Lingfeng Zeng

Current Status and Review of Traditional Chinese Medicine Formula Granules in the Treatment of Bone and Joint Degenerative Diseases

Zi Wang, Zhang Xian-quan, Zhuoxu Gu, Guang-Hui Zhou et autres

INTRODUCTION: Degenerative bone and joint diseases pose significant challenges in aging societies, causing pain and functional limitations. Traditional Chinese Medicine (TCM) formula granules (TCMFG), which combine traditional efficacy with modern convenience and standardization, represent an important innovative approach to chronic disease management. …

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The role of active constituents of in traditional Chinese medicine for primary osteoporosis: a mechanistic review

Chaoqun Song, Lingfeng Zeng, Changwei Zhao

Primary osteoporosis (POP) is a systemic metabolic bone disorder marked by diminished bone density and deterioration of bone microstructure, presenting a considerable challenge to global public health due to its widespread occurrence and heightened fracture risk. Although conventional western pharmaceutical treatments are …

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Dasatinib and Quercetin alleviate type 2 diabetic osteoporosis by regulating serum metabolite and gut microbiome

Junzheng Yang, Hua Zhang, Zhuoxu Gu, Guanghui Zhou et autres

Type 2 diabetic osteoporosis (T2DOP) is a complex metabolic bone disorder characterized by reduced bone density and increased risk of osteoporosis in patients with type 2 diabetes mellitus. The etiology of T2DOP is multifactorial, involving hyperglycemia, insulin resistance, and gut microbiota dysbiosis. …

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RETRACTED: From molecular mechanism to plant intervention: the bidirectional regulation of inflammation and oxidative stress in bone aging

Qi Li, Xiumei Zhao, Anning Wang, Tingting Hang et autres

This article systematically elaborates the central role of inflammatory response and oxidative stress in osteoporosis (OP) and cartilage injury, and reveals the molecular mechanism by which the two damage bone homeostasis through NF-κB, RANKL and other signaling pathways. Studies have shown that …

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Gynostemma pentaphyllum promotes strained skeletal muscle protein regeneration by adjustment of liver and spleen function via PXR-IL-6-SERCA1a

Yi Zou, Xingqin Wei, Guangying Wu, Dongmei Li et autres

Background Gynostemma pentaphyllum (GYP) is a traditional Chinese medicine (TCM) used for strengthening and injure recovery, previous research has revealed that a 50% ethanol extract of GYP markedly influences strained skeletal muscle regeneration. Further research has clarified that GYP took such effect …

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Research advances in the study of traditional Chinese medicine formula granules on signaling pathway-mediated disease mechanisms

Zhuoxu Gu, Zhonghao Wang, Xianquan Zhang, Guanghui Zhou et autres

As a modern dosage form of traditional Chinese medicine, Traditional Chinese Medicine Formula Granules (TCMFG) maximally retains active metabolites through standardized production processes, including dynamic countercurrent extraction and low-temperature concentration. This serves as a critical material basis for elucidating its multi-target regulatory …

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RETRACTED: Meta-analysis of the synergistic effect of traditional Chinese medicine compounds combined with conventional Western medicine in the treatment of osteoporosis

Huan Jin, Cai Huang, Yan Zhang, Ying Dong et autres

Background: As a global public health problem, osteoporosis (OP) urgently requires better treatment strategies. This study systematically evaluated the synergistic effect of traditional Chinese medicine (TCM) compounds combined with conventional Western medicine (such as bisphosphonates and calcium) compared to Western medicine alone …

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Gusongan capsule enhances osteogenic differentiation to mitigate bone loss in ovariectomized rats via the TLR2/NF-κB pathway

Lingfeng Zeng, Jinlong Zhao, Zhuoxu Gu, Di Zhao et autres

BACKGROUND: Osteoporosis (OP) is a metabolic bone disease characterized by reduced bone mass and impaired bone microstructure, leading to an increased risk of fractures. In this context, the Gusongan (GSA) capsule has gained recognition for its osteogenic potential. PURPOSE: This study sought …

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Fin-R1: A Large Language Model for Financial Reasoning through Reinforcement Learning

Zhaowei Liu, Xin Dong Guo, Fangqi Lou, Lingfeng Zeng et autres

In recent years, general-purpose large language models (LLMs) such as GPT, Gemini, Claude, and DeepSeek have advanced at an unprecedented pace. Despite these achievements, their application to finance remains challenging, due to fragmented data sources, intransparent reasoning processes, and weak transferability to …

The communication role of extracellular vesicles in the osteoarthritis microenvironment

Pu Chen, Lingfeng Zeng, Ting Wang, Jianbo He et autres

Osteoarthritis (OA) is the most common degenerative joint disease worldwide, characterized by synovial inflammation, cartilage loss, and reactive hyperplasia of subchondral bone, affecting the quality of life of hundreds of millions of people. However, the molecular mechanisms underlying the occurrence and progression …

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Effectiveness and Current Status of Icariin in the Treatment of Rotator Cuff Injury Associated with Osteoporosis

Xianquan Zhang, Guanghui Zhou, Zhuoxu Gu, Lingfeng Zeng et autres

Rotator cuff injury is a disease in which the muscle and tendon that constitute the rotator cuff are torn causing shoulder pain and limited function. Osteoporosis (OP) is a systemic metabolic bone disease characterized by decreased bone mass, destruction of bone microstructure, …

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Causes of failed anterior cruciate ligament reconstruction: A retrospective case series

Xiao Jin, Zihan Lin, Meiping Yang, Jinlong Zhao et autres

RATIONALE: The number of anterior cruciate ligament reconstruction (ACLR) surgeries in China is steadily increasing. To enhance the success rate of ACLR, it is crucial to understand the reasons for ACLR failure. The purpose of this study is to determine the primary …

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