Hamida Abdel‐Hamid

Syntheses, characterization, Hirshfeld analysis, and antioxidant activity of Co(II) and Ag(I) complexes based on oxadiazole ligand

Amal Yousri, Mennatallah Yasser, Saied M. Soliman, David B. Cordes et autres

Égypte, gb, sa (code pays fourni par la source)

Design and synthesis of 1,2,3-triazole thiadiazole hybrids with in vitro and in silico evaluation of their anti-inflammatory and anti-alzheimer activities

Ahmed R. Rabee, Hamida Abdel‐Hamid, Saied M. Soliman, Samah Ashraf et autres

Abstract Nano technology possesses a role in the enhancement of anti-inflammatory and anti-Alzheimer activities of the synthesized triazole/thiadiazole hybrids 3a–c . Selective propargylation of 5-amino-1,3,4-thiadiazole-2-thiol with propargyl bromide and triethyl amine followed by Click reaction with different azides to afford 1,2,3-triazole/thiadiazole hybrids …

Égypte (code pays fourni par la source)

Antioxidant evaluation of novel 3-Aryl-5-phenyloxy-1,2,4-oxadiazoles as radical scavengers: Synthesis, characterization, and ADME studies

Mohammed Salah Ayoup, Islam Shawki, Hamida Abdel‐Hamid, Doaa A. Ghareeb et autres

Cell function depends on redox homeostasis, and several diseases are linked to its disruption. The relative amounts of reduced and oxidised glutathione play a major role in controlling redox balance. Redox equilibrium is essential for a number of physiological functions, including protein …

sa, Égypte (code pays fourni par la source)

Design and synthesis of new 1,2,3-triazole/benzimidazole hybrids using Click reaction: antibacterial evaluation, molecular docking, and DFT analysis

Ahmed R. Rabee, Mohamed Hagar, Saied M. Soliman, Hamida Abdel‐Hamid et autres

Synthesis of innovative 1,2,3-triazole/ benzimidazole hybrids via click reaction. The structure of the synthesized compounds was confirmed based on their spectral data via FT-IR, 1 H-NMR, 13 C-NMR and elemental analysis. The studied compounds were further subjected to molecular docking in the …

Égypte, sa (code pays fourni par la source)

Design, Synthesis, Molecular Docking, and Biological Evaluation of Novel 1,2,4-Oxadiazole-Based Derivatives as Inhibitors of Trypsin, ALDH2, and iNOS

Mohammed Salah Ayoup, Rabia E. Alashhab, Hamida Abdel‐Hamid, Doaa A. Ghareeb et autres

Abstract Objective: A series of novel derivatives based on a 1,2,4-oxadiazole scaffold were designed, synthesized, and evaluated in vitro for their inhibitory activity against trypsin, aldehyde dehydrogenase 2 (ALDH2), and inducible nitric oxide synthase (iNOS), aiming to identify potential anticancer agents. Methods: …

sa, Égypte, Libye, gb (code pays fourni par la source)

Synthesis and characterization of thymol-derived phenoxy acetamide derivatives using DFT, molecular docking, and parasitological investigations

Ahmed R. Rabee, Saied M. Soliman, Hamida Abdel‐Hamid, Esraa Abdelhamid Moneer et autres

Novel phenoxy acetamide derivatives based on a thymol moiety were synthesized for target parasitological investigation. The newly synthesized compounds, 5a, 5b, 7a, 7b, and 9, were synthesized as phenoxy acetamide derivatives containing a phthalimide or naphthalimide ring through a condensation reaction with …

Égypte, sa (code pays fourni par la source)

Nanoformulations for Hydrazones; Synthesis, Characterization, Parasitology, and Histopathology Investigations

Eman M. Hassan, Ahmed R. Rabee, Saied M. Soliman, Mohamed Hagar et autres

High Resolution Image Download MS PowerPoint Slide In the creation of medicine delivery systems, nanotechnology has become an innovator, especially for organic compounds. The manipulation of materials at the nanoscale (1–100 nm) allows for unique physicochemical properties that can enhance the efficacy …

Égypte, us, sa (code pays fourni par la source)

Investigation of Quinoxaline-1,2,3-triazole Derivatives for Targeting SARS-CoV-2 via RBD Binding and PLpro Inhibition

Amr Negm, Ahmad R. Rabee, Hamida Abdel‐Hamid, Samah A. Nasr et autres

Abstract Objective: A library of ten derivatives of 3-benzyl-N1-substituted quinoxalin-2-ones was designed and investigated for targeting SARS-CoV-2. Methods: The target compounds were synthesized as N1-substituted quinoxalines and quinoxaline/triazole hybrids via a click reaction. The anti-SARS-CoV-2 activity of these compounds was evaluated via …

sa, Égypte (code pays fourni par la source)

Investigating the Anticancer Activity of Novel 1,2,4-Oxadiazole-Linked 1,2,3-Triazole Moieties via EGFR/pI3K/mTOR Cascade Down-Regulation

Mohammed Salah Ayoup, Mariam Ghanem, Hamida Abdel‐Hamid, Ibrahim Elghamry et autres

Malignant transformation, apoptosis prevention, drug resistance, and metastasis are all impacted by the EGFR/PI3K/Akt/mTOR pathway. Usually, mutations in lung and colon cancer alter the expression of this pathway. This led to the creation of a new hybrid of 3,5-diaryl-1,2,4-oxadiazole/1,2,3-triazoles. These hybrids were …

sa, Égypte, id (code pays fourni par la source)

Novel Ag(I) and Zn(II) complexes based on benzenesulfonamide ligand: Synthesis, characterization, and biological evaluation as multitarget antidiabetic agents

Mohammed Salah Ayoup, Mennatallah Yasser, Saied M. Soliman, Hamida Abdel‐Hamid et autres

sa, Égypte, gb (code pays fourni par la source)

Dual targeted Ugi-bisamides induce caspase-mediated apoptosis and inhibit PI3K/mTOR signaling in NSCLC

Mohammed Salah Ayoup, Khadiga Yousry, Hamida Abdel‐Hamid, Mohamed S. Nafie et autres

Ugi adduct 8 exhibited potent anti-cancer against NSCLC cancer cells though caspase-mediated apoptosis and PI3K/mTOR inhibition signaling pathway.

sa, Égypte, ae (code pays fourni par la source)

Synthesis, X-ray structure, Hirshfeld analysis and antidiabetic assessment of a novel μ-oxalato Cu(II)-pyrazolone complex

Mohammed Salah Ayoup, Mennatallah Yasser, Saied M. Soliman, Hamida Abdel‐Hamid et autres

sa, Égypte, gb (code pays fourni par la source)