Clive R. Wood

Imputation of structural variants using a multi-ancestry long-read sequencing panel enables identification of disease associations

Boris Noyvert, A Mesut Erzurumluoglu, Dmitriy Drichel, Steffen Omland et autres

Advancements in long-read sequencing technology have accelerated the study of large structural variants (SVs). We created a curated, publicly available, multi-ancestry SV imputation panel by long-read sequencing 888 samples from the 1000 Genomes Project. This high-quality panel was used to impute SVs …

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Imputation of structural variants using a multi-ancestry long-read sequencing panel enables identification of disease associations

Boris Noyvert, Abdullah Mesut Erzurumluoglu, Dmitriy Drichel, Steffen Omland et autres

Advancements in long-read sequencing technology have accelerated the study of large structural variants (SVs). We created a curated, publicly available, multi-ancestry SV imputation panel by long-read sequencing 888 samples from the 1000 Genomes Project. This high-quality panel was used to impute SVs …

us, au, gb, de, in (code pays fourni par la source)

Imputation of structural variants using a multi-ancestry long-read sequencing panel enables identification of disease associations

Boris Noyvert, Abdullah Mesut Erzurumluoglu, Dmitriy Drichel, Steffen Omland et autres

Abstract Advancements in long-read sequencing technology have accelerated the study of large structural variants (SVs). We created a curated, publicly available, multi-ancestry SV imputation panel by long-read sequencing 888 samples from the 1000 Genomes Project. This high-quality panel was used to impute …

us, au, gb, de, in (code pays fourni par la source)

Imputation of structural variants using a multi-ancestry long-read sequencing panel enables identification of disease associations

Boris Noyvert, Abdullah Mesut Erzurumluoglu, Dmitriy Drichel, Steffen Omland et autres

Abstract Advancements in long-read sequencing technology have accelerated the study of large structural variants (SVs). We created a curated, publicly available, multi-ancestry SV imputation panel by long-read sequencing 888 samples from the 1000 Genomes Project. This high-quality panel was used to impute …

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Data from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra et autres

Abstract Inhibition of specific matrix metalloproteinases (MMP) is an attractive noncytotoxic approach to cancer therapy. MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role in tumor growth, invasion, and neovascularization. Besides cleaving matrix proteins, MMP-14 activates proMMP-2 leading …

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Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra et autres

Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Supplementary Tables1-2 from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra et autres

Supplementary Tables1-2 from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Supplementary Tables1-2 from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra et autres

Supplementary Tables1-2 from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra et autres

Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Data from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra et autres

Abstract Inhibition of specific matrix metalloproteinases (MMP) is an attractive noncytotoxic approach to cancer therapy. MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role in tumor growth, invasion, and neovascularization. Besides cleaving matrix proteins, MMP-14 activates proMMP-2 leading …

opnMe.com: a digital initiative for sharing tools with the biomedical research community

Andreas Gollner, Markus Köster, Paul L. Nicklin, Thomas Trieselmann et autres

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Fully Human Monoclonal Antibody Inhibitors of the Neonatal Fc Receptor Reduce Circulating IgG in Non-Human Primates

Andrew E. Nixon, Jie Chen, Daniel J. Sexton, Arumugam Muruganandam et autres

The therapeutic management of antibody-mediated autoimmune disease typically involves immunosuppressant and immunomodulatory strategies. However, perturbing the fundamental role of the neonatal Fc receptor (FcRn) in salvaging IgG from lysosomal degradation provides a novel approach - depleting the body of pathogenic immunoglobulin by …

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