Karim Benihoud

A plasma proteomic signature of cancer-related sarcopenia implicates the IGFBP axis in muscle dysfunction

Filippo Gustavo Dall’Olio, Wael Zrafi, Xinran SONG, Littisha Lawrance et autres

Cancer-related sarcopenia is associated with poor clinical outcomes but remains difficult to define and quantify in routine oncology practice. Current assessments rely on imaging and functional scales that are time-consuming and provide limited biological insight. We aimed to identify a plasma proteomic …

fr, gb, ca, ru (code pays fourni par la source)

Adenovirus phagocytosis by neutrophils triggers a pro-inflammatory response

Salomé Laurans, Soizic Huerre, Olivier Dellis, Céline Férard et autres

Abstract Adenoviruses are common pathogens that have been engineered and used for medical purposes. Their recognition by innate immune cells such as macrophages and dendritic cells has been widely studied, but very little information is available on adenovirus interaction with neutrophils. Using …

fr (code pays fourni par la source)

A plasma proteomic signature of cancer-related sarcopenia implicates the IGFBP axis in muscle dysfunction

Filippo Gustavo Dall’Olio, Wael Zrafi, Xinran SONG, Littisha Lawrance et autres

fr, gb, ca (code pays fourni par la source)

Enhanced Expression of IL32 mRNA in Skeletal Muscles in the Context of Head and Neck Carcinomas

Imane Baïche, Héla Hachicha, Thierry Ragot, Céline Gracia et autres

BACKGROUND: Cancer-related sarcopenia (CRS) is a significant complication of head and neck carcinoma (HNC), characterised by muscle degeneration and poor clinical outcomes. Although various dietary and therapeutic interventions have been explored, most of them remain empirical, and the molecular mechanisms underlying CRS …

fr, ru (code pays fourni par la source)

WITHDRAWN: 166P Plasma proteomic signature of sarcopenia in advanced cancer patients and its biological correlates

Filippo Gustavo Dall’Olio, Wael Zrafi, Xue Song, Littisha Lawrance et autres

fr (code pays fourni par la source)

ctDNA tumor fraction (TF) to predict response to nivolumab in recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): An analysis of the multicentric phase 2 TOPNIVO trial.

Filippo Gustavo Dall’Olio, Wael Zrafi, M. Moreau, Rebecca Ibrahim et autres

6047 Background: Anti-PD1 provides clinical benefits in HNSCC, yet biomarkers of response remain poorly defined. In other cancer types, measures of ctDNA shedding, such as TF, have been shown to correlate with treatment outcomes. Little is known about ctDNA shedding in HNSCC …

fr (code pays fourni par la source)

922P Genomic instability as a biomarker for advanced cancer of the head and neck

Filippo Gustavo Dall’Olio, W.S. Zrafi, D. Al Burshaid, J. Bassil et autres

fr (code pays fourni par la source)

Expression augmentée des ARN messagers IL-32 et BIRC3 dans les muscles sarcopéniques des patients porteurs de carcinomes des voies aérodigestives supérieures

Fei Chen, Thierry Ragot, Karim Benihoud, Yegor Vassetzky et autres

International audience

Abstract 2414: Feasibility and clinical utility of blood based NGS in head and neck carcinomas: A single center experience from precision medicine program

Filippo Gustavo Dall’Olio, Damien Vasseur, Léa Loriguet, François Régis Ferrand et autres

Abstract Background: While blood-based next-generation sequencing is increasingly integral to clinical practice across various malignancies, the routine assessment of circulating tumor DNA (ctDNA) in head and neck cancer remains underexplored, with limited supportive data. Methods: This study focused on head and neck …

fr (code pays fourni par la source)

Antigen self-anchoring onto bacteriophage T5 capsid-like particles for vaccine design

Émeline Vernhes, Linda Larbi Chérif, Nicolas Ducrot, Clément Vanbergue et autres

Abstract The promises of vaccines based on virus-like particles stimulate demand for universal non-infectious virus-like platforms that can be efficiently grafted with large antigens. Here, we harnessed the modularity and extreme affinity of the decoration protein pb10 for the capsid of bacteriophage …

fr (code pays fourni par la source)

NGR-bearing human adenovirus type 5 infects cells in flotillin- or caveolin-mediated manner depending on the NGR insertion site

Ksenija Božinović, Davor Nestić, Elodie Grellier, Najat Raddi et autres

hr, fr (code pays fourni par la source)

Data from Intratumoral Induction of CD103 Triggers Tumor-Specific CTL Function and CCR5-Dependent T-Cell Retention

Katarzyna Franciszkiewicz, Audrey Le Floc’h, Abdelali Jalil, Frédéric Vigant et autres

Abstract We have reported previously that the interaction of αE(CD103)β7 integrin, expressed on a CD8+ tumor-infiltrating lymphocyte (TIL) clone but not on a peripheral blood lymphocyte (PBL) counterpart, with the epithelial marker E-cadherin on human lung tumor cells plays a crucial role …