Haoxuan Yang

Ciliary IFT ‐B Transportation Plays an Important Role in Human Endometrial Receptivity Establishment and is Disrupted in Recurrent Implantation Failure Patients

Haoxuan Yang, Jing Zhang, Fei Yan, Yihong Chen et autres

The lack of accurate understanding of cellular physiology and pathophysiology during the WOI constitutes the major obstacle to correct diagnosis and treatment for patients with recurrent implantation failure (RIF). The role of cilia as one of the key organelles in endometrial epithelium …

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Metabolic profiling identifies Qrich2 as a novel glutamine sensor that regulates microtubule glutamylation and mitochondrial function in mouse sperm

Guohui Zhang, Juncen Guo, Haoxuan Yang, Qing Li et autres

In our prior investigation, we discerned loss-of-function variants within the gene encoding glutamine-rich protein 2 (QRICH2) in two consanguineous families, leading to various morphological abnormalities in sperm flagella and male infertility. The Qrich2 knockout (KO) in mice also exhibits multiple morphological abnormalities …

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flu vaccine data

Haoxuan Yang

flu vaccine

Correction: Single Cell Proteomics Profiling Reveals That Embryo-Secreted TNF-α Plays a Critical Role During Embryo Implantation to the Endometrium

Jiao Lv, Xudong Shan, Haoxuan Yang, Yuting Wen et autres

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Single Cell Proteomics Profiling Reveals That Embryo-Secreted TNF-α Plays a Critical Role During Embryo Implantation to the Endometrium

Jiao Lv, Xudong Shan, Haoxuan Yang, Yuting Wen et autres

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The Key Role of Peroxisomes in Follicular Growth, Oocyte Maturation, Ovulation, and Steroid Biosynthesis

Shan Wang, Haoxuan Yang, Yonglun Fu, Xiaoming Teng et autres

The absence of peroxisomes can cause disease in the human reproductive system, including the ovaries. The available peroxisomal gene-knockout female mouse models, which exhibit pathological changes in the ovary and reduced fertility, are listed in this review. Our review article provides the …

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Single Cell Proteomics Profiling Revealing that Embryo Secreted TNF-α play Critical Role during Embryo Implantation to Endometrium

Jiao Lv, Xudong Shan, Haoxuan Yang, Zhang Xue-guang et autres

Abstract Problem: Although it has long been known that endometrium secreted cytokines play critical role during embryo implantation, whether cytokines secreted from embryo is relevant to embryo quality and is actively involved in embryo attachment remain unclear.Method of study: The concentration of …

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Dietary selenium deficiency and supplementation differentially modulate the expression of two ER-resident selenoproteins (selenoprotein K and selenoprotein M) in the ovaries of aged mice: Preliminary data

Izhar Hyder Qazi, Haoxuan Yang, Christiana Angel, Bo Pan et autres

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Impact of Dietary Selenium on Modulation of Expression of Several Non-Selenoprotein Genes Related to Key Ovarian Functions, Female Fertility, and Proteostasis: a Transcriptome-Based Analysis of the Aging Mice Ovaries

Izhar Hyder Qazi, Yutao Cao, Haoxuan Yang, Christiana Angel et autres

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Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice

Haoxuan Yang, Izhar Hyder Qazi, Bo Pan, Christiana Angel et autres

Female reproductive (ovarian) aging is distinctively characterized by a markedly reduced reproductive function due to a remarkable decline in quality and quantity of follicles and oocytes. Selenium (Se) has been implicated in playing many important biological roles in male fertility and reproduction; …

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Melatonin Improves In Vitro Development of Vitrified-Warmed Mouse Germinal Vesicle Oocytes Potentially via Modulation of Spindle Assembly Checkpoint-Related Genes

Zhenzheng Wu, Bo Pan, Izhar Hyder Qazi, Haoxuan Yang et autres

The present study aimed to investigate the effect of melatonin (MT) supplementation on in vitro maturation of vitrified mouse germinal vesicle (GV) oocytes. The fresh oocytes were randomly divided into three groups: untreated (control), or vitrified by open-pulled straw method without (vitrification …

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Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences

Izhar Hyder Qazi, Christiana Angel, Haoxuan Yang, Evangelos Zoidis et autres

Selenium (Se) is an important trace mineral having many essential roles at the cellular and organismal levels in animal and human health. The biological effects of Se are mainly carried out by selenoproteins (encoded by 25 genes in humans and 24 in …

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