Markus Decker

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

Hua Gao, Goutam Chakraborty, Ai Ping Lee-Lim, Qianxing Mo et autres

Targeting the Homologous Recombination Pathway in Cancer With a Novel Class of RAD51 Inhibitors

Peng Gu, Liting Xue, Chunyan Zhao, Wenjing Li et autres

Targeting DNA damage response (DDR) pathway has been proposed as an approach for amplifying tumor-specific replicative lesions. RAD51 plays a central role in the DDR process, and thus represents a promising anti-tumor target. We here report the discovery of a series of …

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Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation

Sam C. Nalle, Rosa Barreira da Silva, Hua Zhang, Markus Decker et autres

Antigen cross presentation, whereby exogenous antigens are presented by MHC class I molecules to CD8+ T cells, is essential for generating adaptive immunity to pathogens and tumor cells. Following endocytosis, it is widely understood that protein antigens must be transferred from endosomes …

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Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation

Sam C. Nalle, Rosa Barreira da Silva, Hua Zhang, Markus Decker et autres

ABSTRACT Antigen cross presentation, whereby exogenous antigens are presented by MHC class I molecules to CD8+ T cells, is essential for generating adaptive immunity to pathogens and tumor cells ( 1 ). Following endocytosis, it is widely understood that protein antigens must …

us, nl, au (code pays fourni par la source)

Chance für einen Neubeginn?

Markus Decker

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Chance für einen Neubeginn?

Markus Decker

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Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication

Nina Peel, Jyoti Iyer, Anar Naik, Michael Dougherty et autres

In humans perturbations of centriole number are associated with tumorigenesis and microcephaly, therefore appropriate regulation of centriole duplication is critical. The C. elegans homolog of Plk4, ZYG-1, is required for centriole duplication, but our understanding of how ZYG-1 levels are regulated remains …

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Protein phosphatase 1 down regulates ZYG-1 levels to limit centriole duplication

Nina Peel, Jyoti Iyer, Anar Naik, Michael Dougherty et autres

Abstract In humans perturbations of centriole number are associated with tumorigenesis and microcephaly, therefore appropriate regulation of centriole duplication is critical. The C. elegans homolog of Plk4, ZYG-1, is required for centriole duplication, but our understanding of how ZYG-1 levels are regulated …

us (code pays fourni par la source)

Centrosomes are autocatalytic droplets of pericentriolar material organized by centrioles

David Zwicker, Markus Decker, Steffen Jaensch, Anthony A. Hyman et autres

Centrosomes are highly dynamic, spherical organelles without a membrane. Their physical nature and their assembly are not understood. Using the concept of phase separation, we propose a theoretical description of centrosomes as liquid droplets. In our model, centrosome material occurs in a …

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Centrosomes are autocatalytic droplets of pericentriolar material organized by centrioles

David Zwicker, Markus Decker, Steffen Jaensch, Anthony A. Hyman et autres

Centrosomes are highly dynamic, spherical organelles without a membrane. Their physical nature and their assembly are not understood. Using the concept of phase separation, we propose a theoretical description of centrosomes as liquid droplets. In our model, centrosome material occurs in a …

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

Hua Gao, Goutam Chakraborty, Ai Ping Lee-Lim, Qianxing Mo et autres

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

Hua Gao, Goutam Chakraborty, Ai Ping Lee-Lim, Qianxing Mo et autres

us (code pays fourni par la source)