Hande Turna

Comparative Prognostic Value of Systemic Inflammation-Based Biomarkers in Advanced Non-Small Cell Lung Cancer Treated with First-Line Immunotherapy

Şahin Bedir, G. Sen, Hamza Abbasov, Murad Guliyev et autres

Background: We assessed the prognostic value of the pan-immune–inflammation value (PIV), systemic immune–inflammation index (SII), lung immune prognostic index (LIPI), and c-reactive protein–albumin–lymphocyte (CALLY) index in advanced non-small cell lung cancer (NSCLC) treated with first-line immune checkpoint inhibitor (ICI)-based therapy. Methods: This …

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A Subset of Cutaneous Melanoma Express Oncofetal Cripto-1 Protein: Correlation of Histopathology and Prognosis

Mine Önenerk, Ayşe Hanım Namal, Ahu Senem Demiröz, Zehra Şahin et autres

Objective: Melanoma has a poor prognosis in advanced stages. The study aimed to investigate the immunohistochemical expression of Cripto-1 (CR-1) and its relationship with clinicopathological parameters in cutaneous melanoma cases. Methods: Cutaneous melanoma cases diagnosed at Cerrahpaşa Medical Faculty between January 2016 …

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Association between obesity and outcomes of first-line CDK4/6 inhibitor therapy in metastatic breast cancer: a multicenter real-world study

Murat Günaltılı, Murad Guliyev, Zeliha Birsin, Emir Çerme et autres

Obesity has been associated with inferior outcomes in early-stage breast cancer, but its clinical relevance in metastatic disease treated with CDK4/6 inhibitors remains uncertain. We retrospectively analyzed 332 patients with hormone receptor-positive/HER2-negative metastatic breast cancer who received first-line ribociclib or palbociclib plus …

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Neuroimmune Crosstalk: Peripheral Nervous System Disorders After Immune Checkpoint Inhibitors

Ayşegül Gündüz, Merve İriş, Zeliha Birsin, Hande Turna et autres

OBJECTIVE: This study aimed to identify the frequency and types of peripheral nervous system involvement, associated clinical features, treatment options, and prognosis in patients receiving immune checkpoint inhibitors (ICIs) for the treatment of malignancy. METHOD: This is a retrospective cross-sectional study. We …

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Diagnostic value of [⁶⁸Ga]Ga-FAPI PET imaging in patients with sarcoma

Cansu Güneren, Lebriz Uslu, Onur Erdem Şahin, Ayşe Mine Önenerk Men et autres

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CD34-Stained Microvessel Density and Immune Checkpoint Inhibitor Outcomes in Metastatic Non-Squamous Non-Small Cell Lung Cancer: A Retrospective Study

Emir Çerme, Şebnem Batur, Cansu Yol, Eray Öntaş et autres

Background/Objectives: Immune checkpoint inhibitors (ICIs) improve outcomes in metastatic non-squamous non-small cell lung cancer (NSCLC), yet predictive biomarkers remain limited. This study investigated whether CD34-stained microvessel density (MVD) is associated with ICI efficacy. Methods: Patients with metastatic non-squamous NSCLC and tumor specimen …

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Unmasking intratumoral heterogeneity: Postoperative revelation of subclonal divergence in de novo metastatic HR‑positive/HER2‑negative breast cancer: A case report

Zeliha Birsin, Emir Çerme, Ceyda Sönmez Wetherilt, Hande Turna

Intratumoral heterogeneity poses a significant challenge in the management of metastatic hormone receptor-positive (HR + ), human epidermal growth factor receptor 2 (HER2)-negative (HER2 -) breast cancer (BC), as it may contribute to treatment resistance and disease progression.Two cases of de novo …

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Bridging East and West: Real-World Clinicogenomic Landscape of Metastatic NSCLC in Türkiye

Kübra Canaslan, Emre Eken, Mehmet Bilici, Fahriye Merve Balcıoğlu et autres

BACKGROUND/OBJECTIVES: Genomic profiling guides treatment in metastatic non-small-cell lung cancer (mNSCLC), yet country-level data from Türkiye remain limited. METHODS: We retrospectively analyzed consecutive patients with mNSCLC diagnosed between January 2018 and March 2025 across tertiary centers in all seven regions. Variables included …

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Vasculitis associated with nonhematological malignancies

Hande Turna

PURPOSE OF REVIEW: There is a complex relationship between nonhematological malignancies and vasculitis Paraneoplastic vasculitis may present in many different forms. Cancer risk is high in patients with some types of vasculitis. Also, immune checkpoint inhibitors (ICIs) used in treatment of many …

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EP.05.04 SUVmax Predicts Pathologic Complete Response and Survival in Lung Cancer Patients Undergoing Neaodjuvant Treatment

Melek Ağkoç, Hüseyin Melek, Hande Turna, Fazilet Öner Dinçbaş et autres

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MAKYAJ ÜRÜNLERİ VE MİKROBİYAL KONTAMİNASYON: HALK SAĞLIĞI RİSKİ

Gaye Su Yiğit, Gülçin Özcan Ateş, Hande Turna

Clinicopathological features and treatment outcomes of patients with fibrolamellar hepatocellular carcinoma: a retrospective multicenter study

Ali Kaan Güren, Hilal Türkben Polat, Eyüp Çoban, Emir Çerme et autres

BACKGROUND: Fibrolamellar Hepatocellular Carcinoma (FLHCC) is a rare primary liver tumour that is distinct from conventional HCC in both histopathological and clinical features. There is no clear consensus on its treatment. OBJECTIVE: Assess the demographics, prognosis, and treatment— particularly systemic therapies—of FLHCC …

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