Gisah Guilgen

Patterns of use and adherence to breast cancer clinical practice guidelines among Brazilian medical oncologists: The GUIDE-Breast survey (LACOG 0924-GBECAM|D9673N00006).

Giuliano Santos Borges, Tomás Reinert, Gisah Guilgen, Maiane Maria Pauletto et autres

e23146 Background: Clinical practice guidelines are central to standardize breast cancer (BC) care and reduce disparities in outcomes. Understanding their integration into routine practice and the impact of access limitations is essential to guide strategies that improve equity and quality of care …

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Knowledge, attitudes, and factors influencing clinical trial participation among breast cancer patients in Brazil: The LACOG 1123 (ASTRAL) study.

Gisah Guilgen, Débora De Melo Gagliato, Angelica Nogueira Rodrigues, Gustavo Werutsky et autres

e23209 Background: Despite Brazil’s growing participation in clinical cancer research, data on knowledge, attitudes, and factors influencing clinical trial participation remain limited. The LACOG 1123 (ASTRAL) study evaluated these aspects among Brazilian patients with breast cancer (BC). Methods: Patients ≥18 years diagnosed …

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Trust, ethics, and patient engagement in clinical research: Findings from the LACOG 1123 ASTRAL survey in Brazil.

Gisah Guilgen, Débora De Melo Gagliato, Angelica Nogueira Rodrigues, Daniela Dornelles Rosa et autres

e23171 Background: Trust, ethical understanding, and engagement are critical determinants of successful and equitable clinical research. However, limited data describe how individuals with cancer perceive ethical safeguards, voluntariness, and their potential role in the design of clinical trials, particularly in middle-income countries. …

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Presenting the Brazilian physical activity during cancer treatment guidelines: adaptations and challenges in a low- and middle-income context

Rafael Deminice, Fábio Fortunato Brasil de Carvalho, Leandro F. M. Rezende, Gisah Guilgen et autres

BACKGROUND: The purpose of this article is to present the Brazilian Physical Activity (PA) During Cancer Treatment Guidelines(PA) during cancer treatment, and discuss the adaptations made to align the recommendations with the Brazilian context and its distinctive peculiarities. METHODS: The development of …

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Recomendações Brasileiras de Atividade Física para Prevenir e Controlar o Câncer

Rafael Deminice, Fábio Fortunato Brasil de Carvalho, Leandro F. M. Rezende, Patrı́cia C. Brum et autres

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Abstract OT2-22-02: Sequencing of anthracyclines and taxanes during neoadjuvant therapy of locally advanced HER2-negative breast cancer (NEOSAMBA Study/LACOG 0419)

Tomás Reinert, Cristiano de Pádua Souza, Pedro Emanuel Rubini Liedke, Gustavo Werutsky et autres

Abstract Background: Breast cancer (BC) is the most frequent cancer in women in Brazil, with more than 60,000 cases estimated annually. Forty percent of patients present with stages III and IV and neoadjuvant chemotherapy (NACT) remains the mainstay of treatment for locally …

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Impact of COVID-19 Disease in Early Breast Cancer Management: A Summary of the Current Evidence

Francisco Pimentel Cavalcante, Edson Abdala, Leonardo Weissmann, Carlos Eduardo dos Santos Ferreira et autres

PURPOSE: An expert panel on breast cancer and COVID-19 disease was convened to address the impact of the COVID-19 pandemic for early breast cancer (eBC) management. METHODS: To ensure that the most clinically relevant information was addressed, essential information was drawn from …

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Cost-effectiveness of ribociclib for premenopausal or perimenopausal women with HR+/HER2− advanced breast cancer: a Brazilian public health care system perspective

Daniela Dornelles Rosa, Carlos Alberto da Silva Magliano, Sergio Daniel Simon, Gilberto Luiz da Silva Amorim et autres

Introduction: The MONALEESA-7 trial compared ribociclib plus endocrine therapy (ET) with placebo as first-line treatment of advanced luminal/HER2-negative breast cancer (ABC) in premenopausal and perimenopausal women (age <50 years) and showed significant benefits to progression-free survival and overall survival. This study aimed …

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Impact of COVID-19 in early breast cancer management: a summary of the current evidence

Francisco Pimentel Cavalcante, Edson Abdala, Leonardo Weissmann, Carlos Eduardo dos Santos Ferreira et autres

Purpose : An Expert Panel on Breast Cancer and COVID-19 was convened to address the impact of the COVID-19 pandemic for early breast cancer management. Methods : In order to ensure the most clinically relevant information was addressed, essential information was drawn …

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Preference for the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection in patients with HER2-positive early breast cancer (PHranceSCa): A randomised, open-label phase II study

Joyce A O'Shaughnessy, Susana Gama de Sousa, Josefina Cruz, Lesley J. Fallowfield et autres

AIM: The aim of the study was to assess patient preference for the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection (PH FDC SC) in patients with HER2-positive early breast cancer in PHranceSCa (NCT03674112). MATERIALS AND METHODS: Patients who completed neoadjuvant …

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Reviewing the Role of Aspirin in Chemoprevention of Colorectal Cancer

Gisah Guilgen

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Increased Calcification and Protein Nitration in Arteries of Chronic Kidney Disease Patients

Gisah Guilgen, Marília Lacerda Werneck, Lúcia de Noronha, Ana Paula Camargo Martins et autres

BACKGROUND: Cardiovascular disease in chronic kidney disease (CKD) has peculiar characteristics. The aim of this study was to analyze atherosclerosis, vascular calcification and nitration in arteries from CKD patients. METHODS: External iliac and renal artery segments from 27 stage 5 CKD patients …

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