Miwako Nomura

Survival outcomes in EGFR-mutant versus wild-type locally advanced non-small cell lung cancer treated with definitive chemoradiotherapy alone in the pre-PACIFIC/LAURA trial era: A systematic review and meta-analysis using reconstructed individual patient data

Satoru Ochiai, Takamitsu Mase, Yutaka Toyomasu, Akinori Takada et autres

BACKGROUND AND AIMS: This study evaluated the prognostic impact of epidermal growth factor receptor (EGFR) mutations in locally advanced non-small cell lung cancer (NSCLC) treated with definitive chemoradiotherapy (CRT) alone in cohorts in which consolidation durvalumab or osimertinib was not administered as …

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Superficial Temporal Artery‐Based ReMAP : A Case Report Series in Head and Neck Cancer Intra‐Arterial Chemotherapy

Wataru Makino, Nobukazu Fuwa, Akira Matsumoto, Shinichi Ogawa et autres

BACKGROUND: Intra-arterial chemotherapy (IAC) can be highly effective for advanced head and neck cancers but often necessitates complex procedures and prolonged hospitalization. Herein, we demonstrate the utility of the repeatable microcatheter access port (ReMAP) system for streamlining IAC. METHODS: Two patients with …

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Survival Outcomes in Egfr Mutant Versus Wild-Type Locally Advanced Non-Small Cell Lung Cancer Treated with Chemoradiotherapy: A Systematic Review and Meta-Analysis Based on Reconstructed Individual Patient Data

Takamitsu Mase, Yutaka Toyomasu, Akinori Takada, Miwako Nomura et autres

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Combining Vascular Targeting Agents with Radiation: An Effective Anti-Tumor Treatment but Associated with Radiation-Induced Systemic Toxicity

Miwako Nomura, Rumi Murata, Line Brøndum, E. Ehrnrooth et autres

This study investigated the effect of combining radiation with an angiogenesis inhibitor and vascular disrupting agent on tumor response and systemic toxicity. CDF1 mice with 200 mm3 foot implanted C3H mammary carcinomas were treated with TNP-470 (100 mg/kg every second day for …

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Chemoradiotherapy with intra-arterial chemotherapy using ECAS for locally advanced tongue cancer requiring total glossectomy

Nobukazu Fuwa, Miwako Nomura, S. Ito, Tomohito Fuke et autres

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Drug concentration estimation using contrast-enhanced MRI in intra-arterial chemotherapy for head and neck cancers

S. Ito, Nobukazu Fuwa, Miwako Nomura, Suguru Ota et autres

MRI (magnetic resonance imaging)造影剤をカテーテルより投与し，その灌流域を確認する方法(MRFC : magnetic resonance flow check)が開発された．本研究では MRI 造影剤を複数の動脈に投与し灌流域の確認だけでなく， 灌流域での造影剤濃度と相関するとされる組織の 1/T１ の変化量(⊿１/T１)を計測することにより，組織内の抗がん剤 濃度を推計が可能になるかどうかについて検証した． 方法 : T１ 値測定の最適な方法は IR 法(Inversion Recovery method)であるが，実用性に難点があるため，FSE 法 (Fast spin echo method)を用い最適な撮像条件をファントム検討で求めた．次にファントム検討と同一の撮像条件を 使用し，舌癌７例を対象に MRI 検査を施行した(表１ : Table 1) ．舌動脈から造影剤を流した場合(図１ａ : Fig. 1b)

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Initial Experience of Intra-Arterial Chemotherapy Using a Novel External Carotid Arterial Sheath System Combined with Radiotherapy and Systemic Chemotherapy for Locally Advanced Tongue Cancer

Miwako Nomura, Nobukazu Fuwa, Shintaro Ito, Yutaka Toyomasu et autres

We retrospectively evaluated the safety and effectiveness of an external carotid arterial sheath (ECAS) for intra-arterial chemotherapy (IACT) for locally advanced tongue cancer. Thirty-one patients with the Union for International Cancer Control’s 8th TNM stage III–IV tongue cancer underwent IACT using the …

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Intratumor hemodynamics using contrast-enhanced MRI in intra-arterial chemotherapy for head and neck cancer

Shintaro Ito, Nobukazu Fuwa, Miwako Nomura, Takashi Daimon et autres

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Verification of the junctional dose for irradiation of the chest wall and supraclavicular regions under the circumstances of advanced technologies

Kengo Iwaki, Akira Kamaya, Nobukazu Fuwa, Kazuaki Tanisada et autres

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Drug concentration estimation using contrast-enhanced MRI in intra-arterial chemotherapy for head and neck cancers

Shintaro Ito, Nobukazu Fuwa, Miwako Nomura, Suguru Ota et autres

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Intra-arterial chemoradiotherapy including internal carotid arterial infusion for advanced maxillary sinus cancer with orbital invasion

Nobukazu Fuwa, Miwako Nomura, Masanori Taniguchi, Tomohisa Fuke et autres

眼窩内に上顎洞癌が浸潤した3症例に視力温存を目的とした内頸動脈からの動注治療を加えた化学放射線治療を施行した。2例には全身化学療法として2回のTPF（taxotere，cisplatin，5FU）を施行した。動注療法は浅側頭動脈に挿入したECAS （External Carotid Arterial Sheath）からマイクロカテーテルを目的動脈に挿入。動注薬剤はチオ硫酸ナトリウム併用下に週1回CDDP（35mg/m2〜50mg/m2）を投与。放射線治療はIMRT（intensity modulated radiation therapy）を用いた。まだ経過期間は短いが3例とも眼窩内腫瘍は制御されており視力低下も認めていない。上顎洞癌眼窩内進展例に対し，内頸動脈からの動注治療を加えた化学放射線治療は治療選択肢の一つになり得る。

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A comparison of two types of microcatheters used for a novel external carotid arterial sheath system for intra-arterial chemotherapy of head and neck cancer

Miwako Nomura, Nobukazu Fuwa, Yutaka Toyomasu, Akinori Takada et autres

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