerotic Plaque With Iodine-125-Labeled 4-Hydroxy-2-Nonenal in vivo

Tomoki Doue, Eri Iwai‐Kanai, Katsuichi Ohtsuki, Satoaki Matoba et autres

Introduction: Oxidative stress contributes to the progress of atherosclerosis as inflammation, serum lipid overload, and aging do. The early identification of unstable atherosclerotic plaque, which...

Cardioprotective Effects of Erythropoietin in Rats Subjected to Ischemia–Reperfusion Injury: Assessment of Infarct Size with99mTc-Annexin V

Tomoki Doue, Katsuichi Ohtsuki, Kazuma Ogawa, Masashi Ueda et autres

UNLABELLED: Administration of erythropoietin (EPO) during or immediately after myocardial ischemia can reduce subsequent myocardial apoptosis, a key phenomenon in myocardial ischemia-reperfusion injury. In this study, we assessed the effect of EPO on (99m)Tc-annexin V myocardial uptake and whether the accumulation of …

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FRS-015 The Feasibility of ^ Tc-Annexin V to Evaluate the Anti-atherosclerotic Therapy by HMG-CoA Reductase Inhibitor Pravastatin in Cholesterol-fed Rabbits(Topics in Nuclear Cardiology(I),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Tomoki Doue, Katsuichi Ohtsuki, Takatoh Hikosaka, Kazuma Ogawa et autres

Beneficial Effect of Gabexate Mesilate on Microscopic Polyangiitis With Renal Dysfunction and Pulmonary Hemorrhage

Kiichiro Miyawaki, Jun Shiraishi, Yasuhiko Tsutsumi, Emi Shiraishi et autres

Corticosteroids and cyclophosphamide are the mainstay of the treatment of microscopic polyangiitis involving pulmonary hemorrhage or rapidly progressive glomerulonephritis. However, patients with advanced age are unable to tolerate this combined therapy, because of a relatively high incidence of side effects including infection, …

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The Feasibility of ^ Tc-Annexin V to Quantitatively Evaluate Cardioprotective Effect of Erythropoietin in an Acute Ischemia-reperfusion Rat Model(Advances in Nuclear Cardiology (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Tomoki Doue, Katsuichi Ohtsuki, Masashi Ueda, Kazuma Ogawa et autres

Beneficial Effect of Cibenzoline on Left Ventricular Pressure Gradient With Sigmoid Septum

Chika Konishi, Jun Shiraishi, Naoko Muraguchi, Katsuichi Ohtsuki et autres

An 83-year-old woman with hypertension was admitted to hospital with episodes of dyspnea on effort after having breakfast. Physical examination revealed a systolic murmur at the left sternal border in the third to fourth intercostal space. Cross-sectional echocardiography showed a sigmoid-shaped interventricular …

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Investigation of Plasma Soluble Form of Fas and Fas-Ligand in Patients with Hypertrophic Cardiomyopathy

Kan Zen, Takahisa Sawada, Norifumi Urao, Takato Hikosaka et autres

ACE Inhibitor Improves Impaired Myocardial Energy Metabolism and Diastolic Function as Well as Left Ventricular Hypertrophy inHypertensive Patients

Katsuichi Ohtsuki, Hiroki Sugihara, Takahisa Sawada, Akihiro Azuma et autres

Detection of Monocyte Chemoattractant Protein-1 Receptor Expression in Experimental Atherosclerotic Lesions

Katsuichi Ohtsuki, Motoya Hayase, Koichi Akashi, Susan Kopiwoda et autres

BACKGROUND: Monocytes, a common component of atheroma, are attracted to the lesion site in response to chemotactic signals, particularly expression of monocyte chemoattractant peptide 1 (MCP-1). This study assessed the feasibility of using radiolabeled MCP-1 to identify monocytes and macrophages that have …

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Apoptosis: The importance of nuclear medicine

Francis G. Blankenberg, Jonathan Tait, Katsuichi Ohtsuki, H. William Strausś

Apoptosis is a genetically controlled, energy-dependent process which removes unwanted cells from the body. Because of its orderly progression, apoptosis is also known as programmed cell death or cell suicide. Once initiated, apoptosis is characterized by a series of biochemical and morphological …

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Long-Term Follow-Up of Myocardial Perfusion and Metabolic Images in a Patient With Hypertrophic Cardiomyopathy

Katsuichi Ohtsuki, Chio Okuyama, Yo Ushijima

A 54-year-old woman was hospitalized in 1989 because of palpitations. She had a family history of hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy was diagnosed by two-dimensional echocardiography, cardiac catheterization, and myocardial biopsy. A coronary arteriogram disclosed normal coronary arteries. She had received diltiazem and …

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