Sophie Tartare‐Deckert

Spectral CytoFRET2 identifies lysine acetyltransferase inhibitors as modulators of vimentin assembly

Frédéric Larbret, Marie Irondelle, Sophie Tartare‐Deckert, Marcel Deckert

ABSTRACT Cytoskeletal plasticity is a defining feature of cancer progression, enabling tumor cells to adapt their morphology, mechanics, and migratory behavior during invasion and metastasis. Although actin filaments, microtubules, and intermediate filaments are known to cooperate in these processes, the molecular mechanisms …

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Extracellular matrix stiffness determines the phenotypic behavior of dedifferentiated melanoma cells through a DDR1/2-dependent YAP mechanotransduction pathway

Margaux Lecacheur, Ilona Berestjuk, Alexandrine Carminati, Océane Bouvet et autres

Extracellular matrix (ECM) stiffening is a biophysical hallmark of solid tumors. Cutaneous melanoma is an aggressive malignancy characterized by high heterogeneity and phenotypic plasticity in which melanoma cells switch from a proliferative and differentiated phenotype to an invasive, dedifferentiated and therapy-resistant state. …

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Extracellular matrix stiffness determines the phenotypic behavior of dedifferentiated melanoma cells through a DDR1/2-dependent YAP mechanotransduction pathway

Margaux Lecacheur, Ilona Berestjuk, Alexandrine Carminati, Mira Rabbaa et autres

Abstract Extracellular matrix (ECM) stiffening is a biophysical hallmark of solid tumors. Cutaneous melanoma is an aggressive malignancy characterized by high heterogeneity and phenotypic plasticity in which melanoma cells switch from a proliferative and differentiated phenotype to an invasive, dedifferentiated and therapy-resistant …

USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization

Pierric Biber, Alexandrine Carminati, Walaa Mohager, Mickaël Ohanna et autres

Ubiquitin removal by deubiquitinases (DUBs) is crucial for protein activity and homeostasis. While tumor cells adapt to treatment and environmental stress, the role of DUBs in sensing mechanical signals from the extracellular matrix (ECM) remains an unexplored area. Using melanoma cells cultured …

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Extracellular matrix stiffness determines the phenotypic behavior of dedifferentiated melanoma cells through a DDR1/2-dependent YAP mechanotransduction pathway

Sophie Tartare‐Deckert, Margaux Lecacheur, Ilona Berestjuk, Alexandrine Carminati et autres

fr (code pays fourni par la source)

USP9X is a Mechanosensitive Deubiquitinase that Controls Tumor Cell Invasiveness and Drug Response Through YAP Stabilization

Pierric Biber, Alexandrine Carminati, Walaa Mohager, Mickaël Ohanna et autres

fr (code pays fourni par la source)

USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization

Pierric Biber, Alexandrine Carminati, Christophe A. Girard, Walaa Mohager et autres

Post-translational modification by ubiquitin is crucial for protein turnover. Deubiquitinases (DUBs) remove ubiquitin chains from target proteins to prevent their degradation by the proteasome, thus acting as gatekeepers of protein homeostasis alongside the ubiquitin-proteasome system (UPS). Tumor cells exhibit remarkable plasticity, enabling …

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Data from Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner

Michaël Cerezo, Mélanie Tichet, Patricia Abbe, Mickaël Ohanna et autres

Abstract Metformin was reported to inhibit the proliferation of many cancer cells, including melanoma cells. In this report, we investigated the effect of metformin on melanoma invasion and metastasis development. Using different in vitro approaches, we found that metformin inhibits cell invasion …

Supplementary Figure S2 from Targeting the Sphingosine 1-Phosphate Axis Exerts Potent Antitumor Activity in BRAFi-Resistant Melanomas

David Garandeau, Justine Noujarède, J. C. Leclerc, Caroline Imbert et autres

Supplementary Figure S2 shows the plasma SL levels in patients responding or not to BRAFi

Supplementary Figure S3 from Targeting the Sphingosine 1-Phosphate Axis Exerts Potent Antitumor Activity in BRAFi-Resistant Melanomas

David Garandeau, Justine Noujarède, J. C. Leclerc, Caroline Imbert et autres

Supplementary Figure S3 shows the effect of SKI-I on cell death in BRAFi-sensitive and -resistant melanoma cells

Supplementary Figure S1 from Targeting the Sphingosine 1-Phosphate Axis Exerts Potent Antitumor Activity in BRAFi-Resistant Melanomas

David Garandeau, Justine Noujarède, J. C. Leclerc, Caroline Imbert et autres

Supplementary Figure S1 shows the effects of PLX on S1PR expression and cell death in BRAFi-sensitive and -resistant melanoma cells

Supplementary Figure S4 from Targeting the Sphingosine 1-Phosphate Axis Exerts Potent Antitumor Activity in BRAFi-Resistant Melanomas

David Garandeau, Justine Noujarède, J. C. Leclerc, Caroline Imbert et autres

Supplementary Figure S4 shows that MITF expression is associated to S1PR1 in PLX-treated melanoma cells