Audrey Brenot

Development of in vitro models to study CD137 agonist antibody mediated hepatotoxicity 2331460

April Masters, Miguel Miranda-Roman, Audrey Brenot, Birgit Fogal

Abstract Introduction Immune-mediated hepatotoxicity from biotherapeutics is a growing concern in drug development due to the poor translatability of preclinical safety findings and the lack of suitable in vitro models to predict in vivo risks. Urelumab, a CD137 agonist antibody, presented with …

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Abstract 4801: DDR2 positive endothelial cells promote angiogenesis and metastasis in breast tumors

Alessandra DiMauro, Audrey Brenot, Julien Lesage, J. Weber et autres

Abstract The collagen receptor DDR2, a receptor tyrosine kinase, contributes to breast cancer progression through actions in both invasive tumor cells and tumor stromal cells. In the tumor stroma, DDR2 is predominantly expressed by cancer associated fibroblasts (CAFs) and therein contributes to …

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Tailoring the Methods of Conjugation and Characterization for a Replication-Competent, Live, Viral Vector

Elise Ishida, Richard Dambra, Sally Ye, Steven Anderlot et autres

Optimized functionalization of virus particles can expand the toolbox available for the development of viral vector-based therapies. However, labeling of a large, complex, and biologically active particle introduces distinct technological challenges for subsequent purification and characterization steps. Moreover, the process of labeling …

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Data from Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues

Priscilla Y. Hwang, Audrey Brenot, Ashley C. King, Gregory D. Longmore et autres

Abstract Collective cell migration is an adaptive, coordinated interactive process involving cell–cell and cell–extracellular matrix (ECM) microenvironmental interactions. A critical aspect of collective migration is the sensing and establishment of directional movement. It has been proposed that a subgroup of cells known …

Movie 1 from Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues

Priscilla Y. Hwang, Audrey Brenot, Ashley C. King, Gregory D. Longmore et autres

Movie demonstrating collective migration

Supplementary Data from Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues

Priscilla Y. Hwang, Audrey Brenot, Ashley C. King, Gregory D. Longmore et autres

These are supplemental figures 1-5, which contain extra data supporting figures 1-7

Movie 3 from Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues

Priscilla Y. Hwang, Audrey Brenot, Ashley C. King, Gregory D. Longmore et autres

Movie demonstrating DDR2-/- cells migration

Movie 2 from Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues

Priscilla Y. Hwang, Audrey Brenot, Ashley C. King, Gregory D. Longmore et autres

Movie demonstrating K14-GFP migration

Supplementary Data from Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues

Priscilla Y. Hwang, Audrey Brenot, Ashley C. King, Gregory D. Longmore et autres

These are supplemental figures 1-5, which contain extra data supporting figures 1-7

Movie 1 from Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues

Priscilla Y. Hwang, Audrey Brenot, Ashley C. King, Gregory D. Longmore et autres

Movie demonstrating collective migration

Movie 3 from Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues

Priscilla Y. Hwang, Audrey Brenot, Ashley C. King, Gregory D. Longmore et autres

Movie demonstrating DDR2-/- cells migration

Supplementary Data from Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues

Priscilla Y. Hwang, Audrey Brenot, Ashley C. King, Gregory D. Longmore et autres

These are the movie legends and supplemental methods