Johann S. Bergholz

Suppressing phosphatidylserine externalization overcomes cancer immune evasion and enhances immunotherapy

Johann S. Bergholz, Grace Trombley, Gwendolyn Cusing, Zhaoqi Li et autres

Immune checkpoint blockade (ICB) has transformed cancer therapy, yet many tumors remain refractory to treatment due to diverse immune evasion mechanisms. To uncover novel drivers of ICB resistance, we performed an in vivo CRISPR-Cas9 screen in mice with increasing levels of immune …

us (code pays fourni par la source)

Supplementary Table 1 from PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis

Shuang Tang, Qian Zhou, Johann S. Bergholz, Tao Jiang et autres

Key Resources Table

Supplementary Figure S1-6 from PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis

Shuang Tang, Qian Zhou, Johann S. Bergholz, Tao Jiang et autres

Figure S1. Bio-ID screening reveals PI3Kβ, but not PI3Kα, as a selective interactor of EPHA2 in PTEN-null cancer cells. Figure S2. PTEN acts as a protein tyrosine phosphatase regulating PI3Kβ- EPHA2 interaction through dephosphorylation of tyrosine-962 (Y962) on PI3Kβ and impact tumorigenesis. …

Data from PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis

Shuang Tang, Qian Zhou, Johann S. Bergholz, Tao Jiang et autres

Abstract Loss of the tumor-suppressor PTEN drives cancer progression and therapeutic resistance, yet no targeted therapies exist for PTEN-deficient tumors. In this study, we identify a critical druggable mechanism in which PTEN loss induces PI3Kβ phosphorylation for tumorigenesis. Using the BioID interactome, …

PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis

Shuang Tang, Johann S. Bergholz, Weihua Wang, Renlei Ji et autres

Loss of the tumor-suppressor PTEN drives cancer progression and therapeutic resistance, yet no targeted therapies exist for PTEN-deficient tumors. In this study, we identify a critical druggable mechanism in which PTEN loss induces PI3Kβ phosphorylation for tumorigenesis. Using the BioID interactome, we …

cn, us, il (code pays fourni par la source)

Genomic landscape and immunological profile of glioblastoma in East Asian patients

Sheng Zhong, Bo Wu, Frank Dubois, Davy Deng et autres

Glioblastoma multiforme (GBM) shows profound inter- and intratumoral heterogeneity, but differences across ancestries remain understudied. We assemble the largest cohort of GBMs from East Asian patients (EAS-GBM) and perform genomic and transcriptomic analyses. Transcriptomic clustering reveals distinct EAS-GBM molecular subtypes-proliferative (PL), neurosynaptic …

cn, us, de (code pays fourni par la source)

Abstract PS4-07: Residual disease after HER2 inhibition is driven by a primary tumor subpopulation expressing an ERBB2-low associated transcriptional program

Sheheryar Kabraji, Weihua Wang, Yali Zhang, Johann S. Bergholz et autres

Abstract Background: In HER2+ breast cancer (BC), residual disease (RD) after neoadjuvant HER2 inhibition is associated with increased risk of recurrence. However, the genetic and non-genetic resistance mechanisms underlying RD remain incompletely characterized. Here we used single nuclei (sn) RNA and DNA …

Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response

Xiadi He, Qiwei Wang, Xin Cheng, Weihua Wang et autres

cn, us (code pays fourni par la source)

Supplementary Figure S4 from Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor–positive Breast Cancer

Cristina Guarducci, Agostina Nardone, Douglas Russo, Zsuzsanna Nagy et autres

Focal CNVs in PDX1526-Mut and PDX1415-WT and enriched transcription pathways between the two PDX models.

Supplementary Figure S3 from Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor–positive Breast Cancer

Cristina Guarducci, Agostina Nardone, Douglas Russo, Zsuzsanna Nagy et autres

MYC transcription is impaired by CDK7 inhibition.

Supplementary Figure S1 from Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor–positive Breast Cancer

Cristina Guarducci, Agostina Nardone, Douglas Russo, Zsuzsanna Nagy et autres

On-target effect of SY-1365 and modulation of WT/DOX-Y537S mutant MCF7 cells gene expression after SY-1365 treatment over time.

Supplementary Figure S7 from Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor–positive Breast Cancer

Cristina Guarducci, Agostina Nardone, Douglas Russo, Zsuzsanna Nagy et autres

Effect of samuraciclib on PalboS and PalboR T47D cells.