Calvin V. Lieu

The plant hormone, 6-benzylaminopurine, ameliorates obesity in male and female mice while on a high-fat diet

Calvin V. Lieu, Cindy Zhang, Neruja Loganathan, Leon French et autres

Obesity is a global health crisis. Currently available treatments, while effective, show several undesirable side effects that hinder their long-term use. Herein, we investigated the anti-obesity potential of 6-benzylaminopurine (BAP), a plant hormone commonly used in agricultural settings to enhance plant development, …

ca, us (code pays fourni par la source)

Food and the brain: Neural and endocrine control of feeding, metabolism, and reproduction

Naira da Silva Mansano, Calvin V. Lieu, Alfonso Abizaid

Feeding and reproductive function are regulated by intricate systems that monitor food availability and energy stores, and on the basis of energy status, promote or put a brake on reproduction. This is particularly evident in the systems that regulate feeding and reproductive …

us, ca (code pays fourni par la source)

OR01-01 Novel Anti-obesity Phytohormone Promotes Cellular Insulin Sensitivity in Hypothalamic Neurons

Cindy Zhang, Calvin V. Lieu, Wenyuan He, Denise D. Belsham

Abstract C.X. Zhang: None. C. Lieu: None. W. He: None. D.D. Belsham: None. Obesity is a global epidemic and is associated with dangerous comorbidities, such as type 2 diabetes mellitus (T2DM). Insulin is sensed by insulin receptor (INSR)-expressing neurons in the hypothalamus, …

ca (code pays fourni par la source)

Immortalization and Characterization of GFAP-expressing Glial Cells from the Adult Mouse Hypothalamus, Cortex, and Brain Stem

Neruja Loganathan, Calvin V. Lieu, Denise D. Belsham

The generation of astrocyte cell lines from the hypothalamus is key to study glial involvement in hypothalamic physiology, including energy homeostasis. As such, we immortalized astrocytes from the hypothalamus of an adult male CD-1 mouse using SV40 T-antigen to generate the mHypoA-Ast1 …

ca (code pays fourni par la source)

Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus

Calvin V. Lieu, Neruja Loganathan, Denise D. Belsham

The hypothalamus maintains whole-body homeostasis by integrating information from circulating hormones, nutrients and signaling molecules. Distinct neuronal subpopulations that express and secrete unique neuropeptides execute the individual functions of the hypothalamus, including, but not limited to, the regulation of energy homeostasis, reproduction …

ca (code pays fourni par la source)

Bisphenol A induces miR-708-5p through an ER stress-mediated mechanism altering neuronatin and neuropeptide Y expression in hypothalamic neuronal models

Emma K. McIlwraith, Calvin V. Lieu, Denise D. Belsham

ca (code pays fourni par la source)