Aya Kobayashi

Single-Cell Multiomics Reveals Novel Immune Cell Signatures Associated with Early Alzheimer's Disease

Hiroshi Nakamura, Yuki Tanaka, Aya Kobayashi

Background Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and a leading cause of dementia worldwide. Increasing evidence indicates that immune dysregulation and chronic neuroinflammation are fundamental contributors to disease initiation and progression, preceding overt neuronal degeneration. Conventional molecular approaches have …

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CX3CR1-Dependent Macrophages Drive Ovarian Cancer Progression Through MMP-2 and TGF-β Production

Yuko Tanizaki-Horiuchi, Yuko Ishida, Aya Kobayashi, Tamaki Yahata et autres

Background: Epithelial ovarian cancer (EOC) is characterized by aggressive peritoneal dissemination and an immunosuppressive tumor microenvironment in which tumor-associated macrophages (TAMs) play a central role. Chemokine signaling pathways regulate macrophage recruitment and function; however, the contribution of the CX3CL1–CX3CR1 axis to ovarian …

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Serum-Derived Macrophage-Activating Factor Exhibits Anti-Tumor Activity via M2-to-M1 Macrophage Reprogramming

Tsuyoshi Takara, Rei Takara, Aya Kobayashi, Hina Shirakata et autres

Many anti-tumor effects of group-specific component-derived macrophage-activating factors (GcMAFs) have been reported; however, the specific mechanisms remain unclear. Controlling tumor-associated macrophages (TAMs) in the tumor microenvironment is essential for cancer treatment. This study assessed the role of GcMAF in macrophage activation, elucidated …

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Serum-Derived Macrophage-Activating Factor Exhibits Anti-Tumor Activity via M2-to-M1 Macrophage Reprogramming

Tsuyoshi Takara, Rei Takara, Aya Kobayashi, Hina Shirakata et autres

Many anti-tumor effects of group-specific component-derived macrophage-activating factors (GcMAFs) have been reported; however, the specific mechanisms remain unclear. Controlling tumor-associated macrophages (TAMs) in the tumor microenvironment is essential for cancer treatment. This study assessed the role of GcMAF in macrophage activation, elucidated …

jp (code pays fourni par la source)

Data from RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

Megumi Iiizumi, Sucharita Bandyopadhyay, Sudha K. Pai, Misako Watabe et autres

Abstract RhoC is a member of the Ras-homologous family of genes which have been implicated in tumorigenesis and tumor progression. However, the exact role of RhoC is controversial and is yet to be clarified. We have examined the effect of RhoC on …

Supplementary Figure 1 from RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

Megumi Iiizumi, Sucharita Bandyopadhyay, Sudha K. Pai, Misako Watabe et autres

Supplementary Figure 1 from RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

Supplementary Figure 2 from RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

Megumi Iiizumi, Sucharita Bandyopadhyay, Sudha K. Pai, Misako Watabe et autres

Supplementary Figure 2 from RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

Supplementary Methods, Figures 1-7, Tables 1-7 from Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem–Like Cells with Macrophages and Stromal Cells

Hiroshi Okuda, Aya Kobayashi, Bo Xia, Misako Watabe et autres

PDF file - 2.6MB

Supplementary Figure 1 from RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

Megumi Iiizumi, Sucharita Bandyopadhyay, Sudha K. Pai, Misako Watabe et autres

Supplementary Figure 1 from RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

Supplementary Figure 2 from RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

Megumi Iiizumi, Sucharita Bandyopadhyay, Sudha K. Pai, Misako Watabe et autres

Supplementary Figure 2 from RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

Supplementary Methods, Figures 1-7, Tables 1-7 from Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem–Like Cells with Macrophages and Stromal Cells

Hiroshi Okuda, Aya Kobayashi, Bo Xia, Misako Watabe et autres

PDF file - 2.6MB

Data from Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem–Like Cells with Macrophages and Stromal Cells

Hiroshi Okuda, Aya Kobayashi, Bo Xia, Misako Watabe et autres

Abstract The molecular mechanisms that operate within the organ microenvironment to support metastatic progression remain unclear. Here, we report that upregulation of hyaluronan synthase 2 (HAS2) occurs in highly metastatic breast cancer stem–like cells (CSC) defined by CD44+/CD24−/ESA+ phenotype, where it plays …