John S. Kizer

Evaluating the Test-Negative Design for COVID-19 Vaccine Effectiveness Using Randomized Trial Data

Leah I. B. Andrews, M. Elizabeth Halloran, Lars van der Laan, Yunda Huang et autres

Importance: The test-negative design (TND) has been widely used to assess postmarketing COVID-19 vaccine effectiveness but requires further evaluation for this application. Objective: To determine whether the TND reliably evaluates vaccine effectiveness against symptomatic COVID-19 using placebo-controlled vaccine efficacy randomized clinical trials …

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Endocrine-Induced Alterations of Monoamine Metabolism in Brain

John S. Kizer

Neonatal Monosodium Glutamate

Richard J. Bodnar, Gary Abrams, Earl A. Zimmerman, Dorothy T. Krieger et autres

Neonatal administration of monosodium glutamate (MSG) produces neurotoxic degeneration of the retina and medial-basal hypothalamus, including the arcuate nucleus. Since this hypothalamic area contains the only neuronal cell bodies in brain which contain adrenocorticotrophic hormone (ACTH) and beta-lipotropin (beta-LPH) and beta-endorphin, destruction …

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Effect of Chronic Treatment with Thyrotropin-Releasing Hormone (TRH) or an Analog of TRH (Linear β-Alanine TRH) on the Hypothalamic-Pituitary-Thyroid Axis

Charles B. Nemeroff, Garth Bissette, Joseph B. Martin, Paul Brazeau et autres

The effects of treatment for 5 or 9 days with varying doses of thyrotropin-releasing hormone (TRH) or the linear beta-alanine TRH congener (pGlu-His-Pro-beta-Ala-NH2) on serum levels of TSH, T3, and T4 were studied in mice and rats. At low doses in rats …

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Contents, Vol. 22, 1976

Yvette Tache, Pierre Du Ruisseau, Jean Taché, H Selye et autres

Author Index Vol. 22, 1976

Yvette Tache, Pierre Du Ruisseau, Jean Taché, H Selye et autres

Dobutamine stress echocardiography was effective for identifying patients at low risk for cardiac events after noncardiac surgery

John S. Kizer

Source Citation Poldermans D, Fioretti PM, Forster T, et al. Dobutamine stress echocardiography for assessment of perioperative cardiac risk in patients undergoing major vascular surgery. Circulation. 1993 May;87:1506-12.

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Postoperative ischemia was associated with cardiac events

John S. Kizer

EtiologySeptember 1, 1993Postoperative ischemia was associated with cardiac eventsJohn S. Kizer, MDJohn S. Kizer, MDUniversity of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA (J.S.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-1993-119-2-056 SectionsAboutFull Text ToolsAdd to favoritesDownload …

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Making sense from antisense: A review of experimental data and developing ideas on sense–antisense peptide recognition

Alexander Tropsha, John S. Kizer, IRWIN M. CHAIKEN

Peptides encoded in the antisense strand of DNA have been predicted and found experimentally to bind to sense peptides and proteins with significant selectivity and affinity. Such sense--antisense peptide recognition has been observed in many systems, most often by detecting binding between …

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Do interhelical side chain-backbone hydrogen bonds participate in formation of leucine zipper coiled coils?

Alexander Tropsha, Jonathan P. Bowen, Frank K. Brown, John S. Kizer

The leucine zipper proteins are a group of transcriptional regulators that dimerize to form a DNA binding domain. It has been proposed that this dimerization results from the hydrophobic association of the alpha-helices of two leucine zipper monomers into a coiled coil. …

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A motif found in propeptides and prohormones that may target them to secretory vesicles

John S. Kizer, Alexander Tropsha

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Alterations in regional brain concentrations of neurotensin and bombesin in Parkinson's disease

Garth Bissette, Charles B. Nemeroff, Michael W. Decker, John S. Kizer et autres

Frozen samples of postmortem human brain tissue from patients with Parkinson's disease (n = 25) and control patients who died without neurological disease (n = 25) were assayed for neurotensin and bombesin by specific radioimmunoassay. Twelve brain regions were examined: substantia nigra, …

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