Burcu Parlak

Ceftazidime-avibactam as a polymyxin-sparing option for multidrug-resistant Gram-negative infections in children: a real-world comparative cohort study

Sevgi Aslan Tuncay, Gülşen Akkoç, Ezgi Celikboya, Seyhan Yilmaz et autres

Multidrug-resistant (MDR) Gram-negative infections are challenging to treat in children, and polymyxin-based regimens are limited by toxicity. We evaluated the real-world use of ceftazidime-avibactam (CZA) as a potential polymyxin-sparing option for children with MDR Gram-negative infections. We conducted a single-center retrospective comparative …

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Childhood Tuberculosis Following Household Exposure: Risk Factors and Clinical Outcomes from a Retrospective Cohort

Gülşen Akkoç, S Yilmaz, Sevgi Aslan Tuncay, Aylin Dizi Işık et autres

Background: Tuberculosis (TB) remains a major cause of morbidity and mortality, with children primarily infected through close contact with adults. Data on household transmission in children in Türkiye are limited.Objective: This study aimed to determine the prevalence of latent t.u.berculosis infection (LTBI) …

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Pediatric saprochaete infections: insights from case reports

Sevgi Aslan Tuncay, Gülşen Akkoç, Zeynep Ergenç, S Yilmaz et autres

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Pediatric fever of unknown origin: Diagnostic spectrum revealed by a multidisciplinary retrospective study

Aylin Dizi Işık, Gülşen Akkoç, S Yilmaz, Sevgi Aslan Tuncay et autres

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Invasive Mould Infections in Chronic Granulomatous Disease: A Multicenter Study From Türkiye

Zeynep Ergenç, Sevgi Bilgiç Eltan, Betül Gemici Karaaslan, Ayça Kıykım et autres

BACKGROUND: Chronic Granulomatous Disease (CGD) is a rare primary immunodeficiency, predisposing to life-threatening invasive mould infection (IMI). While antifungal prophylaxis has improved outcomes, IMI remains the leading cause of mortality in CGD. This study aimed to evaluate the clinical and fungal epidemiology …

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An Escherichia coli pseudo-outbreak in the intensive care units of a university hospital

Burcu Parlak, Sevliya Öcal Demi̇r, S Yilmaz, Sevgi Aslan Tuncay et autres

BACKGROUND: The term 'pseudo-outbreak' refers to a condition in which a microorganism is found in cultures at a greater rate than expected due to contamination of materials that would normally be sterile. This situation cannot be clinically correlated with the infection suggested …

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Pediatric Gram-negative bloodstream infections: epidemiology, antibiotic resistance, clinical outcomes and factors affecting mortality, a single center retrospective study

S Yilmaz, Gülşen Akkoç, Sevgi Aslan Tuncay, Burcu Parlak et autres

INTRODUCTION: The increasing prevalence of Gram-negative bloodstream infections in pediatric patients poses significant treatment challenges, particularly from multi-drug resistant (MDR) strains. Despite advances in medical care, mortality from bloodstream infections remains a concern. Our study aims to understand pediatric patients` demographics, clinical …

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Listeria Meningitis as an Indication of Undiagnosed Primary Immune Deficiency, Activated Phosphoinositide 3-Kinase Delta Syndrome: A Case Report

Pınar Canizci Erdemli, Sevliya Öcal Demi̇r, Selcen Bozkurt, Sevgi Aslan Tuncay et autres

INTRODUCTION: Listeria monocytogenes is a Gram-positive bacillus that causes severe infections mainly in newborns, pregnant women, immunocompromised individuals, and elderly. In this report, we present a case of immune dysregulation that presented with invasive Listeria infection despite the absence of these risk …

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The assessment of exhaled nitric oxide in patients with obesity and asthma before and after exercise

Burcu Parlak, Zeynep Tamay, Nermin Güler

OBJECTIVE: It is well-known that children who suffer from obesity and asthma may also have exercise-induced bronchospasm. Exhaled nitric oxide is an indicator of airway inflammation, and could be affected by exercise. This study looked at how exercise, which is a typical …

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Case Report: Brucellosis Mimicking Tuberculous Meningitis in a Child

Sevgi Aslan Tuncay, Gülşen Akkoç, Seyhan Yılmaz, Burcu Parlak et autres

Neurobrucellosis is rare in children, presenting with a variety of clinical manifestations, including meningitis, meningoencephalitis, cranial neuropathies, and intracranial mass-like lesions. We present a case of a 17-year-old girl admitted to the hospital in Istanbul for headache. Lumbar puncture showed elevated intracranial …

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Where is the Human Papillomavirus vaccine heading? A Review

Burcu Parlak

DNA onkojenik virüsleri arasında kutanöz ve mukozal yüzeylerde epitel proliferasyona neden olan Human papillomavirus bulunur. Human papillomavirus, cinsel yolla bulaşan en yaygın enfeksiyondur. Cilt veya mukoza arasındaki temas yoluyla yayılır, ayrıca kutanöz veya mukozal hasar yoluyla vücuda girer. Doğum sırasında anneden bebeğe …

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The use of fosfomycin in infections caused by multidrug-resistant pathogens, especially pneumonia in children: a five-year retrospective single-centre experience

Aylin Dizi Işık, Gülşen Akkoç, Zeynep Ergenç, S Yilmaz et autres

BACKGROUND: Fosfomycin is gaining increasing attention for its activity against MDR or XDR pathogens. Currently, IV fosfomycin is a potential option for treating various infections, including urinary tract infections, pneumonia and skin infections when first-line treatments fail. OBJECTIVES: To evaluate the demographic, …

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