Lukas Nägeli

Heterologous pulcherrimin production in Saccharomyces cerevisiae confers inhibitory activity on Botrytis conidiation

Florian M. Freimoser, Marina Mahler, Mark McCullough, Alexander O. Brachmann et autres

Pulcherrimin is an iron (III) chelate of pulcherriminic acid that plays a role in antagonistic microbial interactions, iron metabolism, and stress responses. Some bacteria and yeasts produce pulcherriminic acid, but so far, pulcherrimin could not be produced in Saccharomyces cerevisiae. Here, multiple …

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Genome sequence data of the strongly antagonistic yeast Pichia kluyveri isolate APC 11.10 B as a foundation for analysing biocontrol mechanisms

Lukas Nägeli, Martin Schüler, Tina Segessemann, Daniel Frei et autres

Pichia kluyveri strain APC 11.10 B was isolated from apple bark in Switzerland and exhibited strong antagonistic activity against plant pathogenic fungi in vitro (e.g., Botrytis, Fusarium or Monilinia isolates). In order to identify the mechanisms underlying this antagonism, we have sequenced …

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Clinical Aureobasidium Isolates Are More Fungicide Sensitive than Many Agricultural Isolates

Electine Magoye, Lukas Nägeli, Andreas Bühlmann, Maja Hilber-Bodmer et autres

Environmental microbiota are regularly found in clinical samples and can cause disease, in particular, in immunocompromised individuals. Organisms of the genus Aureobasidium belonging to this group are highly abundant, and some species are even described as pathogens.

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Genome Sequence Data of the Strongly Antagonistic Yeast Pichia Kluyveri Isolate APC 11.10 B as a Foundation for Analysing Biocontrol Mechanisms

Lukas Nägeli, Martin Schüler, Tina Segessemann, Daniel Frei et autres

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Sequencing data

Maria Paula Rueda‐Mejia, Lukas Nägeli, Stefanie Lutz, Raúl A. Ortiz‐Merino et autres

Illumina MiSeq, ONT, and PacBio raw data used for the genome assembly of C. sargentensis (strain SHA 17.2), which is deposited at NCBI’s Genbank under the BioProject PRJNA763105 and the accession numbers CP083464-CP083471.

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Cyberlindnera sargentensis (SHA 17.2) genome annotation

Florian M. Freimoser, Maria Paula Rueda‐Mejia, Lukas Nägeli, Stefanie Lutz et autres

Annotation for the assembled genome of C. sargentensis (strain SHA 17.2), which is deposited at NCBI’s Genbank under the BioProject PRJNA763105 and the accession numbers CP083464-CP083471.

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Genome sequence data of the antagonistic soil-borne yeast Cyberlindnera sargentensis (SHA 17.2)

Maria Paula Rueda-Mejia, Lukas Nägeli, Stefanie Lutz, Raúl A. Ortiz‐Merino et autres

Cyberlindnera sargentensis strain SHA 17.2, isolated from a Swiss soil sample, exhibited strong antagonistic activity against several plant pathogenic fungi in vitro and was highly competitive against other yeasts in soil. As a basis for identifying the mechanisms underlying its strong antagonistic …

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Genome, transcriptome and secretome analyses of the antagonistic, yeast-like fungus Aureobasidium pullulans to identify potential biocontrol genes

Maria Paula Rueda‐Mejia, Lukas Nägeli, Stefanie Lutz, Richard D. Hayes et autres

Aureobasidium pullulans is an extremotolerant, cosmopolitan yeast-like fungus that successfully colonises vastly different ecological niches. The species is widely used in biotechnology and successfully applied as a commercial biocontrol agent against postharvest diseases and fireblight. However, the exact mechanisms that are responsible …

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Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function

Daniel Gerber, Monica Ghidinelli, Elisa Tinelli, Christian Somandin et autres

Myelination requires extensive plasma membrane rearrangements, implying that molecules controlling membrane dynamics play prominent roles. The large GTPase dynamin 2 (DNM2) is a well-known regulator of membrane remodeling, membrane fission, and vesicular trafficking. Here, we genetically ablated Dnm2 in Schwann cells (SCs) …

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Author response: Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function

Daniel Gerber, Monica Ghidinelli, Elisa Tinelli, Christian Somandin et autres

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