Paulina Śliwka

Bacteriophages in the treatment of cutaneous infections and skin disorders: therapeutic advances and future directions

Emilia Hauza, Ivy Mutai, Agnieszka Necel, Deus Kamya et autres

SUMMARY Skin and soft tissue infections represent a major clinical challenge. This is particularly true given the rise in antimicrobial resistance, the increasing prevalence of chronic wounds, and the growing number of immunocompromised patients. Conventional antibiotic therapies are frequently compromised by multidrug-resistant …

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Bacteriophage Therapy: Overcoming Antimicrobial Resistance Through Advanced Delivery Methods

Marcin Wacnik, Emilia Hauza, Aneta Skaradzińska, Paulina Śliwka

Microbial resistance to antibiotics necessitates the development of alternative treatments to address the challenges posed by severe bacterial infections. Bacteriophages are regaining clinical relevance, but the effectiveness of phage therapy depends directly on the route of administration and the carrier used. This …

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Editorial: Phage-based strategies for foodborne pathogen mitigation and detection

Aneta Skaradzińska, Bartłomiej Grygorcewicz, Paulina Śliwka, Robert Czajkowski

Biotechnology of the University of Gdańsk and Medical University of Gdańsk, University of Gdańsk,A. Abrahama 58,Poland The global burden of foodborne illnesses remains a critical public health challenge.According to the World Health Organization (WHO), the consumption of unsafe food results in approximately …

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Statistical Optimization of Bacterial Cellulose Production and Its Application for Bacteriophage Immobilization

Grzegorz Skaradziński, Tomasz Janek, Paulina Śliwka, Aneta Skaradzińska et autres

Bacterial cellulose (BC), an extracellular polysaccharide synthesized by various bacterial strains. It exhibits high tensile strength, water retention, crystallinity, and biocompatibility, making it valuable in biomedical, cosmetic, food, textile, and paper industries. This study examined the effects of six carbon sources on …

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Bacteriophages Improve the Effectiveness of Rhamnolipids in Combating the Biofilm of Candida albicans

Izabela Dusza, Dominika Jama, Grzegorz Skaradziński, Paulina Śliwka et autres

Biofilms formed by Candida albicans pose therapeutic challenges due to their resistance to conventional antimicrobials, highlighting the need for more effective treatments. Rhamnolipids (RLs) are biosurfactants with diverse antimicrobial properties. Bacteriophages are viruses that target specific bacterial strains. Recent studies have shown …

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Application of UPWr_E124 phage cocktail for effective reduction of avian pathogenic Escherichia coli in mice and broiler chickens

David Sáez Moreno, Maciej Kuczkowski, Paweł Korzeniowski, Krzysztof Grzymajło et autres

Avian pathogenic Escherichia coli (APEC) is the main causative agent of colibacillosis, causing poultry respiratory infections, mortality and economic loss. APEC poses a serious threat to public health and food safety due to its multi-drug resistance and capacity to form biofilms. Bacteriophages …

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Avian pathogenic Escherichia coli-targeting phages for biofilm biocontrol in the poultry industry

Paulina Śliwka, David Sáez Moreno, Paweł Korzeniowski, Agata Milcarz et autres

Avian pathogenic Escherichia coli (APEC) is a principal etiologic agent of avian colibacillosis, responsible for significant economic losses in the poultry industry due to high mortality and disease treatment with antibiotics. APEC and its ability to form biofilms on food and processing …

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Bioinorganic Chemistry Meets Microbiology: Copper(II) and Zinc(II) Complexes Doing the Cha-Cha with the C-t-CCL-28 Peptide, Dancing till the End of Microbes

Klaudia Szarszoń, Natalia Baran, Paulina Śliwka, Magdalena Z. Wiloch et autres

High Resolution Image Download MS PowerPoint Slide The necessity to move away from conventional antibiotic therapy has sparked interest in antimicrobial peptides (AMPs). One fascinating example is human CCL-28 chemokine produced by acinar epithelial cells in the salivary glands. It can also …

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Bacteriophages improve the effectiveness of rhamnolipids in combating the biofilm of Candida albicans

Izabela Dusza, Dominika Jama, Grzegorz Skaradziński, Paulina Śliwka et autres

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Metal coordination governs the antimicrobial efficacy of calcitermin derivatives

Silvia Leveraro, Kinga Garstka, Paulina Śliwka, Tomasz Janek et autres

modifications of the native peptide sequence. In this work, the Ala-to-Ser substitutions close to the coordination site of calcitermin have been introduced to study the impact on the biological activity and metal-binding properties. Our results show that metal coordination has a clear …

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Freeze-Drying of Encapsulated Bacteriophage T4 to Obtain Shelf-Stable Dry Preparations for Oral Application

Paulina Śliwka, Grzegorz Skaradziński, Izabela Dusza, Aleksandra Grzywacz et autres

Therapeutic application of bacterial viruses (phage therapy) has in recent years been rediscovered by many scientists, as a method which may potentially replace conventional antibacterial strategies. However, one of the main problems related to phage application is the stability of bacterial viruses. …

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Effective reduction of Salmonella Enteritidis in broiler chickens using the UPWr_S134 phage cocktail

Marta Kuźmińska-Bajor, Paulina Śliwka, Paweł Korzeniowski, Maciej Kuczkowski et autres

Salmonella is a poultry-associated pathogen that is considered one of the most important zoonotic bacterial agents of contaminated food of animal origin including poultry products. Many efforts are taken to eliminate it from the food chain, and phages are one of the …

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