Claudia Schulte

Exploring TIMP2 genetics and CSF levels in Parkinson’s disease: biomarkers of neurodegeneration and ageing

Milan Zimmermann, Madeleine Fandrich, Claudia Schulte, Meike Jakobi et autres

de (code pays fourni par la source)

Welfare-Based Healthcare Planning: Methodology and Application to Thoracic Surgical Treatment of Lung Cancer in Germany

Martin Roessler, Laura Elizabeth Korthauer, Isabelle Petrautzki, Christoph Bobeth et autres

de (code pays fourni par la source)

TMEM175, SCARB2 and CTSB associations with Parkinson’s disease risk across populations

Wen-Hua Sun, Claudia Schulte, Thomas Gasser, Manuela M. X. Tan et autres

Genome-wide association study of Parkinson's disease (PD) identified common variants associated with lysosomal mechanism, including TMEM175, SCARB2, and CTSB. We investigated the association between common and rare variants across populations using cohorts from the Global Parkinson's Genetics Program (GP2) (33,733 cases and …

de, no, cl, us, gb, Nigéria, br, ar, au, at, ca, cn, hk, co, cr, Égypte, Éthiopie, fr, Ghana, gr, hn, in, ir, it, jp, kg, lu, my (code pays fourni par la source)

Understanding the pattern of cognitive decline in GBA1-related Parkinson’s Disease: a longitudinal multi-cohort study

Merle Bode, Claire Pauly, Sonja R. Jónsdóttir, Claudia Schulte et autres

Abstract Objective People with Parkinson’s disease (PD) who carry a pathogenic GBA1 variant (PD GBA1 ) are at higher risk of cognitive impairment than those without the variant (PD GBA1_wildtype ). To date, little is known about the pattern and evolution of …

de, lu, ca, at (code pays fourni par la source)

Quantification of cerebrospinal fluid α-synuclein seeds by endpoint dilution seed amplification assay in Parkinson’s disease

Kathrin Brockmann, Alice Ticca, Stefanie Lerche, Andrea Mastrangelo et autres

Quantitative pathology-specific biomarkers are needed for patients with Parkinson's disease (PD). We estimated the α-syn seeding dose giving 50% of positive seed amplification assay (SAA) reactions (SD50) in serially diluted samples from 260 PD participants, of whom 54 had longitudinal samples. We …

de, it, ca (code pays fourni par la source)

TMEM175, SCARB2 and CTSB associations with Parkinson’s disease risk across populations

Wen-Hua Sun, Claudia Schulte, Thomas Gasser, Manuela M. X. Tan

Abstract Genome-wide association study of Parkinson’s disease (PD) identified common variants associated with lysosomal mechanism, including TMEM175, SCARB2 , and CTSB . We investigated the association between common and rare variants across populations using cohorts from the Global Parkinson’s Genetics Program (GP2) …

de, no (code pays fourni par la source)

DNA Isolation from EDTA-blood v1

Ann‐Kathrin Hauser, Claudia Schulte

Whole blood collected in EDTA vials (9-10mL) is processed to remove the erythrocytes before salting out the total DNA for long term storage at 4 deg C.

de (code pays fourni par la source)

Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseases

Milan Zimmermann, Madeleine Fandrich, Meike Jakobi, Benjamin Röeben et autres

Parkinson's disease (PD) exhibits substantial phenotypic variability, likely influenced, at least in part, by proteins associated with pathways integral to aging processes. Plasminogen activator inhibitor-1 (SERPIN E1) is known for its association with aging processes and exacerbated α-Synuclein pathology. We examined whether …

de (code pays fourni par la source)

Impact of lifestyle factors on quantitative motor and cognitive performance: insights from a longitudinal study on healthy ageing

Milan Zimmermann, Ulrike Suenkel, Isabel Wurster, Stefanie Lerche et autres

de (code pays fourni par la source)

Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins

Georgy Berezhnoy, Gyuntae Bae, Leonie Wüst, Claudia Schulte et autres

The challenge of early detection and stratification in Parkinson's disease (PD) is urgent due to the current emergence of mechanism-based disease-modifying treatments. In here, metabolomic and lipidomic parameters obtained by a standardized and targeted in vitro diagnostic research (IVDr) platform have a …

de, us, gb (code pays fourni par la source)

Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants

Stefanie Lerche, Isabel Wurster, Benjamin Röeben, Milan Zimmermann et autres

Abstract We studied the age- and genetic-related prevalence of CSF alpha-Synuclein seeding and Alzheimer profiles in 188 samples from PD participants without GBA1 variants (PDwildtype) and in 129 samples from PD participants with GBA1 variants (PDGBA1). While Alzheimer profiles increased with age …

de, ca, it (code pays fourni par la source)

Welfare-based healthcare planning: methodology and application to thoracic surgical treatment of lung cancer in Germany

Martin Roessler, Laura Elizabeth Korthauer, Isabelle Petrautzki, Christoph Bobeth et autres

de (code pays fourni par la source)