Joanna Szafraniec-Szczęsny

Is PVP K-29/32 an Efficient Stabilizing Excipient in Amorphous Solid Dispersions Containing the Poorly Water-Soluble Drug—Bicalutamide?

Agata Antosik-Rogóż, Joanna Szafraniec-Szczęsny, Karolina Gawlak, Aleksander Mendyk

The stability of amorphous drug substances is a crucial issue in the pharmaceutical field. This study examines the influence of polyvinylpyrrolidone as an excipient on the stabilization of the amorphous drug substance bicalutamide. Solid dispersions of the active substance and the excipient …

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Physically Cross-Linked PVA Hydrogels as Potential Wound Dressings: How Freezing Conditions and Formulation Composition Define Cryogel Structure and Performance

Anna Górska, Ewelina Baran, Justyna Knapik-Kowalczuk, Joanna Szafraniec-Szczęsny et autres

Objectives: Hydrogels produced using the freeze–thaw method have demonstrated significant potential for wound management applications. However, their production requires precise control over critical factors including freezing temperature and the choice of matrix-forming excipients, for which no consensus on the optimal conditions currently …

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The Influence of Hydrogen on Structural and Magnetic Transformations in RMn2Hx Hydrides with Laves Phase C15 and C14 Structures—A Review

A. Budziak, Joanna Szafraniec-Szczęsny

Laves phases crystallize in simple structures and are very common intermetallic phases that can form from combinations of elements throughout the periodic table, giving a huge number of known examples. A special feature of AB2 or AB5 phases is the ability to …

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Investigating the Impact of Co-processed Excipients on the Formulation of Bromhexine Hydrochloride Orally Disintegrating Tablets (ODTs)

Krzysztof Woyna-Orlewicz, Witold Brniak, Wiktor Tatara, Magdalena Strzebońska et autres

PURPOSE: Orodispersible tablets (orally disintegrating tablets, ODTs) have been used in pharmacotherapy for over 20 years since they overcome the problems with swallowing solid dosage forms. The successful formula manufactured by direct compression shall ensure acceptable mechanical strength and short disintegration time. …

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Study of the Effect of Eudragit RSPO on the Photostability of Venlafaxine in a Physical Mixture and in a Melt Form

Anna Maślanka, Marek Szlósarczyk, Przemysław Talik, Joanna Szafraniec-Szczęsny et autres

The effect of Eudragit RSPO on the photostability of venlafaxine in a physical mixture and as a melt was studied. A validated ultra-high-performance liquid chromatography mass spectrometry method was used to determine the content of venlafaxine alongside degradation products. The most likely …

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How Does Long-Term Storage Influence the Physical Stability and Dissolution of Bicalutamide from Solid Dispersions and Minitablets?

Agata Antosik-Rogóż, Joanna Szafraniec-Szczęsny, Justyna Knapik-Kowalczuk, Mateusz Kurek et autres

The stability of amorphous drugs is among the main challenges in the development of solid dosage forms. This paper examines the effect of storage conditions (25 °C/60% RH and 40 °C/75% RH) and different packaging materials, i.e., polystyrene containers and PVC/Al blisters, …

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The Impact of the Preparation Method on the Properties of Orodispersible Films with Aripiprazole: Electrospinning vs. Casting and 3D Printing Methods

Ewelina Łyszczarz, Witold Brniak, Joanna Szafraniec-Szczęsny, Tomasz M. Majka et autres

Orodispersible films (ODFs) address the needs of pediatric and geriatric patients and people with swallowing difficulties due to fast disintegration in the mouth. Typically, they are obtained using the solvent casting method, but other techniques such as 3D printing and electrospinning have …

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How to Obtain the Maximum Properties Flexibility of 3D Printed Ketoprofen Tablets Using Only One Drug-Loaded Filament?

Jolanta Pyteraf, Witold Jamróz, Mateusz Kurek, Joanna Szafraniec-Szczęsny et autres

The flexibility of dose and dosage forms makes 3D printing a very interesting tool for personalized medicine, with fused deposition modeling being the most promising and intensively developed method. In our research, we analyzed how various types of disintegrants and drug loading …

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Hyaluronic Acid-Based Nanocapsules as Efficient Delivery Systems of Garlic Oil Active Components with Anticancer Activity

Małgorzata Janik-Hazuka, Kamil Kamiński, Marta Kaczor-Kamińska, Joanna Szafraniec-Szczęsny et autres

Diallyl disulfide (DADS) and diallyl trisulfide (DATS) are garlic oil compounds exhibiting beneficial healthy properties including anticancer action. However, these compounds are sparingly water-soluble with a limited stability that may imply damage to blood vessels or cells after administration. Thus, their encapsulation …

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Erratum to “How can we improve the physical stability of co-amorphous system containing flutamide and bicalutamide? The case of ternary amorphous solid dispersions” [Eur. J. Pharmaceut. Sci. 136 (2019) 104947]

Justyna Pacułt, Marzena Rams‐Baron, Krzysztof Chmiel, Karolina Jurkiewicz et autres

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How can we improve the physical stability of co-amorphous system containing flutamide and bicalutamide? The case of ternary amorphous solid dispersions.

Justyna Pacułt, Marzena Rams‐Baron, Krzysztof Chmiel, Karolina Jurkiewicz et autres

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Low Dose Curcumin Administered in Hyaluronic Acid-Based Nanocapsules Induces Hypotensive Effect in Hypertensive Rats

Izabela Czyżyńska-Cichoń, Małgorzata Janik-Hazuka, Joanna Szafraniec-Szczęsny, K Jasiński et autres

Background: Vascular drug delivery becomes a promising direction in the development of novel therapeutic strategies in the treatment of cardiovascular pathologies, such as hypertension. However, targeted delivery of hydrophobic substances, with poor bioavailability, remains a challenge. Here, we described the hypotensive effects …

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