Davoud Mohtat

Moving the neonatal nephrology field forward: results from the Pediatric Academic Society Neonatal Nephrology Focus Group

Cara L. Slagle, Shina Menon, David T. Selewski, Michelle C. Starr et autres

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Development of an adaptive clinical web-based prediction tool for kidney replacement therapy in children with chronic kidney disease

Derek K. Ng, Matthew B. Matheson, George J. Schwartz, Frances M. Wang et autres

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Supplementary Tables 1 - 6 from Kidney Cancer Is Characterized by Aberrant Methylation of Tissue-Specific Enhancers That Are Prognostic for Overall Survival

Caroline Y. Hu, Davoud Mohtat, Yiting Yu, Yi‐An Ko et autres

PDF file - 77K, Supplementary Table 1: Clinical and Pathological characteristics of tumor samples. Supplementary Table 2: Aberrantly methylated and underexpressed loci with overlapping enhancer (H3K4me1) marks. Supplementary Table 3: Transcription factor binding sites enriched in differentially methylated regions in RCC. Supplementary …

Data from Kidney Cancer Is Characterized by Aberrant Methylation of Tissue-Specific Enhancers That Are Prognostic for Overall Survival

Caroline Y. Hu, Davoud Mohtat, Yiting Yu, Yi‐An Ko et autres

Abstract Purpose: Even though recent studies have shown that genetic changes at enhancers can influence carcinogenesis, most methylomic studies have focused on changes at promoters. We used renal cell carcinoma (RCC), an incurable malignancy associated with mutations in epigenetic regulators, as a …

Data from Kidney Cancer Is Characterized by Aberrant Methylation of Tissue-Specific Enhancers That Are Prognostic for Overall Survival

Caroline Y. Hu, Davoud Mohtat, Yiting Yu, Yi‐An Ko et autres

Abstract Purpose: Even though recent studies have shown that genetic changes at enhancers can influence carcinogenesis, most methylomic studies have focused on changes at promoters. We used renal cell carcinoma (RCC), an incurable malignancy associated with mutations in epigenetic regulators, as a …

Supplementary Tables 1 - 6 from Kidney Cancer Is Characterized by Aberrant Methylation of Tissue-Specific Enhancers That Are Prognostic for Overall Survival

Caroline Y. Hu, Davoud Mohtat, Yiting Yu, Yi‐An Ko et autres

PDF file - 77K, Supplementary Table 1: Clinical and Pathological characteristics of tumor samples. Supplementary Table 2: Aberrantly methylated and underexpressed loci with overlapping enhancer (H3K4me1) marks. Supplementary Table 3: Transcription factor binding sites enriched in differentially methylated regions in RCC. Supplementary …

Revisiting the Application of an Adult Kidney Failure Risk Prediction Equation to Children With CKD

Gayathri Menon, Christopher B. Pierce, Derek K. Ng, Sahar A. Fathallah-Shaykh et autres

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Recurrent Hemolysis in a Child With Shiga Toxin-Producing Escherichia coli and Two Heterozygous Variants Associated With Atypical Hemolytic Uremic Syndrome

Priyanka Chati, Davoud Mohtat, Patricia W. Seo-Mayer

Introduction: The most common cause of hemolytic uremic syndrome in children is shiga toxin-producing E. coli (STEC-HUS). We report a patient with STEC-HUS who had an unusually persistent course, leading to discovery of two heterozygous gene variants associated with atypical HUS (aHUS). …

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Kidney Cancer Is Characterized by Aberrant Methylation of Tissue-Specific Enhancers That Are Prognostic for Overall Survival

Caroline Y. Hu, Davoud Mohtat, Yiting Yu, Yi-An Ko et autres

PURPOSE: Even though recent studies have shown that genetic changes at enhancers can influence carcinogenesis, most methylomic studies have focused on changes at promoters. We used renal cell carcinoma (RCC), an incurable malignancy associated with mutations in epigenetic regulators, as a model …

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Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development

Yi-An Ko, Davoud Mohtat, Masako Suzuki, Ae Seo Deok Park et autres

BACKGROUND: One in eleven people is affected by chronic kidney disease, a condition characterized by kidney fibrosis and progressive loss of kidney function. Epidemiological studies indicate that adverse intrauterine and postnatal environments have a long-lasting role in chronic kidney disease development. Epigenetic …

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Transcriptome Analysis of Human Diabetic Kidney Disease

Karolina I. Woroniecka, Ae Seo Deok Park, Davoud Mohtat, David B. Thomas et autres

OBJECTIVE: Diabetic kidney disease (DKD) is the single leading cause of kidney failure in the U.S., for which a cure has not yet been found. The aim of our study was to provide an unbiased catalog of gene-expression changes in human diabetic …

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High-resolution methylome analysis of renal cell carcinoma and identification of aberrant epigenetic changes in gene bodies.

Chanyue Hu, Davoud Mohtat, Yiting Yu, Tushar Damodar Bhagat et autres

e15000 Background: Metastatic renal cell carcinoma (RCC) has a very poor prognosis with limited therapeutic options. Despite this, there have been very few global genetic and epigenetic studies of RCC. DNA methylation is an epigenetic change that has been extensively studied in …