Xanthippi Chatzistavrou

A New Bioactive Glass‐Based Hybrid Bioink With Enhanced Cell Viability and Antibacterial Properties

Adam C. Marsh, Ehsanul Hoque Apu, Theofania Kleisoura, Romila Manchanda et autres

ABSTRACT Recent advances in three‐dimensional bioprinting (3DBP) technology enable the production of customized bone substitutes. However, osteoconductive materials in their particulate phase may damage cells during extrusion resulting in poor cell viability after 3DBP. We developed a cell‐friendly, osteopromotive, and antibacterial‐based bioink. …

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ADA-GEL composite hydrogel films incorporating mesoporous bioactive glass nanoparticles and silver-doped bioactive glass nanoparticles for biomedical applications

Asimenia Lekidou, Thomas Papatasos, Qaisar Nawaz, Xanthippi Chatzistavrou et autres

Hydrogels made from natural polymers are widely used in biomedical engineering as they resemble the extracellular matrix. Alginate dialdehyde-gelatin (ADA-GEL) hydrogels are notable for their biocompatibility, biodegradability, and adjustable crosslinking. However, their limited mechanical strength and bioactivity present significant challenges for use …

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A 3D SVZonChip Model for In Vitro Mimicry of the Subventricular Zone Neural Stem Cell Niche

Ioannis Angelopoulos, Konstantinos Ioannidis, Konstantina Lyroni, Dimitris Vlassopoulos et autres

Neural stem cells (NSCs) are crucial components of the nervous system, primarily located in the subventricular zone (SVZ) and subgranular zone (SGZ). The SVZ neural stem cell niche (NSCN) is a specialized microenvironment where growth factors and extracellular matrix (ECM) components collaborate …

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Advancements in reliability of mechanical performance of 3D PRINTED Ag-doped bioceramic antibacterial scaffolds for bone tissue engineering

Adam C. Marsh, Yaozhong Zhang, Yadav Wagley, Parker K. Acevedo et autres

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Tailored Coatings for Enhanced Performance of Zinc–Magnesium Alloys in Absorbable Implants

David Hernández Escobar, Natalia Pajares‐Chamorro, Xanthippi Chatzistavrou, Kurt David Hankenson et autres

Absorbable metals exhibit potential for next-generation temporary medical implants, dissolving safely in the body during tissue healing and regeneration. Their commercial incorporation could substantially diminish the need for additional surgeries and complications that are tied to permanent devices. Despite extensive research on …

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Silver-releasing bioactive glass nanoparticles for infected tissue regeneration

Natalia Pajares‐Chamorro, Sandra Hernández-Escobar, Yadav Wagley, Parker K. Acevedo et autres

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High Boron Content Enhances Bioactive Glass Biodegradation

Amina Gharbi, Hassane Oudadesse, Hafedh el Feki, Wissem Cheikhrouhou-Koubaa et autres

Derived Hench bioactive glass (BaG) containing boron (B) is explored in this work as it plays an important role in bone development and regeneration. B was also found to enhance BaG dissociation. However, it is only possible to incorporate a limited amount …

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Unraveling the mechanisms of inhibition of silver‐doped bioactive glass–ceramic particles

Natalia Pajares‐Chamorro, Josh Lensmire, Neal D. Hammer, Jonathan W. Hardy et autres

Infections are a major concern in orthopedics. Antibacterial agents such as silver ions are of great interest as broad-spectrum biocides and have been incorporated into bioactive glass-ceramic particles to control the release of ions within a therapeutic concentration and provide tissue regenerative …

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Materials for restoring lost Activity: Old drugs for new bugs

Natalia Pajares‐Chamorro, Neal D. Hammer, Xanthippi Chatzistavrou

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A New Bioink for Improved 3D Bioprinting of Bone-Like Constructs

Adam C. Marsh, Ehsanul Hoque Apu, Marcus Bunn, Christopher H. Contag et autres

ABSTRACT Bone tissue loss can occur due to disease, trauma or following surgery, in each case treatment involving the use of bone grafts or biomaterials is usually required. Recent development of three-dimensional (3D) bioprinting (3DBP) has enabled the printing of customized bone …

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Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease

Yonatan R. Lewis‐Israeli, Aaron H. Wasserman, Mitchell A. Gabalski, Brett D. Volmert et autres

Congenital heart defects constitute the most common human birth defect, however understanding of how these disorders originate is limited by our ability to model the human heart accurately in vitro. Here we report a method to generate developmentally relevant human heart organoids …

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Highlights on Advancing Frontiers in Tissue Engineering

Nureddin A. Ashammakhi, Amin GhavamiNejad, Rumeysa Tutar, Annabelle T. R. Fricker et autres

The field of tissue engineering continues to advance, sometimes in exponential leaps forward, but also sometimes at a rate that does not fulfill the promise that the field imagined a few decades ago. This review is in part a catalog of success …

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