Carolyn Gabriel

Anticoagulation Timing in Acute Stroke With Atrial Fibrillation According to Chronic Kidney Disease: The OPTIMAS Trial

Philip S. Nash, Hakim‐Moulay Dehbi, Norin Ahmed, Liz Arram et autres

BACKGROUND: Patients with chronic kidney disease (CKD) are at increased risk of ischemic stroke (IS) and intracerebral hemorrhage, so the safety and efficacy of early direct oral anticoagulant (DOAC) initiation in those with CKD are of clinical relevance. METHODS: OPTIMAS (Optimal Timing …

gb, us, ch, dk, se (code pays fourni par la source)

Successful Treatment of Inverse Psoriasis and Psoriatic Arthritis with Deucravacitinib

C Raphael, Carolyn Gabriel, Y C

The treatment of inverse psoriasis with systemic therapy has not been widely reported, this report revealed the use of deucravacitinib in this condition.

Rhombencephalitis in Pregnancy—A Challenging Case of Probable Listeria Infection

Alison E. P. Ho, Zahirrah Begam Mohamed Rasheed, Jim C. Norman, Carolyn Gabriel et autres

Rhombencephalitis refers to inflammation of the brainstem and cerebellum, and can be caused by infections, autoimmune disorders or paraneoplastic syndromes. The most common infective cause is the bacterium Listeria monocytogenes. Listeria monocytogenes is the predominant species to cause human listeriosis, and is …

gb, my (code pays fourni par la source)

015 Service evaluation: the role of same day emergency care in managing acute neurological presentations

Catherine Hsu, Fatima-Zahra Elrhermoul, Chinedu Maduakor, Alex Everitt et autres

Background and aim During the COVID-19 pandemic, the neurology department at St Mary’s Hospital had to direct the bulk of its acute work to a newly expanded ‘hot clinic’ running Monday to Friday through Same Day Emergency Care (SDEC). Face to face …

gb (code pays fourni par la source)

031 Left internal carotid artery dissection presenting as an isolated left hypoglossal nerve palsy

Georgina Hanbury, Aravindhan Baheerathan, Stephen D. Auger, Maneesh C. Patel et autres

A 33 year old male with no significant past medical history presented to the emergency department with an acute onset 4 day history of an odd sensation over his tongue and slurring of his speech. He had noted that his tongue deviated …

gb (code pays fourni par la source)

Cerebral venous thrombosis after vaccination against COVID-19 in the UK: a multicentre cohort study

Richard Perry, Arina Tamborska, Bhagteshwar Singh, Brian Craven et autres

gb (code pays fourni par la source)

Immunosuppression for intracranial vasculitis associated with SARS-CoV-2: therapeutic implications for COVID-19 cerebrovascular pathology

Luke Dixon, Charles Coughlan, Kushan Karunaratne, James Varley et autres

Aims Patients with Trisomy 18 have a poor prognosis – only 5%–10% of children survive beyond the first year; however various clinical features of Trisomy 18 such as gastrointestinal, cardiac and central nervous system anomalies may benefit from surgery. Providing intensive care …

gb (code pays fourni par la source)

Human T-cell lymphotropic virus (HTLV)-associated encephalopathy: an under-recognised cause of acute encephalitis? Case series and literature review

Ania Crawshaw, Divya Dhasmana, Jones Brynmor, Carolyn Gabriel et autres

Human T-cell lymphotropic virus (HTLV)-1-associated myelopathy (HAM) is well described. Clinical features are predominantly consistent with cord pathology, though imaging and autopsy studies also demonstrate brain inflammation. In general, this is subclinical; however, six cases have previously been reported of encephalopathy in …

gb (code pays fourni par la source)

Hard to swallow: atypical transthyretin amyloid neuropathy mistaken for CIDP

Malick M. Gibani, Jonathan Hoare, Carol Whelan, Jason Dungu et autres

In April 2009, a 59-year-old Afro-Caribbean man gave a 6-month history of progressive unsteadiness and falls. He reported heavy legs, tiredness on walking and painless paraesthesia below the knees. There were cramps in his hands, with weakness when attempting to open jars. …

gb (code pays fourni par la source)

A proof of concept study of Infliximab for the treatment of HTLV-1-associated myelopathy

Fabiola Martin, Hannah Castro, Carolyn Gabriel, Adine Adonis et autres

Background Disease modifying treatment options for patients with HAM are limited. Most studies have included all patients regardless of duration, disability or disease activity. The Medical Research Council UK funded a series of proof of concept studies for patients with early (50% …

gb (code pays fourni par la source)

Treatment of patients with HTLV-1-associated myelopathy with methotrexate

Sibtain Ahmed, Adine Adonis, Silva Hilburn, MA Demontis et autres

The lifetime risk of developing HTLV-1 associated myelopathy (HAM) is 0.25-3%. The main pathological feature is an immune-mediated response leading to chronic inflammation of the spinal cord. The optimal long term treatment has yet to be determined although clinical improvement with ciclosporin …

gb (code pays fourni par la source)

Ultrasound-guided lumbar puncture as a diagnostic aid to reduce number of attempts and complication rates

Shohreh Honarbakhsh, Chinar Osman, James Teo, Carolyn Gabriel

Ultrasound-guided lumbar puncture (LP) could be beneficial in situations where anatomical landmarks are difficult to identify. There is some evidence that it is associated with increased success rates and procedural ease. Its effect on complication rates has not been explored. This mixed …

gb (code pays fourni par la source)